Faculty profile

Shawn McGuirk

ResearcherMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses and email address may be missing. Find their university profile.

Shawn McGuirk

Researcher

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2023.
Principal investigator on 2 research grants (2 CIHR), most recently in 2017.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Dissemination Public Education Science Policy Drug Policy Medical And Recreational Marijuana Opioid Crisis Public Forum Student-Driven Initiative

Latest papers

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.
Cell reports · 2023
PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.
iScience · 2023
HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.
Oncogene · 2022

All 16 publications

Latest funding

Opioids and Cannabinoids in Canada: a public forum series on current research, social impact, and regulation
CIHR · 2017 · Nominated PI
$12,000
Genomics Policy Public Forum
CIHR · 2016 · Nominated PI
$4,500

All 2 grants and awards

16 publications.

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.

Audet-Delage Y, St-Louis C, Minarrieta L, McGuirk S, Kurreal I, Annis MG, Mer AS, Siegel PM, St-Pierre J

Cell reports2023

DOI: 10.1016/j.celrep.2023.113191 PMID: 37792528

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

Gravel SP, Ben Khalifa Y, McGuirk S, St-Louis C, Laurin KM, Lavallée É, Benas D, Desbouis S, Amaral F, D'Amours D, Breton L, Jäger S, St-Pierre J

iScience2023

DOI: 10.1016/j.isci.2023.106314 PMID: 37009228

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.

Biondini M, Kiepas A, El-Houjeiri L, Annis MG, Hsu BE, Fortier AM, Morin G, Martina JA, Sirois I, Aguilar-Mahecha A, Gruosso T, McGuirk S, Rose AAN, Tokat UM, Johnson RM, Sahin O, Bareke E, St-Pierre J, Park M, Basik M, Majewski J, Puertollano R, Pause A, Huang S, Keler T, Siegel PM

Oncogene2022

DOI: 10.1038/s41388-022-02206-z PMID: 35110681

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.

McGuirk S, Audet-Delage Y, Annis MG, Xue Y, Vernier M, Zhao K, St-Louis C, Minarrieta L, Patten DA, Morin G, Greenwood CM, Giguère V, Huang S, Siegel PM, St-Pierre J

eLife2021First author

DOI: 10.7554/elife.65150 PMID: 34181531

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Patten DA, McGuirk S, Anilkumar U, Antoun G, Gandhi K, Parmar G, Iqbal MA, Wong J, Richardson RB, St-Pierre J, Slack RS, Harper ME

Biochimica et biophysica acta. Molecular cell research2021

DOI: 10.1016/j.bbamcr.2020.118854 PMID: 32926942

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.

Vernier M, McGuirk S, Dufour CR, Wan L, Audet-Walsh E, St-Pierre J, Giguère V

Oncogene2020

DOI: 10.1038/s41388-020-01438-1 PMID: 32855526

Estrogen-related receptors are targetable ROS sensors.

Vernier M, Dufour CR, McGuirk S, Scholtes C, Li X, Bourmeau G, Kuasne H, Park M, St-Pierre J, Audet-Walsh E, Giguère V

Genes & development2020

DOI: 10.1101/gad.330746.119 PMID: 32079653

Metabolic Fitness and Plasticity in Cancer Progression.

McGuirk S, Audet-Delage Y, St-Pierre J

Trends in cancer2020First author

DOI: 10.1016/j.trecan.2019.11.009 PMID: 31952781

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Gill JF, Delezie J, Santos G, McGuirk S, Schnyder S, Frank S, Rausch M, St-Pierre J, Handschin C

Aging cell2019

DOI: 10.1111/acel.12993 PMID: 31290266

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Im YK, Najyb O, Gravel SP, McGuirk S, Ahn R, Avizonis DZ, Chénard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak M, St-Pierre J, Ursini-Siegel J

Cancer research2018

DOI: 10.1158/0008-5472.can-17-3696 PMID: 29930100

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Shawn McGuirk

Research

Latest papers

Latest funding

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.

Estrogen-related receptors are targetable ROS sensors.

Metabolic Fitness and Plasticity in Cancer Progression.

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Opioids and Cannabinoids in Canada: a public forum series on current research, social impact, and regulation

Genomics Policy Public Forum

Frequent collaborators

Julie St-Pierre

Julie St-Pierre

Ivan Topisirovic

Sidong Huang

Morag Park

Ivan Topisirovic

Michael Pollak

Damien D'Amours

Étienne Audet-Walsh

Laura Hulea

Morag Park

Simon-Pierre Gravel

Mark Basik

Arnim Pause

Nahum Sonenberg

Mary-Ellen Harper

Jacek Majewski

Shawn McGuirk

Research

Latest papers

Latest funding

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Inhibition of DNMT1 and ERR&#x3b1; crosstalk suppresses breast cancer via derepression of IRF4.

Estrogen-related receptors are targetable ROS sensors.

Metabolic Fitness and Plasticity in Cancer Progression.

Peroxisome proliferator-activated receptor &#x3b3; coactivator 1&#x3b1; regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Interplay between ShcA Signaling and PGC-1&#x3b1; Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Opioids and Cannabinoids in Canada: a public forum series on current research, social impact, and regulation

Genomics Policy Public Forum

Frequent collaborators

Julie St-Pierre

Julie St-Pierre

Ivan Topisirovic

Sidong Huang

Morag Park

Ivan Topisirovic

Michael Pollak

Damien D'Amours

Étienne Audet-Walsh

Laura Hulea

Morag Park

Simon-Pierre Gravel

Mark Basik

Arnim Pause

Nahum Sonenberg

Mary-Ellen Harper

Jacek Majewski

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.