Santiago Costantino

Research

1101 Human Health 1102 Biomedical Engineering 1901 Biomedical Technology Age-Related Macular Degeneration 2006 Biomaterials Corneal Endothelial Dystrophies Femtosecond Laser Gene Therapy

Latest papers

Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients.
Documenta ophthalmologica. Advances in ophthalmology · 2026
A new approach for high-content traction force microscopy to characterize large cell ensembles.
Biophysical journal · 2026 · senior author
Focus on numbers - characterizing protein accumulation at DNA double-strand breaks.
Journal of cell science · 2025 · senior author

All 46 publications

Latest funding

Selective laser-mediated gene therapy for ocular diseases
CIHR · 2017 · Principal investigator
$369,433
Nanoplasmonics Enhanced Laser Gene Delivery for Retinal Degenerative Diseases
CIHR · 2012 · Principal investigator
$269,000

All 2 grants and awards

46 publications.

01

Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients.

Polosa A, Lu M, Dorfman AL, Masis-Solano M, Costantino S, Qian CX

Documenta ophthalmologica. Advances in ophthalmology2026

DOI: 10.1007/s10633-025-10064-9 PMID: 41222609

02

A new approach for high-content traction force microscopy to characterize large cell ensembles.

Desjardins-Lecavalier N, Costantino S

Biophysical journal2026Senior author

DOI: 10.1016/j.bpj.2025.11.013 PMID: 41229119

03

Focus on numbers - characterizing protein accumulation at DNA double-strand breaks.

Modica G, Roy J, Godin AG, Wurtele H, Costantino S

Journal of cell science2025Senior author

DOI: 10.1242/jcs.263483 PMID: 40309929

04

Ocular Biomechanical Responses to Long-Duration Spaceflight.

Solano MM, Dumas R, Lesk MR, Costantino S

IEEE open journal of engineering in medicine and biology2025Senior author

DOI: 10.1109/ojemb.2024.3453049 PMID: 39698125

05

The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity.

Sayah DN, Descovich D, Costantino S, Lesk MR

Ophthalmology science2024

DOI: 10.1016/j.xops.2024.100576 PMID: 39253552

06

Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.

Masís Solano M, Richer E, Costantino S, Lesk MR

Bioengineering (Basel, Switzerland)2024

DOI: 10.3390/bioengineering11050411 PMID: 38790278

07

Denoising OCT videos based on temporal redundancy.

Richer E, Solano MM, Cheriet F, Lesk MR, Costantino S

Scientific reports2024Senior author

DOI: 10.1038/s41598-024-56935-0 PMID: 38503804

08

Migration speed of captured breast cancer subpopulations correlates with metastatic fitness.

Desjardins-Lecavalier N, Annis MG, Nowakowski A, Kiepas A, Binan L, Roy J, Modica G, Hébert S, Kleinman CL, Siegel PM, Costantino S

Journal of cell science2023Senior author

DOI: 10.1242/jcs.260835 PMID: 37313743

09

Laser-Assisted Single-Cell Labeling and Capture.

Desjardins-Lecavalier N, Modica G, Costantino S

Methods in molecular biology (Clifton, N.J.)2023Senior author

DOI: 10.1007/978-1-0716-2914-7_21 PMID: 36587135

10

Mapping Pulsatile Optic Nerve Head Deformation Using OCT.

Solano MM, Richer E, Cheriet F, Lesk MR, Costantino S

Ophthalmology science2022Senior author

DOI: 10.1016/j.xops.2022.100205 PMID: 36531582

Selective laser-mediated gene therapy for ocular diseases

Principal investigatorCIHR2017Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Meunier, Michel; Côté, Christian-Yves; Brunette, Isabelle; Costantino, Santiago; Sapieha, Przemyslaw (Mike) S

Keywords: 1101 Human Health; 1102 Biomedical Engineering; 1901 Biomedical Technology; 2006 Biomaterials; Age-Related Macular Degeneration; Corneal Endothelial Dystrophies; Femtosecond Laser; Gene Therapy; Gold Nanoparticles; Laser Transfection

$369,433

Nanoplasmonics Enhanced Laser Gene Delivery for Retinal Degenerative Diseases

Principal investigatorCIHR2012Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Meunier, Michel; Costantino, Santiago; Sapieha, Przemyslaw (Mike) S

Keywords: 1101 Human Health; 1102 Biomedical Engineering; 1901 Biomedical Technology; Age-Related Macular Degeneration; Cell Transfection; Glaucoma; Laser Therapy; Plasmonic Nanoparticles; Retinitis Pigmentosa; Retinotherapy

$269,000

Institut de recherche en immunologie et cancer

1 shared papers, latest 2015

Nada Jabado

Pediatrics

1 shared papers, latest 2019

Pierre Lachapelle

Medical Genetics

1 shared papers, latest 2011

Michel Meunier

Engineering Physics

1 shared papers, latest 2018

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Subject: Prospective PhD student: 1101 Human Health Dear Professor Costantino, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]