Faculty profile
Nigil Haroon
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Research
Latest papers
Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy.
ACR open rheumatology · 2026
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis & rheumatology (Hoboken, N.J.) · 2026 · senior author
FOXO3a Polymorphisms Are Not Associated With Axial Spondyloarthritis or Psoriatic Arthritis Susceptibility in a Canadian Cohort, With Ancestry-Specific Findings.
International journal of rheumatic diseases · 2026
Latest funding
- $302,174
TRABID and anti-inflammatory checkpoint factors in SpA
CIHR · 2025 · Nominated PI
- $344,250
Sec16A-Mediated Autophagy and HLA-B27 Trafficking: Mechanistic Insights Into Antigen Presentation in Axial Spondyloarthritis
CIHR · 2025 · Nominated PI
- $120,000
The Role of the Immunometabolism in Spondyloarthritis Drug Response Outcomes
CIHR · 2025 · Supervisor
112 publications.
Reduction of CXCR3+CCR6+ CD4+ T Cells and IL-17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy.
Pacheco A, Remalante-Rayco P, Haroon N, Poddubnyy D, Inman RD
T cells, the Next Big Target in Axial Spondyloarthritis?
Aparnathi MK, Haroon N
FOXO3a Polymorphisms Are Not Associated With Axial Spondyloarthritis or Psoriatic Arthritis Susceptibility in a Canadian Cohort, With Ancestry-Specific Findings.
Pacheco A, Rahman P, Chandran V, Haroon N, Inman RD
Certolizumab Pegol Reduced Anterior Uveitis Flares Compared With Standard Non-Biologic Treatment: Results From an Overlap Weighting Analysis in High-Risk Patients With Axial Spondyloarthritis.
Haroon N, Baskurt Z, Chim T, Inman RD, Kumke T, Tham R, Kim M, van der Horst-Bruinsma I, Gensler LS
Determinants of Difficult-to-Manage and Treatment-Refractory Axial Spondyloarthritis: A Cross-Sectional Analysis Within a Longitudinal Cohort.
Remalante-Rayco P, Passalent L, Chim T, Vijayan H, Alnasser M, Baskurt Z, Inman RD, Haroon N, Poddubnyy D
Segmental spinal damage predicts mobility restriction and functional decline in radiographic axial spondyloarthritis: a longitudinal study.
Sari I, Lee S, Johnson SR, Inman RD, Haroon N
Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada Living Treatment Recommendations for the Management of Axial Spondyloarthritis: Update #1
Richard N, Pardo JP, Mirza R, Aydin SZ, Bessette L, Mosher D, Boyd T, Chan J, Eder L, Passalent L
Impact of disease manifestations on first biologic drug survival in axial spondyloarthritis: a real-life Canadian study.
Hurtubise R, Rohekar S, Haroon N, Baskurt Z, Chim T, Zummer M, Inman RD, Richard N, SpondyloArthritis Research Consortium of Canada (SPARCC)
Inflammatory bowel disease does not confer higher disease activity or greater radiographic progression in axial spondyloarthritis.
Remalante-Rayco P, Daghistani Y, Chim T, Baskurt Z, Keshavarzi S, Passalent L, Poddubnyy D, Inman RD, Haroon N
Impact of clinical subtype and sex on first-line biologic therapy discontinuation in axial spondyloarthritis.
Remalante-Rayco P, Baja ES, Baskurt Z, Chim T, Panelo CIA, Osio-Salido E, Inman RD, Dans LF, Haroon N
TRABID and anti-inflammatory checkpoint factors in SpA
Principal investigators: Haroon, Nigil
Keywords: Arthritis; Deubiquitinase; Trabid
Sec16A-Mediated Autophagy and HLA-B27 Trafficking: Mechanistic Insights Into Antigen Presentation in Axial Spondyloarthritis
Principal investigators: Haroon, Nigil
Keywords: Antigen Presentation; Autophagy; Axial Spondyloarthritis; Cellular Trafficking; Hla-B27; Immunity; Inflammation; Sec16a
The Role of the Immunometabolism in Spondyloarthritis Drug Response Outcomes
Principal investigators: Nguyen, Phuong N
Keywords: Ankylosing Spondylitis; Autoimmune Diseases; Immunometabolomics; Machine Learning; Personalized Medicine; Psoriatic Arthritis
Immune response after COVID-19 vaccination during maintenance therapy in immune-mediated inflammatory diseases: an observational cohort study (IMPACT)
Principal investigators: Chandran, Vinod
Keywords: Antibody Response; Covid-19; Immune-Mediated Inflammatory Diseases; Immunosuppression; T Cell Response; Vaccination; Variants Of Concern
HIF1-alpha interacts with MIF to drive inflammation and new bone formation in spondyloarthritis
Principal investigators: Haroon, Nigil
Keywords: Arthritis; Bone; Inflammation; Spondyloarthritis
Therapeutic Targeting of MIF in a Spondyloarthritis Mouse Model
Principal investigators: Haroon, Nigil
Keywords: Arthritis; Inflammation; Spondylitis
Macrophage migration inhibitory factor (MIF) as a Crucial Regulatory Cytokine and Therapeutic Target in Ankylosing Spondylitis
Principal investigators: Nakamura, Akihiro
Keywords: Ankylosing Spondylitis; Inflammation; Low Back Pain; Macrophage Migration Inhibitory Factor; New Bone Formation
Human Immunology Spondyloarthritis Team (HUMISPOT) studying immunopathogenesis, disease heterogeneity and drug discovery in spondyloarthritis
Principal investigators: Haroon, Nigil; Wither, Joan E; Allard-Chamard, Hugues; Chandran, Vinod; Crome, Sarah A; Gladman, Dafna D; Inman, Robert D; Jurisica, Igor; Rahman, Proton
Keywords: Antibody; Immunoassay; Sequencing; Spondyloarthritis; T Cells; T Regulatory Cells
Personalized medicine for ankylosing spondylitis
Principal investigators: Haroon, Nigil
Keywords: Arthritis
Definitive treatment of AS by blocking Macrophage Migration Inhibitory Factor (MIF)
Principal investigators: Haroon, Nigil
Keywords: Ankylosis; Bone Homeostasis; Inflammation; Spondyloarthritis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Immunology and Rheumatology
- Rheumatology
- Genetics
- Institute of Health Policy, Management, and Evaluation
- Statistics and Actuarial Science
- Orthopedics
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Vinod Chandran
Rheumatology
8 shared papers, latest 2026
Proton Rahman
Genetics
7 shared papers, latest 2024
Dianne Mosher
Medicine
4 shared papers, latest 2026
Proton Rahman
Immunology and Rheumatology
4 shared papers, latest 2015
Richard Cook
Statistics and Actuarial Science
4 shared papers, latest 2023
Jessica Widdifield
Institute of Health Policy, Management, and Evaluation
4 shared papers, latest 2023
Lihi Eder
Faculty
4 shared papers, latest 2026
Robert Inman
Medicine
4 shared papers, latest 2026
Zahi Touma
Medicine
3 shared papers, latest 2023
Mohit Kapoor
Orthopedics
3 shared papers, latest 2024
Igor Jurisica
Rheumatology
3 shared papers, latest 2024
Sareh Keshavarzi
Biostatistics Division
2 shared papers, latest 2025
Carter Thorne
Faculty
2 shared papers, latest 2015
Arielle Mendel
Faculty
2 shared papers, latest 2023
Arielle Mendel
Faculty
2 shared papers, latest 2023
Rahim Moineddin
Department of Family and Community Medicine
2 shared papers, latest 2023
Sasha Bernatsky
Faculty
2 shared papers, latest 2023
Sasha Bernatsky
Medicine
2 shared papers, latest 2023
Simone Vigod
Family Practice
2 shared papers, latest 2020
Reza Donald Mirza
Medicine
2 shared papers, latest 2026
Yasir Mohamud
Faculty
1 shared papers, latest 2021
Thomas Pulinilkunnil
Biochemistry and Molecular Biology
1 shared papers, latest 2021
Ina Dobrinski
Faculty
1 shared papers, latest 2021
Rajiv Gandhi
Orthopedics
1 shared papers, latest 2019
Vincent Piguet
Faculty
1 shared papers, latest 2023
Steve Jean
Anatomie et biologie cellulaire
1 shared papers, latest 2021
Khosrow Adeli
Department of Laboratory Medicine and Pathobiology
1 shared papers, latest 2021
Sophie Roux
Rhumatologie
1 shared papers, latest 2021
Honglin Luo
Pathology and Laboratory Medicine
1 shared papers, latest 2021
Sandra Turcotte
Chemistry and Biochemistry
1 shared papers, latest 2021
Claire Bombardier
Toronto General Research Institute
1 shared papers, latest 2022
Gary Sweeney
Biology
1 shared papers, latest 2021
Elie Akl
Health Research Methods, Evidence, and Impact
1 shared papers, latest 2016
Isabella Caniggia
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2021
J Michael Paterson
Family Medicine
1 shared papers, latest 2014
Michael Sacher
Biology
1 shared papers, latest 2021
Martin Post
Pediatrics and Physiology
1 shared papers, latest 2021
Sabah Hussain
Medicine
1 shared papers, latest 2021
Anne-Claude Gingras
Department of Molecular Genetics
1 shared papers, latest 2023
Caigan Du
Urologic Sciences
1 shared papers, latest 2021
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