Santiago Costantino

Research

Biomechanics Glaucoma Ocular Rigidity Optical Coherence Tomography Vision Science Dynamic Ocular Oct Imaging Glaucoma Detection Image Analysis

Latest papers

Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients.
Documenta ophthalmologica. Advances in ophthalmology · 2026
A new approach for high-content traction force microscopy to characterize large cell ensembles.
Biophysical journal · 2026 · senior author
Focus on numbers - characterizing protein accumulation at DNA double-strand breaks.
Journal of cell science · 2025 · senior author

All 46 publications

Latest funding

IMAGE-GUIDED INJECTION WITH A HIGH-RESOLUTION ULTRASOUND SYSTEM ADAPTED FOR RODENT USE
NSERC · 2022 · Co-investigator
$146,541
Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer
CIHR · 2021 · Co-investigator
$929,475
Local and global biomechanical properties of the eye as new glaucoma risk factors
CIHR · 2021 · Nominated PI
$692,326

All 18 grants and awards

46 publications.

01

Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients.

Polosa A, Lu M, Dorfman AL, Masis-Solano M, Costantino S, Qian CX

Documenta ophthalmologica. Advances in ophthalmology2026

DOI: 10.1007/s10633-025-10064-9 PMID: 41222609

02

A new approach for high-content traction force microscopy to characterize large cell ensembles.

Desjardins-Lecavalier N, Costantino S

Biophysical journal2026Senior author

DOI: 10.1016/j.bpj.2025.11.013 PMID: 41229119

03

Focus on numbers - characterizing protein accumulation at DNA double-strand breaks.

Modica G, Roy J, Godin AG, Wurtele H, Costantino S

Journal of cell science2025Senior author

DOI: 10.1242/jcs.263483 PMID: 40309929

04

Ocular Biomechanical Responses to Long-Duration Spaceflight.

Solano MM, Dumas R, Lesk MR, Costantino S

IEEE open journal of engineering in medicine and biology2025Senior author

DOI: 10.1109/ojemb.2024.3453049 PMID: 39698125

05

The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity.

Sayah DN, Descovich D, Costantino S, Lesk MR

Ophthalmology science2024

DOI: 10.1016/j.xops.2024.100576 PMID: 39253552

06

Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.

Masís Solano M, Richer E, Costantino S, Lesk MR

Bioengineering (Basel, Switzerland)2024

DOI: 10.3390/bioengineering11050411 PMID: 38790278

07

Denoising OCT videos based on temporal redundancy.

Richer E, Solano MM, Cheriet F, Lesk MR, Costantino S

Scientific reports2024Senior author

DOI: 10.1038/s41598-024-56935-0 PMID: 38503804

08

Migration speed of captured breast cancer subpopulations correlates with metastatic fitness.

Desjardins-Lecavalier N, Annis MG, Nowakowski A, Kiepas A, Binan L, Roy J, Modica G, Hébert S, Kleinman CL, Siegel PM, Costantino S

Journal of cell science2023Senior author

DOI: 10.1242/jcs.260835 PMID: 37313743

09

Laser-Assisted Single-Cell Labeling and Capture.

Desjardins-Lecavalier N, Modica G, Costantino S

Methods in molecular biology (Clifton, N.J.)2023Senior author

DOI: 10.1007/978-1-0716-2914-7_21 PMID: 36587135

10

Mapping Pulsatile Optic Nerve Head Deformation Using OCT.

Solano MM, Richer E, Cheriet F, Lesk MR, Costantino S

Ophthalmology science2022Senior author

DOI: 10.1016/j.xops.2022.100205 PMID: 36531582

IMAGE-GUIDED INJECTION WITH A HIGH-RESOLUTION ULTRASOUND SYSTEM ADAPTED FOR RODENT USE

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Lesage, Sylvie

$146,541

Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer

Co-investigatorCIHR2021Project Grant

Principal investigators: Drobetsky, Elliot A

Keywords: Chemoresistance; Dna Damage Signaling; Dna Double Strand Break Repair; Dna Replication Stress; Nucleotide Excision Repair; Ovarian Cancer

$929,475

Local and global biomechanical properties of the eye as new glaucoma risk factors

Nominated PICIHR2021Project Grant

Principal investigators: Costantino, Santiago; Lesk, Mark R

Keywords: Biomechanics; Glaucoma; Ocular Rigidity; Optical Coherence Tomography; Vision Science

$692,326

Single Cell Optical Manipulations

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Costantino, Santiago

$164,000

A system for automated high-content screening and laser manipulation of single cells.

Principal investigatorNSERC2019Research Tools and Instruments

Principal investigators: Costantino, Santiago

$127,074

Selective laser-mediated gene therapy for ocular diseases

Co-investigatorNSERC2018Collaborative Health Research Projects

Principal investigators: Meunier, Michel

$374,183

Operations and Maintenance Support of the Neurophotonics Centre

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: DeKoninck, Yves

$150,000

Development of innovative optical technologies for quantitative blood perfusion imaging

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Dehaes, Mathieu

$141,442

Laser-assisted substrate and cell membrane functionalization

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Costantino, Santiago

$190,000

Development of novel OCT-based clinical measurements of ocular elasticity and retinal deformation as risk factors in glaucoma.

Nominated PICIHR2013Operating Grant

Principal investigators: Costantino, Santiago; Lesk, Mark R

Keywords: Dynamic Ocular Oct Imaging; Glaucoma Detection; Image Analysis; Image Segmentation; Lamina Cribrosa; Ocular Biomechanics; Ocular Tissue Elasticity; Retinal Deformation

$511,724

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Santiago Costantino

Engineering Physics

46 shared papers, latest 2026

Przemyslaw Sapieha

Ophthalmology

3 shared papers, latest 2018

Hugo Wurtele

Centre de recherche

3 shared papers, latest 2025

Przemyslaw Sapieha

Engineering Physics

3 shared papers, latest 2018

Farida Cheriet

Computer Engineering

2 shared papers, latest 2024

Isabelle Brunette

Engineering Physics

2 shared papers, latest 2014

Isabelle Brunette

Ophthalmology

2 shared papers, latest 2014

Guillaume Bourque

Human Genetics

1 shared papers, latest 2019

Valérie Larouche

Pediatric Hematology/Oncology

1 shared papers, latest 2019

Gilles Hickson

Pathologie et biologie cellulaire

1 shared papers, latest 2011

Amit Bar-Or

Rheumatology

1 shared papers, latest 2008

Michel Meunier

Engineering Physics

1 shared papers, latest 2018

Michael Buschmann

Chemical Engineering

1 shared papers, latest 2014

Alain Verreault

Institut de recherche en immunologie et cancer

1 shared papers, latest 2015

Pierre Lachapelle

Medical Genetics

1 shared papers, latest 2011

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Biomechanics Dear Professor Costantino, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Local and global biomechanical properties of the eye as new glaucoma risk factors" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Santiago Costantino

Research

Latest papers

Latest funding

Characterization of functional and structural impairments in best vitelliform macular dystrophy using visual electrophysiology and optical coherence tomography in pediatric and adult patients.

A new approach for high-content traction force microscopy to characterize large cell ensembles.

Focus on numbers - characterizing protein accumulation at DNA double-strand breaks.

Ocular Biomechanical Responses to Long-Duration Spaceflight.

The Association between the Pulsatile Choroidal Volume Change and Ocular Rigidity.

Optic Nerve Head Pulsatile Displacement in Open-Angle Glaucoma after Intraocular Pressure Reduction Measured by Optical Coherence Tomography: A Pilot Study.

Denoising OCT videos based on temporal redundancy.

Migration speed of captured breast cancer subpopulations correlates with metastatic fitness.

Laser-Assisted Single-Cell Labeling and Capture.

Mapping Pulsatile Optic Nerve Head Deformation Using OCT.

IMAGE-GUIDED INJECTION WITH A HIGH-RESOLUTION ULTRASOUND SYSTEM ADAPTED FOR RODENT USE

Replicative stress as a primary determinant of chemotherapeutic outcome in ovarian cancer

Local and global biomechanical properties of the eye as new glaucoma risk factors

Single Cell Optical Manipulations

A system for automated high-content screening and laser manipulation of single cells.

Selective laser-mediated gene therapy for ocular diseases

Operations and Maintenance Support of the Neurophotonics Centre

Development of innovative optical technologies for quantitative blood perfusion imaging

Laser-assisted substrate and cell membrane functionalization

Development of novel OCT-based clinical measurements of ocular elasticity and retinal deformation as risk factors in glaucoma.

Frequent collaborators

Santiago Costantino

Przemyslaw Sapieha

Hugo Wurtele

Przemyslaw Sapieha

Farida Cheriet

Isabelle Brunette

Sylvain Chemtob

Isabelle Brunette

Guillaume Bourque

Valérie Larouche

Livia Garzia

Corina Nagy

Yves De Koninck

Pierre Thibault

Gilles Hickson

Amit Bar-Or

Michel Meunier

Elliot Drobetsky

Michael Buschmann

Gustavo Turecki

Nada Jabado

Alain Verreault

Pierre Lachapelle