Faculty profile

Michael Sacher

ResearcherBiologyConcordia University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Concordia University directory, so their courses may be missing. Find their university profile.

Michael Sacher

Researcher

Biology

Health Sciences

Concordia University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (7 NSERC, 2 CIHR), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2009.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

5,052

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Endoplasmic Reticulum Golgi Membrane Traffic Trapp Autophagy Cell-Free Assay Guanine Nucleotide Exchange Factor Muscular Dystrophy

Latest papers

Edward Sacher (1934-2023): Understanding Chemistry at the Interface.
Molecules (Basel, Switzerland) · 2026 · first author
Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.
Cells · 2026 · senior author
Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking.
eLife · 2026

All 44 publications

Latest funding

Replacement of a non-functional liquid chromatography system in the Biology Department at Concordia University
NSERC · 2024 · Principal investigator
$119,859
How mitochondrial physiology impacts protein sorting
NSERC · 2020 · Principal investigator
$252,000
The functions of mammalian TRAPP complexes and their role in disease
CIHR · 2018 · Nominated PI
$765,000

All 14 grants and awards

44 publications.

Edward Sacher (1934-2023): Understanding Chemistry at the Interface.

Sacher M

Molecules (Basel, Switzerland)2026First author

DOI: 10.3390/molecules31173088 PMID: 42738747

Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.

Abboud C, Shokohi R, Pape O, Mehranfar M, Baple EL, Damseh N, Sacher M

Cells2026Senior author

DOI: 10.3390/cells15171555 PMID: 42738849

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking.

Sandkuhler SE, Youngs KS, Gottipalli O, Owlett LD, Bandora MB, Naaz A, Kim E, Wang L, Wojtovich A, Gupta V, Sacher M, Mackenzie SJ

eLife2026

DOI: 10.7554/elife.105418 PMID: 41504601

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis.

Bögershausen N, Cavdarli B, Nagai TH, Milev MP, Wolff A, Mehranfar M, Schmidt J, Choudhary D, Gutiérrez-Gutiérrez Ó, Cyganek L, Saint-Dic D, Zibat A, Köhrer K, Wollenweber TE, Wieczorek D, Altmüller J, Borodina T, Kaçar D, Haliloğlu G, Li Y, Thiel C, Sacher M, Knapik EW, Yigit G, Wollnik B

JCI insight2025

DOI: 10.1172/jci.insight.173484 PMID: 40131364

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance.

Muffels IJJ, Waterham HR, D'Alessandro G, Zagnoli-Vieira G, Sacher M, Lefeber DJ, Van der Vinne C, Roifman CM, Gassen KLI, Rehmann H, Van Haaften-Visser DY, Nieuwenhuis ESS, Jackson SP, Fuchs SA, Wijk F, van Hasselt P

Genome medicine2025

DOI: 10.1186/s13073-025-01433-9 PMID: 39920830

Heme's relevance genuine? Re-visiting the roles of TANGO2 homologs including HRG-9 and HRG-10 in C. elegans.

Sandkuhler SE, Youngs KS, Owlett L, Bandora MB, Naaz A, Kim ES, Wang L, Wojtovich AP, Gupta VA, Sacher M, Mackenzie SJ

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2023.11.29.569072 PMID: 38106020

A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome.

Zykaj E, Abboud C, Asadi P, Warsame S, Almousa H, Milev MP, Greco BM, López-Sánchez M, Bratkovic D, Kachroo AH, Pérez-Jurado LA, Sacher M

Cells2024Senior author

DOI: 10.3390/cells13171457 PMID: 39273027

Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease.

Mehranfar M, Asadi P, Shokohi R, Milev MP, Gamberi C, Sacher M

Biochemical and biophysical research communications2024Senior author

DOI: 10.1016/j.bbrc.2024.150047 PMID: 38718569

TANGO2 deficiency disease is predominantly caused by a lipid imbalance.

Sacher M, DeLoriea J, Mehranfar M, Casey C, Naaz A, Gamberi C

Disease models & mechanisms2024First author

DOI: 10.1242/dmm.050662 PMID: 38836374

TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions.

Almousa H, Lewis SA, Bakhtiari S, Nordlie SH, Pagnozzi A, Magee H, Efthymiou S, Heim JA, Cornejo P, Zaki MS, Anwar N, Maqbool S, Rahman F, Neilson DE, Vemuri A, Jin SC, Yang XR, Heidari A, van Gassen K, Trimouille A, Thauvin-Robinet C, Liu J, Bruel AL, Tomoum H, Shata MO, Hashem MO, Toosi MB, Karimiani EG, Yeşil G, Lingappa L, Baruah D, Ebrahimzadeh F, Van-Gils J, Faivre L, Zamani M, Galehdari H, Sadeghian S, Shariati G, Mohammad R, van der Smagt J, Qari A, Vincent JB, Innes AM, Dursun A, Özgül RK, Akar HT, Bilguvar K, Mignot C, Keren B, Raveli C, Burglen L, Afenjar A, Kaat LD, van Slegtenhorst M, Alkuraya F, Houlden H, Padilla-Lopez S, Maroofian R, Sacher M, Kruer MC

Brain : a journal of neurology2024

DOI: 10.1093/brain/awad301 PMID: 37713627

Replacement of a non-functional liquid chromatography system in the Biology Department at Concordia University

Principal investigatorNSERC2024Research Tools and Instruments

Principal investigators: Sacher, Michael

Keywords: ion exchange; liquid chromatography; protein interactions; protein purification; size exclusion

$119,859

How mitochondrial physiology impacts protein sorting

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Sacher, Michael

$252,000

The functions of mammalian TRAPP complexes and their role in disease

Nominated PICIHR2018Project Grant

Principal investigators: Sacher, Michael G

Keywords: Autophagy; Cell-Free Assay; Endoplasmic Reticulum; Golgi; Guanine Nucleotide Exchange Factor; Membrane Traffic; Muscular Dystrophy; Rab11 Gtpase; Trapp

$765,000

The functions of the yeast TRAPP complexes and the longin domain-containing protein Tca17 in membrane traffic

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Sacher, Michael

$39,000

An ultracentrifuge and rotors to support multiple NSERC-funded programs

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Zerges, William

$136,736

Laser scanning confocal microscope replacement for Concordia University

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Brett, Christopher

$117,657

Structure and function of the mammalian TRAPP multisubunit tethering complex

Nominated PICIHR2012Operating Grant

Principal investigators: Sacher, Michael G

Keywords: Cell Biology; Electron Microscopy; Endoplasmic Reticulum; Golgi; Membrane Traffic; Sedlin; Sedt; Tethering Factors; Trapp

$694,338

Factors affecting membrane traffic in yeast

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Sacher, Michael

$170,000

Upgrade of the tissue culture facility at Concordia University

Principal investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Sacher, Michael

$44,327

Characterization of the yeast and mammalian Trs23 subunit of the TRAPP vesicle tethering complex

SupervisorCIHR2009Master's Award: Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Brunet, Stephanie

Keywords: Endoplasmic Reticulum; Golgi; Membrane Trafficking; Tethering; Trapp; Trappc4; Trs23p; Vesicle; Yeast; Yeast Genetics; Yeast-Two-Hybrid

$17,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Michael Sacher

Research

Latest papers

Latest funding

Edward Sacher (1934-2023): Understanding Chemistry at the Interface.

Stepwise Humanization of the Yeast TRAPP Core Enables Functional Analysis of TRAPP Variants.

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking.

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis.

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance.

Heme's relevance genuine? Re-visiting the roles of TANGO2 homologs including HRG-9 and HRG-10 in C. elegans.

A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome.

Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease.

TANGO2 deficiency disease is predominantly caused by a lipid imbalance.

TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions.

Replacement of a non-functional liquid chromatography system in the Biology Department at Concordia University

How mitochondrial physiology impacts protein sorting

The functions of mammalian TRAPP complexes and their role in disease

The functions of the yeast TRAPP complexes and the longin domain-containing protein Tca17 in membrane traffic

An ultracentrifuge and rotors to support multiple NSERC-funded programs

Laser scanning confocal microscope replacement for Concordia University

Structure and function of the mammalian TRAPP multisubunit tethering complex

Factors affecting membrane traffic in yeast

Upgrade of the tissue culture facility at Concordia University

Characterization of the yeast and mammalian Trs23 subunit of the TRAPP vesicle tethering complex

Frequent collaborators

Isabella Caniggia

Khosrow Adeli

Honglin Luo

Steve Jean

Xi-Long Zheng

Sandra Turcotte

Eldad Zacksenhaus

Gary Sweeney

Xiaoyan Jiang

Michel Roberge

Nigil Haroon

Dusica Maysinger

Ivan Topisirovic

Martin Gleave

Sophie Roux

Jean-Jacques Lebrun

Arnim Pause

Ivan Topisirovic

Shashi Gujar

Urban Emmenegger

Andre Bedard

John Lee