Faculty profile

Xi-Long Zheng

ResearcherBiochemistry and Molecular BiologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Xi-Long Zheng

Researcher

Biochemistry and Molecular Biology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
32 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

143

Publications

5,052

Citations

Collaborators

Grants

Publications by year

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Signals and details

Research

Pcsk9 In Vascular Smooth Muscle, Abdominal Aortic Aneurysm Aging

Latest papers

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.
Acta pharmacologica Sinica · 2026
Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression.
Cell proliferation · 2026
Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy.
Acta pharmacologica Sinica · 2026 · senior author

All 143 publications

Latest funding

Characterization of smooth muscle PCSK9 in the pathogenesis of abdominal aortic aneurysm
CIHR · 2021 · Nominated PI
$944,776
Epigenetic Regulation of Phenotypic Plasticity of Vascular Smooth Muscle Cells
NSERC · 2020 · Principal investigator
$216,000
Role of Smooth Muscle Autophagy in Aging-Associated Vascular Stiffness
CIHR · 2019 · Nominated PI
$948,600

All 6 grants and awards

143 publications.

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.

Wen YH, Jiang JX, Dong WY, Guo J, Hu QY, Liu XY, Yang ZZ, Huang LF, Zhu JN, Zhang MZ, Wang XP, Liu YP, Ma N, Zheng XL, Cai WQ, Xu JD, Fang XH, Shan ZX

Acta pharmacologica Sinica2026

DOI: 10.1038/s41401-026-01912-8 PMID: 42637927

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression.

Xia M, Li M, Chen Y, Chen J, Cui Y, Zheng XL, Yang J, Li B, Ma X, Liu M, Fan G, Peng J, Dai X, Tang Z

Cell proliferation2026

DOI: 10.1111/cpr.70244 PMID: 42269711

Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy.

Zhou FL, Wu YB, Wang W, Yan BJ, He YC, Zheng XL

Acta pharmacologica Sinica2026Senior author

DOI: 10.1038/s41401-026-01823-8 PMID: 42252304

Edelfosine induces cell cycle arrest and apoptosis in vascular smooth muscle cells to suppress neointimal hyperplasia.

Sun J, Gui Y, Liu Y, Guo Y, Granado RG, Guetg L, Peng W, Zhou S, Zheng XL

Scientific reports2026Senior author

DOI: 10.1038/s41598-026-44632-z PMID: 41882161

S1UTRSP5, a short restructured RNA from SLIT1 3'UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity.

Su JF, Ou T, Liu XY, Su XM, Wang Y, Wen YH, Gao Y, Li RH, Huang LF, Zhou CM, Zhao HL, Zhu JN, Ma N, Zheng XL, Liu YP, Xu JD, Li H, Fang XH, Shan ZX

Acta pharmacologica Sinica2026

DOI: 10.1038/s41401-026-01859-w PMID: 42277205

Clonal hematopoiesis, inflammaging, and vascular disease: mechanisms, risk stratification, and therapeutic frontiers in older adults.

Zheng XL

Acta pharmacologica Sinica2026First author

DOI: 10.1038/s41401-026-01766-0 PMID: 41840008

Glutaminase 1 in Vascular Disease: Linking Metabolic Reprogramming to Atherosclerosis Progression and Stability.

Zheng XL, Yin H, Tang Z, Shan Z, Dai X

Journal of cardiovascular translational research2026First author

DOI: 10.1007/s12265-026-10743-1 PMID: 41811615

circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis.

Wu HY, Zhou CM, Gao Y, Wen YH, Hu YT, Zhao HL, Dong WY, Liu XY, Zhai L, Li Y, Zhang MZ, Zhu JN, Li H, Xu JD, Ma N, Liu YP, Zheng XL, Fang XH, Shan ZX

Acta pharmacologica Sinica2026

DOI: 10.1038/s41401-025-01620-9 PMID: 40721504

Monomethyl fumarate confers cardioprotection after myocardial infarction via HCAR2-dependent activation of PI3K/Akt signaling.

Zhang Y, Gui Y, Belke D, Wang X, Su W, Liu M, Yan B, Sun J, Hu X, Zheng XL

Cell death discovery2025Senior author

DOI: 10.1038/s41420-025-02927-6 PMID: 41469385

Ginsenoside Rb1 alleviates atherosclerosis by modulating vascular smooth muscle cell proliferation, foam cell formation, and autophagy.

Yuan HH, Yi ZY, Xie LL, Bu LL, Guo MH, Zheng XL

Phytomedicine : international journal of phytotherapy and phytopharmacology2025Senior author

DOI: 10.1016/j.phymed.2025.157503 PMID: 41237446

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Pcsk9 In Vascular Smooth Muscle, Abdominal Aortic Aneurysm Dear Professor Zheng, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Characterization of smooth muscle PCSK9 in the pathogenesis of abdominal aortic aneurysm" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Xi-Long Zheng

Research

Latest papers

Latest funding

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing &#x3b2;-catenin signaling.

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression.

Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy.

Edelfosine induces cell cycle arrest and apoptosis in vascular smooth muscle cells to suppress neointimal hyperplasia.

S1UTRSP5, a short restructured RNA from SLIT1 3'UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity.

Clonal hematopoiesis, inflammaging, and vascular disease: mechanisms, risk stratification, and therapeutic frontiers in older adults.

Glutaminase 1 in Vascular Disease: Linking Metabolic Reprogramming to Atherosclerosis Progression and Stability.

circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis.

Monomethyl fumarate confers cardioprotection after myocardial infarction via HCAR2-dependent activation of PI3K/Akt signaling.

Ginsenoside Rb1 alleviates atherosclerosis by modulating vascular smooth muscle cell proliferation, foam cell formation, and autophagy.

Characterization of smooth muscle PCSK9 in the pathogenesis of abdominal aortic aneurysm

Epigenetic Regulation of Phenotypic Plasticity of Vascular Smooth Muscle Cells

Role of Smooth Muscle Autophagy in Aging-Associated Vascular Stiffness

SRF-independent roles of Myocardin in differentiation of vascular smooth muscle cells

Regulation of Myocardin Activity in Vascular Smooth Muscle by Proteasome Degradation

Polyploidization of vascular smooth muscle cells contributes to vascular aging

Frequent collaborators

Isabella Caniggia

Steve Jean

Michael Sacher

Khosrow Adeli

Honglin Luo

Shashi Gujar

Urban Emmenegger

Liang Li

Yasir Mohamud

Thomas Pulinilkunnil

Ina Dobrinski

Craig McCormick

Caigan Du

Sandra Turcotte

Todd McMullen

Eldad Zacksenhaus

Gary Sweeney

Xiaoyan Jiang

Michel Roberge

Nigil Haroon

Dusica Maysinger

Ivan Topisirovic

Martin Gleave

Sophie Roux

Jean-Jacques Lebrun

Arnim Pause

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.