Faculty profile

Robert Rottapel

ResearcherMedical BiophysicsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Robert Rottapel

Researcher

Medical Biophysics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
20 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2024.
Supervised 3 trainees who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

121

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Signal Transduction Bone Kinase Activation Noncoding Rna Nonsense Mediated Decay Ovarian Cancer Rheumatoid Arthritis Autoantibodies

Latest papers

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.
Journal of medicinal chemistry · 2026
Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis.
Immunology · 2026
Preclinical Combination Targeting VEGF and PI3K in a Rare, Aggressive Mixed Endometrial Carcinoma: An Applied Case Report.
Cancer research communications · 2026

All 78 publications

Latest funding

Nonsense Mediated RNA Decay Shapes the Expressed Transcriptome Required for Ovarian Cancer Progression
CIHR · 2024 · Nominated PI
$956,250
Defining the role of GCN2 as an adaptive stress response kinase in ovarian cancer
CIHR · 2022 · Supervisor
$135,000
Tankyrase represses macrophage derived inflammatory cytokines and controls osteoclast activity during bone development.
CIHR · 2022 · Nominated PI
$956,250

All 12 grants and awards

78 publications.

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Yin J, Srivastava S, Tang X, Galbraith C, Uchenunu O, Miller J, Liu Y, Crescenzi I, Kiyota T, Kurinov I, Costa-Mattioli M, Laufer R, Aman A, Rottapel R, Ramnauth J, Haakonsen DL, Uehling DE, Sicheri F

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c03664 PMID: 42324916

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis.

Zhao T, Carleton GA, Preshaw S, MacPherson S, Shiyuk M, Monaghan J, Han J, Uchenunu O, Rottapel R, DeBerardinis RJ, Stewart KM, Kim BH, Ausió J, Goodlett DR, Pětrošová H, Duncan KD, Lum JJ

Immunology2026

DOI: 10.1111/imm.70177 PMID: 42503479

Preclinical Combination Targeting VEGF and PI3K in a Rare, Aggressive Mixed Endometrial Carcinoma: An Applied Case Report.

Radulovich N, Pina PS, Udaskin ML, Li Q, Nixon KCJ, Xie IY, Nand A, Rosen JC, Li M, Hodgson A, Pham NA, Oza AM, Lupien M, Rottapel R, Tsao MS, Lheureux S

Cancer research communications2026

DOI: 10.1158/2767-9764.crc-25-0634 PMID: 41886729

Rethinking ovarian cancer III: the past decade and future directions.

Balkwill FR, Laumont CM, Burdett N, Le Saux O, Garsed DW, Grither WR, Nijhuis AM, Recouvreux MS, Kang Z, Zhang R, Chiappinelli KB, Lee JS, Laniti DD, McNeish I, Ahmed AA, Rottapel R, Conejo-Garcia JR, Odunsi K, Pharoah PDP, Zamarin D, Ishak CA, Fotopoulou C, Buckanovich RJ, Labidi-Galy I, Brenton JD, Lengyel E, Cook DP, George SHL, Lheureux S, Drapkin R, Nephew KP, Adams S, Pathania S, Nelson BH, Färkkilä A, Fuh K, Neel BG, Bowtell DD

Nature reviews. Cancer2026

DOI: 10.1038/s41568-026-00916-0 PMID: 41975230

Methionine regulates antitumor function of CD8+ T cells through polyamine synthesis.

Zhao T, Carleton GA, Macpherson S, Shiyuk M, Monaghan J, Han J, Uchenunu O, Rottapel R, DeBerardinis RJ, Stewart KM, Kim BH, Ausió J, Goodlett DR, Pětrošová H, Duncan KD, Lum JJ

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.10.03.680201 PMID: 41256484

Phosphorylation as a candidate regulatory mechanism for effector recruitment to tankyrase.

Broadway BJ, Pollock K, Cronin N, Rottapel R, Sicheri F, Guettler S

Royal Society open science2025

DOI: 10.1098/rsos.250824 PMID: 41103766

The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.

Sahasrabuddhe AA, Chen X, Ma K, Wu R, Liang HC, Kapoor R, Chhipa RR, Onder O, McFetridge C, Van Arnam JS, Zhang X, Morrissette JJD, Pillai V, Li MM, Szankasi P, Basrur V, Conlon KP, Raabe TD, Bailey NG, Hogaboam CM, Rottapel R, Kim J, López C, Schlesner M, Siebert R, Dreval K, Morin RD, Moro L, Pagano M, Staudt LM, Lim MS, Elenitoba-Johnson KSJ

Cancer discovery2025

DOI: 10.1158/2159-8290.cd-24-0442 PMID: 39820335

Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.

Ishak CA, Marhon SA, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga IM, Peralta M, Lungu IM, Gomez S, Liang SB, Shen SY, Chen R, Chen J, Chatterjee B, Wanniarachchi KN, Lee J, Zehrbach N, Hosseini A, Mehdipour P, Sun S, Solovyov A, Ettayebi I, Francis KE, He A, Wu T, Feng S, da Silva Medina T, Campos de Almeida F, Bayani J, Li J, MacDonald S, Wang Y, Garcia SS, Arthofer E, Diab N, Srivastava A, Austin PT, Sabatini PJB, Greenbaum BD, O'Brien CA, Shepherd TG, Tsao MS, Chiappinelli KB, Oza AM, Clarke BA, Rottapel R, Lheureux S, De Carvalho DD

Cancer discovery2025

DOI: 10.1158/2159-8290.cd-24-0094 PMID: 39776167

Author Correction: Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP-ribose) polymerase inhibitor resistance in high-grade serous ovarian cancer.

Sauriol SA, Carmona E, Udaskin ML, Radulovich N, Leclerc-Desaulniers K, Rottapel R, Oza AM, Lheureux S, Provencher DM, Mes-Masson AM

Scientific reports2024

DOI: 10.1038/s41598-024-60769-1 PMID: 38693303

Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.

Srivastava T, Garola RE, Zhou J, Boinpelly VC, Rezaiekhaligh MH, Joshi T, Jiang Y, Ebadi D, Sharma S, Sethna C, Staggs VS, Sharma R, Gipson DS, Hao W, Wang Y, Mariani LH, Hodgin JB, Rottapel R, Yoshitaka T, Ueki Y, Sharma M

JCI insight2024

DOI: 10.1172/jci.insight.170055 PMID: 38127456

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Robert Rottapel

Research

Latest papers

Latest funding

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis.

Preclinical Combination Targeting VEGF and PI3K in a Rare, Aggressive Mixed Endometrial Carcinoma: An Applied Case Report.

Rethinking ovarian cancer III: the past decade and future directions.

Methionine regulates antitumor function of CD8+ T cells through polyamine synthesis.

Phosphorylation as a candidate regulatory mechanism for effector recruitment to tankyrase.

The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis.

Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.

Author Correction: Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP-ribose) polymerase inhibitor resistance in high-grade serous ovarian cancer.

Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.

Frequent collaborators

Mitsuhiko Ikura

Stephanie Lheureux

Jason Moffat

Brian Raught

Anne-Marie Mes-Masson

Anne-Claude Gingras

Ming-Sound Tsao

Frank Sicheri

Sabrina Hoa

Nancy Maltez

Ahmed Aman

Laurie Ailles

Vuk Stambolic

Mathieu Lemaire

Marie Hudson

Marianne Koritzinsky

Sabrina Hoa

Janet Pope

Carrie Ye

Michael Surette

Michael Glogauer

Wei Xu

Andrew Wilde

Bryan Coburn

Marc Grynpas

Laurence Pelletier

Jennifer Gommerman

Jayne Danska