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Alain Gratton

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Retired ProfessorDepartment of PsychiatryMcGill University

Alain Gratton

Retired Professor

Department of Psychiatry

Faculty of Medicine and Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
3 publications in the last five years, latest in 2024.
Principal investigator on 7 research grants (4 NSERC, 3 CIHR), most recently in 2011.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,875

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their McGill University profile.

Neuroscience

Latest papers

Testing PET-[ 11 C]ABP688 as a tool to quantify glutamate release in vivo.
Imaging neuroscience (Cambridge, Mass.) · 2024
Investigating the "two-hit hypothesis": Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice.
Progress in neuro-psychopharmacology & biological psychiatry · 2023
Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.
Psychopharmacology · 2023

All 27 publications

Latest funding

Sex-dependent effects of early life stress on the development of the basolateral amygdala-prefrontal cortex circuit for fear conditioning
CIHR · 2018 · Co-investigator
$761,175
Central effects of stress
CIHR · 2011 · Nominated PI
$628,552
Molecular biomarkers of antidepressant response
CIHR · 2010 · Co-investigator
$1,096,567

All 11 grants and awards

27 publications.

Testing PET-[ 11 C]ABP688 as a tool to quantify glutamate release in vivo.

Bdair H, Sato-Fitoussi M, Planche S, Moquin L, Kang MS, Aliaga A, Nagano-Saito A, Smart K, Cox SML, Near J, Aguilar-Valles A, Massarweh G, Rosa-Neto P, Benkelfat C, Soucy JP, Kostikov A, Gratton A, Leyton M

Imaging neuroscience (Cambridge, Mass.)20244 citationsOpen Access

DOI: 10.1162/imag_a_00126 PMID: 40800322

Investigating the "two-hit hypothesis": Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice.

Guma E, Cupo L, Ma W, Gallino D, Moquin L, Gratton A, Devenyi GA, Chakravarty MM

Progress in neuro-psychopharmacology & biological psychiatry202329 citations

DOI: 10.1016/j.pnpbp.2022.110642 PMID: 36150422

Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.

Darcq E, Nouel D, Hernandez G, Pokinko M, Ash P, Moquin L, Gratton A, Kieffer B, Flores C

Psychopharmacology20232 citationsOpen Access

DOI: 10.1007/s00213-022-06288-1 PMID: 36471064

Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.

Bell S, McCarty V, Peng H, Jefri M, Hettige N, Antonyan L, Crapper L, O'Leary LA, Zhang X, Zhang Y, Wu H, Sutcliffe D, Kolobova I, Rosenberger TA, Moquin L, Gratton A, Popic J, Gantois I, Stumpf PS, Schuppert AA, Mechawar N, Sonenberg N, Tremblay ML, Jinnah HA, Ernst C

Stem cell reports202149 citationsOpen Access

DOI: 10.1016/j.stemcr.2021.06.003 PMID: 34214487

Mice with dopaminergic neuron-specific deletion of DTNBP-1 gene show blunted nucleus accumbens dopamine release and associated behaviors.

Bhardwaj SK, Cui Q, Moquin L, Gratton A, Giros B, Srivastava LK

Neuropharmacology20216 citations

DOI: 10.1016/j.neuropharm.2020.108440 PMID: 33340529

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.

Favier M, Janickova H, Justo D, Kljakic O, Runtz L, Natsheh JY, Pascoal TA, Germann J, Gallino D, Kang JI, Meng XQ, Antinora C, Raulic S, Jacobsen JP, Moquin L, Vigneault E, Gratton A, Caron MG, Duriez P, Brandon MP, Neto PR, Chakravarty MM, Herzallah MM, Gorwood P, Prado MA, Prado VF, El Mestikawy S

The Journal of clinical investigation202057 citationsOpen Access

DOI: 10.1172/jci138532 PMID: 33164988

Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells.

Jefri M, Bell S, Peng H, Hettige N, Maussion G, Soubannier V, Wu H, Silveira H, Theroux JF, Moquin L, Zhang X, Aouabed Z, Krishnan J, O'Leary LA, Antonyan L, Zhang Y, McCarty V, Mechawar N, Gratton A, Schuppert A, Durcan TM, Fon EA, Ernst C

Stem cells translational medicine202031 citationsOpen Access

DOI: 10.1002/sctm.18-0180 PMID: 32154672

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

Sami Ben Hamida, Sueli Mendonça-Netto, Tanzil Mahmud Arefin, Md Taufiq Nasseef, Laura‐Joy Boulos, Michael McNicholas, Aliza T. Ehrlich, Eleanor Clarke, Luc Moquin, Alain P. Gratton, Emmanuel Darcq, Laura Adela Harsan, Rafaël Maldonado, Brigitte Lina Kieffer

Biological Psychiatry201860 citationsOpen Access

DOI: 10.1016/j.biopsych.2018.01.026 PMID: 29580570

Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson's disease motor symptoms without neuronal degeneration in adult mice.

Isingrini E, Guinaudie C, C Perret L, Rainer Q, Moquin L, Gratton A, Giros B

Scientific reports201717 citationsOpen Access

DOI: 10.1038/s41598-017-12810-9 PMID: 28963508

Interhemispheric regulation of the rat medial prefrontal cortical glutamate stress response: role of local GABA- and dopamine-sensitive mechanisms.

Lupinsky D, Moquin L, Gratton A

Psychopharmacology2017Senior author

DOI: 10.1007/s00213-016-4468-6 PMID: 27822602

Sex-dependent effects of early life stress on the development of the basolateral amygdala-prefrontal cortex circuit for fear conditioning

Co-investigatorCIHR2018Project Grant

Principal investigators: Walker, Claire-Dominique

Keywords: Development Of Projections; Early Life Stress; Electrophysiology; Fear Conditioning; Microglia; Morphology; Neonatal Amygdala; Prefrontal Cortex; Sex Steroid Receptors; Sexual Dimorphism

$761,175

Central effects of stress

Nominated PICIHR2011Operating Grant

Principal investigators: Gratton, Alain

Keywords: Coping; Dopamine; Glutamate; Medial Prefrontal Cortex; Microdialysis; Rats; Stress; Voltammetry

$628,552

Molecular biomarkers of antidepressant response

Co-investigatorCIHR2010Operating Grant

Principal investigators: Turecki, Gustavo X

Keywords: Antidepressants; Major Depression; Microrna; Mrna; Neurobiology

$1,096,567

Birth insult and the development of medial prefrontal cortical function

Nominated PICIHR2009Operating Grant

Principal investigators: Gratton, Alain

Keywords: Dopamine; Glutamate; Medial Prefrontal Cortex; Microdialysis; Perinatal Anoxia; Voltammetry

$695,206

Role of microRNA in Major Depression and Suicide

Co-investigatorCIHR2008Operating Grant

Principal investigators: Turecki, Gustavo X

Keywords: Major Depression; Microrna; Neurobiology; Suicide; Vulnerability

$767,298

Birth insult and the development of medial prefrontal cortical function

Nominated PICIHR2008Operating Grant - PA: INMHA (bridge funding)

Principal investigators: Gratton, Alain

Keywords: Dopamine; Glutamate; Medial Prefrontal Cortex; Microdialysis; Perinatal Anoxia; Voltammetry

$100,000

Electrochemical monitoring of dopamine in the rat brain

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Gratton, Alain

$165,535

Electrochemical monitoring of dipamine in the rat brain

Principal investigatorNSERC2002Discovery Grants Program - Individual

Principal investigators: Gratton, Alain

$160,000

Centre de recherche et d'innovation en santé mentale à l'Hôpital Douglas

Co-investigatorCFI1999Innovation Fund: Institutional Innovation Fund over $350,000

Principal investigators: Quirion, Remi

Keywords: santé mentale, recherche clinique de pointe, recherche biomédicale novatrice, incubateurs d'entreprises

$2,007,600

In vivo electrochemical monitoring of dopamine in the rat brain

Principal investigatorNSERC1998Discovery Grants Program - Individual

Principal investigators: Gratton, Alain

$86,735

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Alain Gratton

Research

Latest papers

Latest funding

Testing PET-[ 11 C]ABP688 as a tool to quantify glutamate release in vivo.

Investigating the "two-hit hypothesis": Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice.

Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.

Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.

Mice with dopaminergic neuron-specific deletion of DTNBP-1 gene show blunted nucleus accumbens dopamine release and associated behaviors.

Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.

Stimulation of L-type calcium channels increases tyrosine hydroxylase and dopamine in ventral midbrain cells induced from somatic cells.

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks

Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson's disease motor symptoms without neuronal degeneration in adult mice.

Interhemispheric regulation of the rat medial prefrontal cortical glutamate stress response: role of local GABA- and dopamine-sensitive mechanisms.

Sex-dependent effects of early life stress on the development of the basolateral amygdala-prefrontal cortex circuit for fear conditioning

Central effects of stress

Molecular biomarkers of antidepressant response

Birth insult and the development of medial prefrontal cortical function

Role of microRNA in Major Depression and Suicide

Birth insult and the development of medial prefrontal cortical function

Electrochemical monitoring of dopamine in the rat brain

Electrochemical monitoring of dipamine in the rat brain

Centre de recherche et d'innovation en santé mentale à l'Hôpital Douglas

In vivo electrochemical monitoring of dopamine in the rat brain

Frequent collaborators

Bruno Giros

Naguib Mechawar

Brigitte Kieffer

Carl Ernst

Pedro Rosa-Neto

Jean-Paul Soucy

Lalit Srivastava

Mallar Chakravarty

Cecilia Flores

Claire-Dominique Walker

Gustavo Turecki

Marco Leyton

Liam Crapper

Michel Tremblay

Mark Brandon

Jamie Near

Maia Kokoeva

Kai-Florian Storch

Thomas Durcan

Bénédicte Amilhon

Kelly Smart