Faculty profile

Vuk Stambolic

ResearcherResearchUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Vuk Stambolic

Researcher

Research

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2025.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

569

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Signal Transduction Breast Cancer Obesity Bioenergetics Biology Of Cancer Human Models Of Cancer Metabolism Prevention

Latest papers

Association of cancer antigen 15-3 with distant recurrence in immunohistochemically defined breast cancer subtypes in Canadian Cancer Trials Group MA.32.
JNCI cancer spectrum · 2026 · senior author
Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
Cell Reports Medicine · 2026
Exploration of body mass index and circulating metabolic factors as predictors of metformin benefit in the Canadian Cancer Trials Group MA.32
JNCI Cancer Spectrum · 2026 · senior author

All 56 publications

Latest funding

Influence of obesity-related metabolic factors on breast cancer
CIHR · 2025 · Nominated PI
$100,000
The Function of Protein Kinase NEK10 in tumour suppression
CIHR · 2020 · Nominated PI
$1,224,000
Molecular mechanism of insulin receptor action in breast cancer with implications for therapy
CIHR · 2018 · Nominated PI
$956,250

All 7 grants and awards

56 publications.

Association of cancer antigen 15-3 with distant recurrence in immunohistochemically defined breast cancer subtypes in Canadian Cancer Trials Group MA.32.

Goodwin PJ, Chen BE, Gelmon KA, Whelan TJ, Ennis M, Ligibel J, Stos PM, Shepherd LE, Parulekar WR, Stambolic V

JNCI cancer spectrum2026Senior author

DOI: 10.1093/jncics/pkag068 PMID: 42360727

Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target

Govindarajan M, Mejia-Guerrero S, Chafe SC, Khan S, Shi W, Waas M, Rossotti MA, Khoo A, Liu LY, Ignatchenko V

Cell Reports Medicine20262 citations

DOI: 10.1016/j.xcrm.2025.102578

Exploration of body mass index and circulating metabolic factors as predictors of metformin benefit in the Canadian Cancer Trials Group MA.32

Goodwin PJ, Ennis M, Chen BE, Gelmon KA, Whelan TJ, Ligibel JA, Thompson AM, Shepherd LE, Parulekar WR, Dowling R

JNCI Cancer Spectrum2026Senior author

DOI: 10.1093/jncics/pkag045

β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.

Dutt P, Haider N, Mouaaz S, Podmore L, Stambolic V

Proceedings of the National Academy of Sciences of the United States of America2024Senior author

DOI: 10.1073/pnas.2300606121 PMID: 38683979

Insulin receptor loss impairs mammary tumorigenesis in mice.

Podmore L, Poloz Y, Iorio C, Mouaaz S, Nixon K, Smirnov P, McDonnell B, Lam S, Zhang B, Tharmapalan P, Sarkar S, Vyas F, Ennis M, Dowling R, Stambolic V

Cell reports2023Senior author

DOI: 10.1016/j.celrep.2023.113251 PMID: 37913774

Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer

Goodwin PJ, Chen BE, Gelmon KA, Whelan TJ, Ennis M, Lemieux J, Ligibel JA, Hershman DL, Mayer IA, Hobday TJ

Journal of Clinical Oncology202331 citationsOpen Access

DOI: 10.1200/jco.23.00296 PMID: W4386608505

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy.

Mirsanaye K, Uribe Castaño L, Kamaliddin Y, Golaraei A, Augulis R, Kontenis L, Done SJ, Žurauskas E, Stambolic V, Wilson BC, Barzda V

Scientific reports2022

DOI: 10.1038/s41598-022-13623-1 PMID: 35717344

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer

Goodwin PJ, Chen BE, Gelmon KA, Whelan TJ, Ennis M, Lemieux J, Ligibel JA, Hershman DL, Mayer IA, Hobday TJ

Journal of the American Medical Association (JAMA)2022244 citationsOpen Access

DOI: 10.1001/jama.2022.6147 PMID: W4282916913

Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.

Fortin J, Bassi C, Ramachandran P, Li WY, Tian R, Zarrabi I, Hill G, Snow BE, Haight J, Tobin C, Hodgson K, Wakeham A, Stambolic V, Mak TW

The Journal of clinical investigation2021

DOI: 10.1172/jci131698 PMID: 33444287

The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.

Bassi C, Fortin J, Snow BE, Wakeham A, Ho J, Haight J, You-Ten A, Cianci E, Buckler L, Gorrini C, Stambolic V, Mak TW

Cell death and differentiation2021

DOI: 10.1038/s41418-021-00799-8 PMID: 34059798

Influence of obesity-related metabolic factors on breast cancer

Nominated PICIHR2025Project Grant - PA - Breast Cancer Prevention & Early Detection

Principal investigators: Stambolic, Vuk

Keywords: Bioenergetics; Biology Of Cancer; Breast Cancer; Human Models Of Cancer; Metabolism; Obesity; Prevention; Signal Transduction; Treatment

$100,000

The Function of Protein Kinase NEK10 in tumour suppression

Nominated PICIHR2020Project Grant

Principal investigators: Stambolic, Vuk

Keywords: Breast Cancer; Broad Cancer Spectrum; Cancer; Direct Phosphorylation; Genotoxic Agents Sensitivity; Loss Or Gain Of Function; Nek10; P53; Patient Stratification; Protein Kinase

$1,224,000

Molecular mechanism of insulin receptor action in breast cancer with implications for therapy

Nominated PICIHR2018Project Grant

Principal investigators: Stambolic, Vuk

Keywords: Breast Cancer; Cell Biology And Biochemistry; Insulin Receptor; Molecular Mechanism; Mouse Transgenic And Knockout Models; Obesity; Receptor Crosstalk; Retrospective Analysis Of Clinical Trials; Signal Transduction; Xenograft

$956,250

Nuclear PTEN function in tumor suppression

Nominated PICIHR2014Operating Grant

Principal investigators: Stambolic, Vuk

Keywords: Dna Repair; Mouse Models Of Cancer; Nuclear Function; Pten; Response To Genotoxic Stress; Sensitivity To Cancer Treatment; Signal Transduction; Tumor Suppressor

$626,592

Identification of a molecular profile predictive of metformin sensitivity in human breast cancer.

SupervisorCIHR2010Banting Postdoctoral Fellowship Program

Principal investigators: Dowling, Ryan J

Keywords: Cancer Treatment; Cell Proliferation; Cell Signalling; Immunohistochemistry; Metabolism; Molecular Biology; Oncology; Processing Tissue Samples; Tissue/Cell Culture; Tumour Biology

$140,000

Functional characterization of the NIMA-related kinase 10 (Nek10) in development and disease

Nominated PICIHR2010Operating Grant - Priority Announcement: Breast Cancer

Principal investigators: Stambolic, Vuk

Keywords: Animal Models Of Cancer; Cancer; Knockout Mice; Nek10; Phosphorylation; Signal Transduction

$481,140

The Terry Fox Foundation Strategic Training Initiative for Excellence in Radiation Research for the 21st Century (EIRR21) at CIHR

Co-investigatorCIHR2008Terry Fox Foundation Training Grant in Cancer Research at CIHR -Full application

Principal investigators: Liu, Fei-Fei

Keywords: Capacity Building; Innovation; Leadership Skills; Radiation Research; Trans-Disciplinarity

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Vuk Stambolic

Research

Latest papers

Latest funding

Association of cancer antigen 15-3 with distant recurrence in immunohistochemically defined breast cancer subtypes in Canadian Cancer Trials Group MA.32.

Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target

Exploration of body mass index and circulating metabolic factors as predictors of metformin benefit in the Canadian Cancer Trials Group MA.32

&#x3b2;-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.

Insulin receptor loss impairs mammary tumorigenesis in mice.

Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy.

Effect of Metformin vs Placebo on Invasive Disease–Free Survival in Patients With Breast Cancer

Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy.

The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer.

Influence of obesity-related metabolic factors on breast cancer

The Function of Protein Kinase NEK10 in tumour suppression

Molecular mechanism of insulin receptor action in breast cancer with implications for therapy

Nuclear PTEN function in tumor suppression

Identification of a molecular profile predictive of metformin sensitivity in human breast cancer.

Functional characterization of the NIMA-related kinase 10 (Nek10) in development and disease

The Terry Fox Foundation Strategic Training Initiative for Excellence in Radiation Research for the 21st Century (EIRR21) at CIHR

Frequent collaborators

Timothy Whelan

Mitsuhiko Ikura

Lily Zhou

Daniel Schramek

Chiara Gorrini

Eitan Amir

Robert Rottapel

Som Mukherjee

Tak Mak

Rama Khokha

Eldad Zacksenhaus

Michael Reedijk

Wendy Parulekar

Ivan Topisirovic

Josef Penninger

Ahmed Aman

Philippe Bedard

Warren Foltz

Pingzhao Hu

Wei Xu

Ivan Topisirovic

Louise Larose

Daniela Rotin

Amira Klip

David Litchfield

Virginijus Barzda

Srikala Sridhar

Helen McNeill

Sheila Singh

Ming-Sound Tsao

Andrea Molckovsky

Thomas Kislinger

Minna Woo

Fei-Fei Liu

Laurie Ailles

β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.