Brian Wilhelm, Université de Montréal

Research

Bioinformatic analysis Computational predictions Conserved protein functional domains Genetic variation Genome biology Genome evolution High-throughput functional assays Reporter assays

Latest papers

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Nature genetics · 2015
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.
Blood · 2014

All 4 publications

Latest funding

Characterisation of Bone Marrow Stromal Cell-Mediated Chemo-resistance in Acute Myeloid Leukemia using in vitro Co-culture
CIHR · 2025 · Supervisor
$120,000
Establishing an optimized protocol for introducing mRNA CRISPR constructs into primary human cells
NSERC · 2023 · Principal investigator
$25,000
Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias
CIHR · 2022 · Co-investigator
$891,225

All 9 grants and awards

4 publications.

01

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

02

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G

Nature genetics2015

DOI: 10.1038/ng.3371 PMID: 26237430

03

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

Buscarlet M, Krasteva V, Ho L, Simon C, Hébert J, Wilhelm B, Crabtree GR, Sauvageau G, Thibault P, Lessard JA

Blood2014

DOI: 10.1182/blood-2013-02-483495 PMID: 24478402

04

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.

Simon C, Chagraoui J, Krosl J, Gendron P, Wilhelm B, Lemieux S, Boucher G, Chagnon P, Drouin S, Lambert R, Rondeau C, Bilodeau A, Lavallée S, Sauvageau M, Hébert J, Sauvageau G

Genes & development2012

DOI: 10.1101/gad.186411.111 PMID: 22431509

Characterisation of Bone Marrow Stromal Cell-Mediated Chemo-resistance in Acute Myeloid Leukemia using in vitro Co-culture

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Lussier, Tyler E

Keywords: Acute Myeloid Leukemia; Bone Marrow Microenvironment; Cell-Cell Interactions; Co-Culture; Drug Resistance; Flow Cytometry; High-Throughput Screening; Pediatric Leukemias; Targeted Crispr Screen; Transcriptomics

$120,000

Establishing an optimized protocol for introducing mRNA CRISPR constructs into primary human cells

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Wilhelm, Brian BT

Keywords: cellular differentation; CRISPR; ERG; GATA2; gene enhancers; hematopoietic stem cells; mRNA/RNP transduction; transcriptional regulation

$25,000

Role of the RAS Pathway Activation on the Biology and Drug Response of Acute Myeloid Leukemias

Co-investigatorCIHR2022Project Grant

Principal investigators: Barabé, Frédéric

Keywords: Clonal Evolution; Crispr Induced Gene Mutation; Engineered Human Leukemia Models; Gene Expression Profiles; Human Acute Leukemias; Kmt2a Fusion Gene; Leukemic Stem Cell Frequency; Ras Pathway; Small Molecule High-Throughput Screen; Xenograft Models

$891,225