Alain Verreault, Université de Montréal

Research

Chromatin Deacetylation Dna Damage Dna Repair Histone Nucleosome Sirtuin Crc

Latest papers

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
Unorthodox PCNA Binding by Chromatin Assembly Factor 1.
International journal of molecular sciences · 2022 · senior author
Chromatin dynamics and DNA replication roadblocks.
DNA repair · 2021

All 10 publications

Latest funding

Histone protein supply and demand: life on a knife's edge
NSERC · 2019 · Principal investigator
$406,800
CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1
CIHR · 2012 · Nominated PI
$1,400,000
Histone Deacetylation and the DNA Damage Response
CIHR · 2012 · Nominated PI
$100,000

All 5 grants and awards

10 publications.

01

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

02

Unorthodox PCNA Binding by Chromatin Assembly Factor 1.

Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden KLB, Omichinski JG, Verreault A

International journal of molecular sciences2022Senior author

DOI: 10.3390/ijms231911099 PMID: 36232396

03

Chromatin dynamics and DNA replication roadblocks.

Hammond-Martel I, Verreault A, Wurtele H

DNA repair2021

DOI: 10.1016/j.dnarep.2021.103140 PMID: 34087728

04

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Côté J

Molecular cell2017

DOI: 10.1016/j.molcel.2016.10.033 PMID: 27916662

05

Production and Purification of Antibodies Against Histone Modifications.

Guillemette B, Hammond-Martel I, Wurtele H, Verreault A

Methods in molecular biology (Clifton, N.J.)2017Senior author

DOI: 10.1007/978-1-4939-6630-1_9 PMID: 27854020

06

The LMO2 oncogene regulates DNA replication in hematopoietic cells.

Sincennes MC, Humbert M, Grondin B, Lisi V, Veiga DF, Haman A, Cazaux C, Mashtalir N, Affar el B, Verreault A, Hoang T

Proceedings of the National Academy of Sciences of the United States of America2016

DOI: 10.1073/pnas.1515071113 PMID: 26764384

07

Interplay between histone H3 lysine 56 deacetylation and chromatin modifiers in response to DNA damage.

Simoneau A, Delgoshaie N, Celic I, Dai J, Abshiru N, Costantino S, Thibault P, Boeke JD, Verreault A, Wurtele H

Genetics2015

DOI: 10.1534/genetics.115.175919 PMID: 25786853

08

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.

Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond M

Nature medicine2010

DOI: 10.1038/nm.2175 PMID: 20601951

09

Enhanced protein detection using a trapping mode on a hybrid quadrupole linear ion trap (Q-Trap).

Drogaris P, Le Blanc JC, Fitzgerald JE, Lowndes NF, Verreault A, Thibault P

Analytical chemistry2009

DOI: 10.1021/ac9004259 PMID: 20337398

10

Histone post-translational modifications and the response to DNA double-strand breaks.

Wurtele H, Verreault A

Current opinion in cell biology2006Senior author

DOI: 10.1016/j.ceb.2006.02.008 PMID: 16487697

Histone protein supply and demand: life on a knife's edge

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Verreault, Alain

$406,800

CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1

Nominated PICIHR2012Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Verreault, Alain

Keywords: Crc

$1,400,000

Histone Deacetylation and the DNA Damage Response

Nominated PICIHR2012Operating Grant - PA: Cancer Research (bridge funding)

Principal investigators: Verreault, Alain

Keywords: Chromatin; Deacetylation; Dna Damage; Dna Repair; Histone; Nucleosome; Sirtuin

$100,000

Histone Deacetylation and the DNA Damage Response

Nominated PICIHR2012Operating Grant

Principal investigators: Verreault, Alain

Keywords: Chromatin; Deacetylation; Dna Damage; Dna Repair; Histone; Nucleosome; Sirtuin

$540,410

Control of newly synthesized histone deacetylation and its implications for the clinical use of HDAC inhibitors

Co-investigatorNSERC2010Collaborative Health Research Projects

Principal investigators: Thibault, Pierre

$220,951

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Ivan Topisirovic and Ivan Topisirovic: 77 shared papers
Santiago Costantino and Santiago Costantino: 46 shared papers
Sylvie Mader and Sylvie Mader: 24 shared papers
Anne-Claude Gingras and Brian Raught: 21 shared papers
Frank Sicheri and Anne-Claude Gingras: 18 shared papers
Guy Sauvageau and Anne Marinier: 8 shared papers
Sylvain Meloche and Pierre Thibault: 7 shared papers
Frank Sicheri and Marc Therrien: 6 shared papers
Guy Sauvageau and Pierre Thibault: 6 shared papers
Frank Sicheri and Brian Raught: 5 shared papers
Guy Sauvageau and Sylvain Meloche: 5 shared papers
Frank Sicheri and Anne Marinier: 4 shared papers
Hugo Wurtele and Alain Verreault: 4 shared papers
Alain Verreault and Pierre Thibault: 4 shared papers
Guy Sauvageau and Trang Hoang: 4 shared papers
Hugo Wurtele and Santiago Costantino: 3 shared papers
Hugo Wurtele and Santiago Costantino: 3 shared papers
Vincent Archambault and Pierre Thibault: 3 shared papers
Ivan Topisirovic and Sylvain Meloche: 3 shared papers
Marc Therrien and Pierre Thibault: 3 shared papers
Anne Marinier and Sylvain Meloche: 3 shared papers
Sylvain Meloche and Ivan Topisirovic: 3 shared papers
Sylvie Mader and Pierre Thibault: 2 shared papers
Alain Verreault and Trang Hoang: 2 shared papers
Sylvie Mader and Pierre Thibault: 2 shared papers
Ivan Topisirovic and Pierre Thibault: 2 shared papers
Anne Marinier and Trang Hoang: 2 shared papers
Ivan Topisirovic and Pierre Thibault: 2 shared papers
Frank Sicheri and Sylvie Mader: 1 shared paper
Frank Sicheri and Alain Verreault: 1 shared paper
Frank Sicheri and Sylvie Mader: 1 shared paper
Frank Sicheri and Vincent Archambault: 1 shared paper
Frank Sicheri and Damien D'Amours: 1 shared paper
Anne-Claude Gingras and Alain Verreault: 1 shared paper
Anne-Claude Gingras and Jean-François Couture: 1 shared paper
Anne-Claude Gingras and Marc Therrien: 1 shared paper
Sylvie Mader and Alain Verreault: 1 shared paper
Sylvie Mader and Vincent Archambault: 1 shared paper
Sylvie Mader and Brian Raught: 1 shared paper
Sylvie Mader and Damien D'Amours: 1 shared paper
Alain Verreault and Santiago Costantino: 1 shared paper
Alain Verreault and Sylvie Mader: 1 shared paper
Alain Verreault and Vincent Archambault: 1 shared paper
Alain Verreault and Brian Raught: 1 shared paper
Alain Verreault and Jean-François Couture: 1 shared paper
Alain Verreault and Santiago Costantino: 1 shared paper
Alain Verreault and Guy Sauvageau: 1 shared paper
Alain Verreault and Ivan Topisirovic: 1 shared paper
Alain Verreault and Marc Therrien: 1 shared paper
Alain Verreault and Anne Marinier: 1 shared paper
Alain Verreault and Sylvain Meloche: 1 shared paper
Alain Verreault and Damien D'Amours: 1 shared paper
Alain Verreault and Ivan Topisirovic: 1 shared paper

Institut de recherche en immunologie et cancer
Biochimie et médecine moléculaire
Centre de recherche
Pharmacology
Chemistry
Department of Molecular Genetics
Research Institute
Other

Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: Chromatin Dear Professor Verreault, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Histone protein supply and demand: life on a knife's edge" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]