Faculty profile

Thomas Pulinilkunnil

ResearcherBiochemistry and Molecular BiologyDalhousie University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Dalhousie University directory, so their courses may be missing. Find their university profile.

Thomas Pulinilkunnil

Researcher

Biochemistry and Molecular Biology

Health Sciences

Dalhousie University

Halifax, Nova Scotia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 3 research grants (2 NSERC, 1 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Cardiomyocyte Cardiomyopathy Cell Death Energy Metabolism Heart Disease Lipid Toxicity Lysosomal Autophagy Mitochondria

Latest papers

TRPML1 loss disrupts lysosome-mitochondria homeostasis and sensitizes MDA-MB-231 triple-negative breast cancer cells to chemotherapy.
The Journal of biological chemistry · 2026
Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
Circulation. Heart failure · 2025
Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.
Biochimica et biophysica acta. Molecular cell research · 2025

All 41 publications

Latest funding

Role of TFEB in cardiometabolic homeostasis
CIHR · 2024 · Nominated PI
$918,000
Sexual dimorphism in right (-sided) heart failure: Role of sphingosine kinsae-1 and progesterone in right ventricular angiogenesis and remodelling
CIHR · 2023 · Co-investigator
$745,876
Sexual dimorphism in right (-sided) heart failure: Role of progesterone in right ventricular angiogenesis and remodelling
CIHR · 2022 · Co-investigator
$100,000

All 6 grants and awards

41 publications.

TRPML1 loss disrupts lysosome-mitochondria homeostasis and sensitizes MDA-MB-231 triple-negative breast cancer cells to chemotherapy.

Syeda AK, Almasi S, Benson CJ, Kennedy BE, Yoast RM, Emrich SM, Delima-Baril A, Slade L, Pakkiriswami S, Vijayan VV, Sheela UB, Gujar S, Pulinilkunnil T, Trebak M, El Hiani Y

The Journal of biological chemistry2026

DOI: 10.1016/j.jbc.2026.113596 PMID: 42772563

Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.

Karwi QG, Zhang L, Gopal K, Wagg CS, Ho KL, Sun Q, Panidarapu S, Persad K, Altuany B, Damen S, Ketema E, Levasseur J, Pulinilkunnil T, Ussher JR, Dyck JRB, Lopaschuk GD

Circulation. Heart failure2025

DOI: 10.1161/circheartfailure.124.012012 PMID: 40709461

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Gomes GMA, Xu M, Syeda AKR, Raudonis R, Almasi S, Vijayan VV, Gujar S, Dong X, Cheng Z, Pulinilkunnil T, El Hiani Y

Biochimica et biophysica acta. Molecular cell research2025

DOI: 10.1016/j.bbamcr.2025.119979 PMID: 40348344

Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Jose A, Pakkiriswami S, Mercer A, Paudel Y, Yi E, Fernando J, Pulinilkunnil T, Kienesberger PC

American journal of physiology. Heart and circulatory physiology2025

DOI: 10.1152/ajpheart.00518.2024 PMID: 39805037

Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes.

Nelson VL, Eadie AL, Perez L, Madhu M, Platt M, Mercer A, Pulinilkunnil T, Kienesberger P, Simpson JA, Brunt KR

Biomolecules2024

DOI: 10.3390/biom14101299 PMID: 39456232

Effect of (poly)phenol-rich 'Daux Belan' apple supplementation on diet-induced obesity and glucose intolerance in C57BL/6NCrl mice.

Yu CHJ, Kienesberger PC, Pulinilkunnil T, Rupasinghe HPV

Scientific reports2023

DOI: 10.1038/s41598-023-43687-6 PMID: 37821510

Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells.

Slade L, Biswas D, Kienesberger PC, Pulinilkunnil T

The Journal of biological chemistry2022Senior author

DOI: 10.1016/j.jbc.2022.102692 PMID: 36372230

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.

Uddin GM, Karwi QG, Pherwani S, Gopal K, Wagg CS, Biswas D, Atnasious M, Wu Y, Wu G, Zhang L, Ho KL, Pulinilkunnil T, Ussher JR, Lopaschuk GD

Metabolism: clinical and experimental2021

DOI: 10.1016/j.metabol.2021.154871 PMID: 34478752

Nanoparticle surface-enhanced Raman spectroscopy as a noninvasive, label-free tool to monitor hematological malignancy.

Grieve S, Puvvada N, Phinyomark A, Russell K, Murugesan A, Zed E, Hassan A, Legare JF, Kienesberger PC, Pulinilkunnil T, Reiman T, Scheme E, Brunt KR

Nanomedicine (London, England)2021

DOI: 10.2217/nnm-2021-0076 PMID: 34547916

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Biswas D, Slade L, Duffley L, Mueller N, Dao KT, Mercer A, Pakkiriswami S, El Hiani Y, Kienesberger PC, Pulinilkunnil T

Cell death discovery2021Senior author

DOI: 10.1038/s41420-021-00602-0 PMID: 34526485

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Thomas Pulinilkunnil

Research

Latest papers

Latest funding

TRPML1 loss disrupts lysosome-mitochondria homeostasis and sensitizes MDA-MB-231 triple-negative breast cancer cells to chemotherapy.

Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.

Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer.

Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes.

Effect of (poly)phenol-rich 'Daux Belan' apple supplementation on diet-induced obesity and glucose intolerance in C57BL/6NCrl mice.

Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells.

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart.

Nanoparticle surface-enhanced Raman spectroscopy as a noninvasive, label-free tool to monitor hematological malignancy.

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.

Role of TFEB in cardiometabolic homeostasis

Sexual dimorphism in right (-sided) heart failure: Role of sphingosine kinsae-1 and progesterone in right ventricular angiogenesis and remodelling

Sexual dimorphism in right (-sided) heart failure: Role of progesterone in right ventricular angiogenesis and remodelling

Identifying and characterizing pathways of amino acid signaling and metabolism

A multimodal small animal imaging system

Identifying and characterizing pathways of amino acid metabolism and signaling

Frequent collaborators

Petra Kienesberger

Brian Rodrigues

Shashi Gujar

Jean-François Legare

Corey Nislow

Jean Marshall

Ina Dobrinski

Gary Sweeney

Isabella Caniggia

Nigil Haroon

Steve Jean

Khosrow Adeli

Sophie Roux

Jean-Jacques Lebrun

Tony Reiman

Xianping Dong

Marc Surette

Xi-Long Zheng

Zhenyu Cheng

Tony Reiman

Michael Sacher