Damien D'Amours, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Chromosome Condensation Condensin Genome Integrity Mitosis Crc Casein Kinase Cyclin-Dependent Kinase Polo Kinase

Latest papers

Microtubule-dependent regulation of chromatin dynamics by the Smc5/6 complex.
iScience · 2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
Production and Purification of the Human SMC5/6 Core Complex from S. cerevisiae.
Methods in molecular biology (Clifton, N.J.) · 2026 · senior author

All 23 publications

Latest funding

Mitotic regulation of the Condensin complex
CIHR · 2026 · Nominated PI
$1,063,350
Canada Research Chair - Tier 1
CIHR · 2024 · Nominated PI
$1,400,000
Regulation of chromosome architecture by SMC complexes in health and disease
CIHR · 2018 · Nominated PI
$2,490,878

All 5 grants and awards

23 publications.

01

Microtubule-dependent regulation of chromatin dynamics by the Smc5/6 complex.

Carré-Simon À, Martuzzi C, Isler S, Batrin R, Pinholt HD, Földes T, Laflamme G, Reguera J, Barbi M, Mirny L, D'Amours D, Fabre E

iScience2026

DOI: 10.1016/j.isci.2026.116943 PMID: 42597752

02

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

03

Production and Purification of the Human SMC5/6 Core Complex from S. cerevisiae.

Adhikary H, D'Amours D

Methods in molecular biology (Clifton, N.J.)2026Senior author

DOI: 10.1007/978-1-0716-5005-9_15 PMID: 41111114

04

Protocol for detecting interactions between intrinsically disordered proteins and long DNA substrates by electrophoretic mobility shift assay.

Pastic A, Kochhar A, D'Amours D

STAR protocols2025Senior author

DOI: 10.1016/j.xpro.2025.103968 PMID: 40705594

05

Yeast centrosomes act as organizing centers to promote Polo kinase-mediated adaptation to persistent DNA damage.

Langlois-Lemay L, D'Amours D

Proceedings of the National Academy of Sciences of the United States of America2025Senior author

DOI: 10.1073/pnas.2414426122 PMID: 40601630

06

The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2.

Roy S, Adhikary H, Isler S, D'Amours D

eLife2024Senior author

DOI: 10.7554/elife.96626 PMID: 39404251

07

Chromosome compaction is triggered by an autonomous DNA-binding module within condensin.

Pastic A, Nosella ML, Kochhar A, Liu ZH, Forman-Kay JD, D'Amours D

Cell reports2024Senior author

DOI: 10.1016/j.celrep.2024.114419 PMID: 38985672

08

The SMC5/6 complex: folding chromosomes back into shape when genomes take a break.

Roy S, Adhikary H, D'Amours D

Nucleic acids research2024Senior author

DOI: 10.1093/nar/gkae103 PMID: 38375830

09

Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature.

Bhola PT, Mishra R, Posey JE, Hamilton LE, Graham GE, Punetha J, Care4Rare Canada Consortium, Lupski JR, Boycott KM, D'Amours D, Kernohan KD

American journal of medical genetics. Part A2024Senior author

DOI: 10.1002/ajmg.a.63455 PMID: 37921537

10

Editorial: Reviews and advances in our understanding of the relationship between the cell cycle, DNA damage and cancer.

D'Amours D

Frontiers in cell and developmental biology2023First author

DOI: 10.3389/fcell.2023.1333628 PMID: 38046669