Faculty profile

Simon-Pierre Gravel

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Simon-Pierre Gravel

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (2 NSERC, 1 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Drug Delivery Gene Delivery Lipid Metabolism Nanoparticles Rare Disease

Latest papers

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.
eLife · 2026
Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.
Life science alliance · 2025 · senior author
Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression.
Biomaterials science · 2022

All 21 publications

Latest funding

Design of nanoparticles for the targeted delivery of non-integrating constructs
NSERC · 2023 · Co-investigator
$25,000
Investigating mitochondrial biogenesis rheostat functions in skin aging: stress sensing and control of immunometabolic landscapes
NSERC · 2023 · Principal investigator
$80,000
Long-lasting recovery of lysosomal acid lipase deficiency using non-viral delivery of non-integrating episomal DNA constructs.
CIHR · 2023 · Principal investigator
$661,725

All 6 grants and awards

21 publications.

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.

Lefrançois G, Lavallée E, Rowell MC, Bourdeau V, Mohebali F, Bertomeu T, Duman AM, Nikolova M, Tyers M, Gravel SP, Schmitzer AR, Ferbeyre G

eLife2026

DOI: 10.7554/elife.102680 PMID: 42138716

Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.

Lavallée É, Roulet-Matton M, Giang V, Cardona Hurtado R, Chaput D, Gravel SP

Life science alliance2025Senior author

DOI: 10.26508/lsa.202402912 PMID: 39658088

Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression.

Zadory M, Lopez E, Babity S, Gravel SP, Brambilla D

Biomaterials science2022

DOI: 10.1039/d2bm00859a PMID: 36097955

Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.

Laurin KM, Coutu-Beaudry K, Salazar A, Méribout N, Audet-Walsh É, Gravel SP

Cancer letters2022Senior author

DOI: 10.1016/j.canlet.2022.215738 PMID: 35594996

Immunometabolic modulation of retinal inflammation by CD36 ligand.

Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Pundir S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H

Scientific reports2019

DOI: 10.1038/s41598-019-49472-8 PMID: 31501473

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I

Cell metabolism2018

DOI: 10.1016/j.cmet.2018.09.001 PMID: 30244971

A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response.

Shamalnasab M, Gravel SP, St-Pierre J, Breton L, Jäger S, Aguilaniu H

Aging cell2018

DOI: 10.1111/acel.12830 PMID: 30192051

Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.

Thivierge C, Tseng HW, Mayya VK, Lussier C, Gravel SP, Duchaine TF

Nucleic acids research2018

DOI: 10.1093/nar/gky666 PMID: 30053103

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Im YK, Najyb O, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J

Cancer research2018

DOI: 10.1158/0008-5472.can-17-3696 PMID: 29930100

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP

Cancer research2018

DOI: 10.1158/0008-5472.can-17-2215 PMID: 29440170

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Simon-Pierre Gravel

Research

Latest papers

Latest funding

The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells.

Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 inhibitors.

Current knowledge on the tissue distribution of mRNA nanocarriers for therapeutic protein expression.

Low expression of PGC-1&#x3b2; and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.

Immunometabolic modulation of retinal inflammation by CD36 ligand.

Translational and HIF-1&#x3b1;-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response.

Alternative polyadenylation confers&#xa0;Pten mRNAs stability and resistance to microRNAs.

Interplay between ShcA Signaling and PGC-1&#x3b1; Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Design of nanoparticles for the targeted delivery of non-integrating constructs

Investigating mitochondrial biogenesis rheostat functions in skin aging: stress sensing and control of immunometabolic landscapes

Long-lasting recovery of lysosomal acid lipase deficiency using non-viral delivery of non-integrating episomal DNA constructs.

Investigating mitochondrial biogenesis rheostat functions in skin aging: stress sensing and control of immunometabolic landscapes

Cardioprotective effect of a cyclic azapeptide ligand of CD36 against ischemia-reperfusion damage and dysfunction in mice

Highly versatile benchtop Flow Cytometry Analyzer

Frequent collaborators

Julie St-Pierre

Michael Pollak

Ivan Topisirovic

Ivan Topisirovic

Laura Hulea

Julie St-Pierre

Sylvain Meloche

Arnim Pause

Nathalie Grandvaux

Pierre Thibault

Maria Febbraio

Shawn McGuirk

Sylvie Marleau

Gerardo Ferbeyre

Nahum Sonenberg

Davide Brambilla

Sylvain Chemtob

William Muller

Michael Ohh

Celia Greenwood

Gerardo Ferbeyre

Peter Siegel

Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.