Faculty profile

Alexandre Orthwein

ResearcherMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Alexandre Orthwein

Researcher

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2024.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (4 CIHR, 1 NSERC), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Crc Antibody Diversification B-Cell Biology Chromosomal Translocation Class Switch Recombination Deubiquitinase Dna Damage/Repair Dna Double-Strand Breaks

Latest papers

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.
Cancer research · 2024
The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.
Blood advances · 2024
The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.
Molecular and cellular biology · 2024 · senior author

All 25 publications

Latest funding

Deciphering the role of the E3 ubiquitin ligase HERC1 in the chemotherapy response of acute myeloid leukemia.
CIHR · 2022 · Co-investigator
$60,000
Canada Reseach Chair - Tier 2
CIHR · 2021 · Nominated PI
$500,000
X-Ray Irradiation Platform for cells and small animal studies
NSERC · 2017 · Principal investigator
$149,671

All 6 grants and awards

25 publications.

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.

Heath J, Mirabelli C, Annis MG, Sabourin V, Hebert S, Findlay S, Kim H, Witcher M, Kleinman CL, Siegel PM, Orthwein A, Ursini-Siegel J

Cancer research2024

DOI: 10.1158/0008-5472.can-23-3887 PMID: 39137399

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

Jankovic M, Poon WWL, Gonzales-Losada C, Vazquez GG, Sharif-Askari B, Ding Y, Craplet-Desombre C, Ilie A, Shi J, Wang Y, Jayavelu AK, Orthwein A, Mercier FÉ

Blood advances2024

DOI: 10.1182/bloodadvances.2023011540 PMID: 39093953

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.

Luo VM, Shen C, Worme S, Bhagrath A, Simo-Cheyou E, Findlay S, Hébert S, Wai Lam Poon W, Aryanpour Z, Zhang T, Zahedi RP, Boulais J, Buchwald ZS, Borchers CH, Côté JF, Kleinman CL, Mandl JN, Orthwein A

Molecular and cellular biology2024Senior author

DOI: 10.1080/10985549.2023.2290434 PMID: 38270191

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.

Pinedo-Carpio E, Dessapt J, Beneyton A, Sacre L, Bérubé MA, Villot R, Lavoie EG, Coulombe Y, Blondeau A, Boulais J, Malina A, Luo VM, Lazaratos AM, Côté JF, Mallette FA, Guarné A, Masson JY, Fradet-Turcotte A, Orthwein A

Science advances2023Senior author

DOI: 10.1126/sciadv.adf4082 PMID: 37556550

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

Findlay S, Nair R, Merrill RA, Kaiser Z, Cajelot A, Aryanpour Z, Heath J, St-Louis C, Papadopoli D, Topisirovic I, St-Pierre J, Sebag M, Kesarwala AH, Hulea L, Taylor EB, Shanmugam M, Orthwein A

Blood advances2023Senior author

DOI: 10.1182/bloodadvances.2022008345 PMID: 36920785

B cell-specific knockout of AID protects against atherosclerosis.

Ebrahimian T, Dierick F, Ta V, Kotsiopriftis M, O'Connor Miranda J, Mann KK, Orthwein A, Lehoux S

Scientific reports2023

DOI: 10.1038/s41598-023-35980-1 PMID: 37253865

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

Fooks K, Galicia-Vazquez G, Gife V, Schcolnik-Cabrera A, Nouhi Z, Poon WWL, Luo V, Rys RN, Aloyz R, Orthwein A, Johnson NA, Hulea L, Mercier FE

Journal of experimental & clinical cancer research : CR2022

DOI: 10.1186/s13046-022-02542-8 PMID: 36482393

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.

Simo Cheyou E, Boni J, Boulais J, Pinedo-Carpio E, Malina A, Sherill-Rofe D, Luo VM, Goncalves C, Bagci H, Maters A, Cuella-Martin R, Tabach Y, Del Rincon S, Côté JF, Rivera B, Orthwein A

PLoS genetics2022Senior author

DOI: 10.1371/journal.pgen.1010495 PMID: 36374936

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.

Mercier FE, Shi J, Sykes DB, Oki T, Jankovic M, Man CH, Kfoury YS, Miller E, He S, Zhu A, Vasic R, Doench J, Orthwein A, Michor F, Scadden DT

Blood advances2022

DOI: 10.1182/bloodadvances.2022007250 PMID: 35793392

A decade of RAD51C and RAD51D germline variants in cancer.

Boni J, Idani A, Roca C, Feliubadaló L, Tomiak E, Weber E, Foulkes WD, Orthwein A, El Haffaf Z, Lazaro C, Rivera B

Human mutation2022

DOI: 10.1002/humu.24319 PMID: 34923718

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Alexandre Orthwein

Research

Latest papers

Latest funding

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGF&#x3b2; Signaling.

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the &#x3b3;-Subunit Gng2.

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

B cell-specific knockout of AID protects against atherosclerosis.

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.

A decade of RAD51C and RAD51D germline variants in cancer.

Deciphering the role of the E3 ubiquitin ligase HERC1 in the chemotherapy response of acute myeloid leukemia.

Canada Reseach Chair - Tier 2

X-Ray Irradiation Platform for cells and small animal studies

Regulation of DNA double-strand break repair pathways in multiple myeloma

From genetic diversity to genomic instability: in vivo characterization of the deubiquitinase OTUB1 in B-cells

CRC Tier 2

Frequent collaborators

Jean-Yves Masson

Laura Hulea

Graham Dellaire

Eva Tomiak

Anne-Marie Mes-Masson

Stephanie Lehoux

Michael Witcher

Sonia Del Rincon

Ivan Topisirovic

Morag Park

Sonia Del Rincon

Raquel Cuella Martin

Ivan Topisirovic

Sylvie Lesage

Julie St-Pierre

Michael Sebag

Jacek Majewski

Morag Park

François Rousseau

Nancy Braverman

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.