Elliot Drobetsky, Université de Montréal

Research

Nucleotide Excision Repair Chemoresistance Ovarian Cancer Cell Cycle Flow Cytometry Dna Damage Signaling Dna Double Strand Break Repair Dna Replication Stress

Latest papers

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21.
The Journal of biological chemistry · 2023 · senior author
Opto-magnetic capture of individual cells based on visual phenotypes.
eLife · 2019
Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells.
Cancer research · 2018 · senior author

All 8 publications

Latest funding

Single-stranded DNA generation during UV-induced replicative stress in skin cancer
CIHR · 2024 · Co-investigator
$845,326
Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer
CIHR · 2021 · Nominated PI
$929,475
A system for automated high-content screening and laser manipulation of single cells.
NSERC · 2019 · Co-investigator
$127,074

All 15 grants and awards

8 publications.

01

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21.

Bélanger F, Roussel C, Sawchyn C, St-Hilaire E, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Mallette FA, Wurtele H, Drobetsky E

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2023.104900 PMID: 37301510

02

Opto-magnetic capture of individual cells based on visual phenotypes.

Binan L, Bélanger F, Uriarte M, Lemay JF, Pelletier De Koninck JC, Roy J, Affar EB, Drobetsky E, Wurtele H, Costantino S

eLife2019

DOI: 10.7554/elife.45239 PMID: 30969169

03

Replication Protein A Availability during DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells.

Bélanger F, Fortier E, Dubé M, Lemay JF, Buisson R, Masson JY, Elsherbiny A, Costantino S, Carmona E, Mes-Masson AM, Wurtele H, Drobetsky E

Cancer research2018Senior author

DOI: 10.1158/0008-5472.can-18-0618 PMID: 30072396

04

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation.

Collin R, St-Pierre C, Guilbault L, Mullins-Dansereau V, Policheni A, Guimont-Desrochers F, Pelletier AN, Gray DH, Drobetsky E, Perreault C, Hillhouse EE, Lesage S

Journal of immunology (Baltimore, Md. : 1950)2017

DOI: 10.4049/jimmunol.1600789 PMID: 28710252

05

Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair.

Bélanger F, Angers JP, Fortier É, Hammond-Martel I, Costantino S, Drobetsky E, Wurtele H

The Journal of biological chemistry2016

DOI: 10.1074/jbc.m115.685883 PMID: 26578521

06

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.

Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont PL, Drobetsky E, Nepveu A

Nucleic acids research2012

DOI: 10.1093/nar/gks041 PMID: 22319212

07

Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters.

Ross J, Bottardi S, Bourgoin V, Wollenschlaeger A, Drobetsky E, Trudel M, Milot E

Nucleic acids research2009

DOI: 10.1093/nar/gkp545 PMID: 19567738

08

Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis.

Azam S, Drobetsky E, Ramotar D

Apoptosis : an international journal on programmed cell death2007

DOI: 10.1007/s10495-006-0050-8 PMID: 17333320

Single-stranded DNA generation during UV-induced replicative stress in skin cancer

Co-investigatorCIHR2024Project Grant

Principal investigators: Wurtele, Hugo

Keywords: Biochemistry; Cell Biology; Crispr-Cas9 Screening; Dna Repair; Dna Replication; Gene Expression Profiling; Genetics; Mutagenesis; Skin Cancer; Uv-Induced Replicative Stress

$845,326

Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer

Nominated PICIHR2021Project Grant

Principal investigators: Drobetsky, Elliot A

Keywords: Chemoresistance; Dna Damage Signaling; Dna Double Strand Break Repair; Dna Replication Stress; Nucleotide Excision Repair; Ovarian Cancer

$929,475

A system for automated high-content screening and laser manipulation of single cells.

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Costantino, Santiago

$127,074

Modulation of UV damage repair by replicative stress-induced RPA exhaustion during skin cancer development

Co-investigatorCIHR2017Project Grant

Principal investigators: Wurtele, Hugo

Keywords: Dna Repair; Dna Replication; Genetic Determinants Of Cancer; Melanoma; Mutagenesis; Nucleotide Excision Repair

$791,775

Identification of novel replication stress response modulators through genome-wide CRISPR/Cas9 screens.

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Lemay, Jean-François

Keywords: Cancer; Cellular Biology; Crispr/Cas9; Dna Damage; Dna Repair; Flow Cytometry; Genome Integrity; High-Troughput Screening; Replication Stress; Synthetic Lethality

$135,000

Identification of therapeutic targets for pediatric acute megakaryoblastic leukemia

Co-investigatorCIHR2017Project Grant

Principal investigators: Mallette, Frédérick A; Melichar, Heather

Keywords: Cellular Signaling; Crispr/Cas9 Screens; Genomics; Leukemic Gene Fusions; Mouse Model Of Leukemia; Oncogene Cooperation; Pediatric Acute Megakaryoblastic Leukemia; Progenitor Cell; Proteomics; Transcriptomics

$765,000

A Benchtop Cell Sorter for Accelerating the Discovery of Physiopathological Processes

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Milot, ERIC

$146,629

A novel mechanism of chemoresistance in ovarian cancer cells

Nominated PICIHR2016Project Grant

Principal investigators: Drobetsky, Elliot A

Keywords: Cell Cycle; Chemoresistance; Dna Repair; Flow Cytometry; Ovarian Cancer; Replicative Stress Response

$565,731

Cell Cycle-Specific Regulation of Nucleotide Excision Repair in S. Cerevisiae

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Drobetsky, Elliot

$210,000

Regulation of UV Damage Repair by the ATR-mediated DNA Damage Checkpoint in Malignant Melanoma

Nominated PICIHR2013Operating Grant

Principal investigators: Drobetsky, Elliot A

Keywords: Atr Kinase; Cell Cycle; Confocal Microscopy; Dna Sequencing; Flow Cytometry; Genomic Instability; Malignant Melanoma; Nucleotide Excision Repair; Q-Rt-Pcr

$364,536

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Centre de recherche
Oncology
Institut de recherche en immunologie et cancer
Medicine/Oncology
Engineering Physics
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Hugo Wurtele

Centre de recherche

4 shared papers, latest 2023

Santiago Costantino

Faculty

1 shared papers, latest 2019

Alain Nepveu

Oncology

1 shared papers, latest 2012

Marie Trudel

Medicine

1 shared papers, latest 2009

Sylvie Lesage

Faculty

1 shared papers, latest 2017

Dindial Ramotar

Medicine/Oncology

1 shared papers, latest 2007

Claude Perreault

Institut de recherche en immunologie et cancer

1 shared papers, latest 2017

Eric Milot

Medicine

1 shared papers, latest 2009

Santiago Costantino

Engineering Physics

1 shared papers, latest 2019

Jean-Yves Masson

Faculty

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Nucleotide Excision Repair Dear Professor Drobetsky, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]