Ruth Slack, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Neurogenesis Aging Mitochondria Amyotrophic Lateral Sclerosis (Als)Frontotemporal Dementia Parkinson'S Disease (Pd)Small Non-Coding Rna Neural Stem Cell

Latest papers

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.
Scientific reports · 2026
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy · 2016
Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.
The Journal of biological chemistry · 2011

All 4 publications

Latest funding

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability
CIHR · 2023 · Co-investigator
$100,000
Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability
CIHR · 2022 · Co-investigator
$100,000
Systems Analysis of novel small non-coding RNA in Stress-Induced Alterations in Transcription and Protein Translation: Towards novel Biomarkers and Therapeutics for Neurodegenerative Disorders (RNA-Neuro)
CIHR · 2017 · Nominated PI
$499,890

All 11 grants and awards

4 publications.

01

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Salazar-Leon J, Freitas-Andrade M, Guadarrama-Perez V, Solari S, Hudak A, Stotts C, Simon N, Geoffrion M, Murray S, Slack R, Lacoste B, Rayner KJ

Scientific reports2026

DOI: 10.1038/s41598-026-54533-w PMID: 42321267

02

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K

Autophagy20165,052 citations

DOI: 10.1080/15548627.2015.1100356

03

Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.

Lira A, Kulczycki J, Slack R, Anisman H, Park DS

The Journal of biological chemistry2011

DOI: 10.1074/jbc.m111.244830 PMID: 21693708

04

Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS

The Journal of neuroscience : the official journal of the Society for Neuroscience2007

DOI: 10.1523/jneurosci.5321-06.2007 PMID: 17376993

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability

Co-investigatorCIHR2023Project Grant - PA: Human Development, Child and Youth Health

Principal investigators: Jahani-Asl, Arezu

Keywords: Ephrin Receptors; Gene Mutation; Receptors; Signalling; Stem Cells; Transcription

$100,000

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability

Co-investigatorCIHR2022Project Grant - PA: Epigenetics/epigenomics in human health or disease

Principal investigators: Jahani-Asl, Arezu

Keywords: Ephrin Receptors; Gene Mutation; Receptors; Signalling; Stem Cells; Transcription

$100,000

Systems Analysis of novel small non-coding RNA in Stress-Induced Alterations in Transcription and Protein Translation: Towards novel Biomarkers and Therapeutics for Neurodegenerative Disorders (RNA-Neuro)

Nominated PICIHR2017Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)

Principal investigators: Slack, Ruth S

Keywords: Amyotrophic Lateral Sclerosis (Als); Frontotemporal Dementia; Parkinson'S Disease (Pd); Small Non-Coding Rna

$499,890

Enhancing Mitochondrial Integrity to Promote Brain Regeneration and Repair

Nominated PICIHR2016Foundation Grant

Principal investigators: Slack, Ruth S

Keywords: Aging; Mitochondria; Neural Stem Cell; Neurodegeneration; Neurogenesis; Stroke

$2,682,655

Canadian Stroke Network (2006 Renewal Competition)

Co-investigatorNSERC2013Networks of Centres of Excellence

Principal investigators: Hakim, Antoine

$500,000

Mitochondrial Dynamics in Adult Neural Precursor Cell Maintenance and Neurogenesis

Nominated PICIHR2013Operating Grant

Principal investigators: Slack, Ruth S

Keywords: Adult Neurogenesis; Aging; Mitochondria; Neural Precusor Cells; Neurodegenerative Diseases

$872,730

The role of the Rb-E2F pathway in adult neurogenesis

Nominated PICIHR2012Operating Grant

Principal investigators: Slack, Ruth S

Keywords: Adult Cell Cycle; Neurogenesis; Progenitor Cells; Transgenic Mice

$921,944

Stem Cell Network/Réseau de cellules souches

Co-investigatorNSERC2012Networks of Centres of Excellence

Principal investigators: Rudnicki, Michael

$2,061,000

Canadian Stroke Network (2006 Renewal Competition)

Co-investigatorNSERC2009Networks of Centres of Excellence

Principal investigators: Hakim, Antoine

$8,361,135

CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training

Co-investigatorCIHR2008Training Grant

Principal investigators: Bennett, Steffany A; Figeys, Daniel

Keywords: Alzheimer And Parkinson'S Disease; Cell Biology; Lipidomics; Mass Spectrometry; Neurodegenerative Disease; Systems Biology

$1,790,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Craig McCormick

Microbiology and Immunology

1 shared papers, latest 2016

Honglin Luo

Pathology and Laboratory Medicine

1 shared papers, latest 2016

Eldad Zacksenhaus

Cellular and Molecular Biology

1 shared papers, latest 2016

Isabella Caniggia

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2016

Xiaoyan Jiang

Terry Fox Laboratory

1 shared papers, latest 2016

Michel Roberge

Biochemistry and Molecular Biology

1 shared papers, latest 2016

Shawn Hayley

Cellular and Molecular Medicine

1 shared papers, latest 2007

Steve Jean

Anatomie et biologie cellulaire

1 shared papers, latest 2016

Shawn Hayley

Neurosciences and Mental Health

1 shared papers, latest 2007

Khosrow Adeli

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2016

Ivan Topisirovic

Lady Davis Institute for Medical Research

1 shared papers, latest 2016

Martin Gleave

Urologic Sciences

1 shared papers, latest 2016

Arnim Pause

Biochemistry

1 shared papers, latest 2016

Baptiste Lacoste

Cellular and Molecular Medicine

1 shared papers, latest 2026

Xi-Long Zheng

Biochemistry and Molecular Biology

1 shared papers, latest 2016

David Grimes

Department of Medicine

1 shared papers, latest 2007

Michael Sacher

Biology

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Neurogenesis Dear Professor Slack, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Ruth Slack

Research

Latest papers

Latest funding

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.

Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability

Transcriptional Regulation of Impaired Neurogenesis in Developmental Disorders of Cognition and Intellectual Disability

Systems Analysis of novel small non-coding RNA in Stress-Induced Alterations in Transcription and Protein Translation: Towards novel Biomarkers and Therapeutics for Neurodegenerative Disorders (RNA-Neuro)

Enhancing Mitochondrial Integrity to Promote Brain Regeneration and Repair

Canadian Stroke Network (2006 Renewal Competition)

Mitochondrial Dynamics in Adult Neural Precursor Cell Maintenance and Neurogenesis

The role of the Rb-E2F pathway in adult neurogenesis

Stem Cell Network/Réseau de cellules souches

Canadian Stroke Network (2006 Renewal Competition)

CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training

Frequent collaborators

Craig McCormick

Honglin Luo

Eldad Zacksenhaus

Isabella Caniggia

Xiaoyan Jiang

Michel Roberge

Shawn Hayley

Steve Jean

Shawn Hayley

Dusica Maysinger

Khosrow Adeli

Ivan Topisirovic

Martin Gleave

Arnim Pause

Baptiste Lacoste

Ivan Topisirovic

Xi-Long Zheng

Urban Emmenegger

David Grimes

Andre Bedard

John Lee

Michael Sacher