Faculty profile

Guy Sauvageau

ResearcherInstitut de recherche en immunologie et cancerUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Guy Sauvageau

Researcher

Institut de recherche en immunologie et cancer

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
23 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (10 CIHR, 1 NSERC), most recently in 2026.
Supervisor on 7 trainee awards (7 CIHR), most recently in 2017.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Hsc Transplantation Corest Degradation Cul3-Kbtbd4 E3 Ligase Epigenetic Analyses Hematopoietic Stem Cells (Hsc)Acute Myeloid Leukemia Antibody Drug Conjugate Antigen De-Epitoping

Latest papers

CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy · 2026 · senior author
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
Comparison of Outcomes after UM171-Expanded Cord Blood and Six Conventional Donor Source Transplants: A Matched Analysis from the EBMT Registry.
Transplantation and cellular therapy · 2025

All 87 publications

Latest funding

UM171-mediated Epigenetic Rejuvenation of Aged Human Hematopoietic Stem Cells
CIHR · 2026 · Nominated PI
$1,143,676
Epitope Subtraction to Enable General Plus Subtype-Specific Antibody-Drug Conjugate Targeting in Aggressive AML
CIHR · 2026 · Nominated PI
$1,147,500
Canadian HIV Cure Enterprise 3.0: Targeting tissue HIV reservoirs
CIHR · 2024 · Co-investigator
$3,750,000

All 25 grants and awards

87 publications.

CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy.

Lehnertz B, Langouët M, Corneau S, MacRae T, Joe M, Schmidt EN, Spinella JF, Mayotte N, Moore S, Tellechea MF, Boivin I, Papineau L, Rojas-Sutterlin S, Tual M, Cortes CJ, Chagraoui J, Tomellini E, Desse V, Gagnon E, Macauley MS, Sauvageau G

Molecular therapy : the journal of the American Society of Gene Therapy2026Senior author

DOI: 10.1016/j.ymthe.2025.11.010 PMID: 41220177

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

Comparison of Outcomes after UM171-Expanded Cord Blood and Six Conventional Donor Source Transplants: A Matched Analysis from the EBMT Registry.

Cohen S, Labopin M, Bambace N, Ahmad I, Dumont-Lagacé M, Ciceri F, McLornan DP, Labussière-Wallet H, Kröger N, de Latour RP, Chalandon Y, Forcade E, Cluzeau T, Jindra P, Kulagin A, Roy J, Lachance S, Barabé F, Caudrelier P, Sauvageau G, Yakoub-Agha I, Mohty M

Transplantation and cellular therapy2025

DOI: 10.1016/j.jtct.2025.08.006 PMID: 40818826

Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls.

Laflamme R, Lisi V, Hébert J, Sauvageau G, Lemieux S, Lavallée VP, Lettre G

Blood neoplasia2025

DOI: 10.1016/j.bneo.2025.100118 PMID: 40746938

DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition.

Moison C, Mendoza-Sanchez R, Gracias D, Schuetz DA, Spinella JF, Girard S, Thavonekham B, Chagraoui J, Durand A, Fortier S, MacRae T, Bonneil E, Rose Y, Mayotte N, Boivin I, Thibault P, Hébert J, Ruel R, Marinier A, Sauvageau G

EMBO reports2025Senior author

DOI: 10.1038/s44319-025-00448-y PMID: 40295725

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes.

Kaya F, Bewicke-Copley F, Miettinen JJ, Casado P, Leddy E, Deniz Ö, Lavallée VP, Philippe C, Zheng J, Grebien F, Khan N, Krizsán S, Saad J, Nolin-Lapalme A, Hébert J, Lemieux S, Audemard E, Matthews J, Grantham M, Di Bella D, Wennerberg K, Parsons A, Gribben J, Cavenagh JD, Freeman SD, Bödör C, Sauvageau G, Wang J, Llamas-Sillero P, Cazier JB, Taussig DC, Bonnet D, Cutillas PR, Heckman CA, Fitzgibbon J, Rouault-Pierre K, Rio-Machin A

Leukemia2025

DOI: 10.1038/s41375-025-02593-8 PMID: 40204893

IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia.

Métois A, Bordeleau ME, Theret L, Hajmirza A, Moujaber O, Spinella JF, Chagraoui J, Mayotte N, Boivin I, Audemard É, Aubert L, Lisi V, Khakipoor B, Farah A, Bonneil É, Robert A, Lippens J, Moraitis A, Béliveau F, Feghaly A, Boucher G, Marcotte R, Gendron P, Thibault P, Lemieux S, Richard-Carpentier G, Lavallée VP, Hébert J, Roux PP, Sauvageau G

Biomarker research2025Senior author

DOI: 10.1186/s40364-025-00769-z PMID: 40229904

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis.

Coulombe P, Tomellini E, Chagraoui J, Mayotte N, Sauvageau G

Nature communications2025Senior author

DOI: 10.1038/s41467-024-55225-7 PMID: 39747844

UM171 enhances fitness and engraftment of gene-modified hematopoietic stem cells from patients with sickle cell disease.

Liu B, Klatt D, Zhou Y, Manis JP, Sauvageau G, Pellin D, Brendel C, Williams DA

Blood advances2024

DOI: 10.1182/bloodadvances.2024013932 PMID: 39293082

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML.

Grenier JMP, Testut C, Bal M, Bardin F, De Grandis M, Gelsi-Boyer V, Vernerey J, Delahaye M, Granjeaud S, Zemmour C, Spinella JF, Chavakis T, Mancini SJC, Boher JM, Hébert J, Sauvageau G, Vey N, Schwaller J, Hospital MA, Fauriat C, Aurrand-Lions M

Blood advances2024

DOI: 10.1182/bloodadvances.2023011747 PMID: 38954834

UM171-mediated Epigenetic Rejuvenation of Aged Human Hematopoietic Stem Cells

Nominated PICIHR2026Project Grant

Principal investigators: Sauvageau, Guy

Keywords: Corest Degradation; Cul3-Kbtbd4 E3 Ligase; Epigenetic Analyses; Hematopoietic Stem Cells (Hsc); Hsc Transplantation

$1,143,676

Epitope Subtraction to Enable General Plus Subtype-Specific Antibody-Drug Conjugate Targeting in Aggressive AML

Nominated PICIHR2026Project Grant

Principal investigators: Sauvageau, Guy

Keywords: Acute Myeloid Leukemia; Antibody Drug Conjugate; Antigen De-Epitoping; Crispr Based Base Editing; Hsc Transplantation

$1,147,500

Canadian HIV Cure Enterprise 3.0: Targeting tissue HIV reservoirs

Co-investigatorCIHR2024TG: Biomedical Res. for HIV/AIDS/STBBI-Next-Gen.Therapeutic Interv.-Large Team

Principal investigators: Chomont, Nicolas; Margolese, Shari L; Ancuta, Petronela; Angel, Jonathan B; Cohen, Eric A; Costiniuk, Cecilia T; Murooka, Thomas T

Keywords: Cd4 T Cells; Hiv Cure; Hiv Immunity; Hiv Persistence; Hiv Reservoir; Human Studies; Humanized Mouse Models; Myeloid Cells; Therapeutic Interventions; Tissue

$3,750,000

Distilled-DEL: A novel DNA-encoded drug discovery platform enabling biological evaluation of cellular targets on live cells.

Co-investigatorCIHR2024Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Marinier, Anne

Keywords: Biased Signaling; Breast Cancer; Cancer Therapeutics; Cell-Based Screens; Dna-Encoded Chemical Libraries (Decl); Drug Discovery; Early Hits Identification; G-Protein Coupled Receptors (Gpcrs); Stem Cell Epigenetics; Target Identification And Active Site Mapping

$100,000

Understanding the GR/PLZF axis in acute myeloid leukemia

Nominated PICIHR2021Project Grant

Principal investigators: Sauvageau, Guy

Keywords: Acute Myeloid Leukemia (Aml); Glucocorticoids; Hematological Diseases Treatment; Runx1 Mutations

$908,438

KBTBD4 determines key epigenetic marks that govern human hematopoietic stem cell self-renewal

Nominated PICIHR2021Project Grant

Principal investigators: Sauvageau, Guy

Keywords: Corest Complex; Epigenetic Modifiers; Hsc Self-Renewal Agonist Um171; Human Hematopoietic Stem Cells Renewal; Protein Degradation

$1,032,750

Innovative characterization of structural variants and differential splicing from RNA-sequencing data of 452 primary human AML specimens.

SupervisorCIHR2017CIHR Fellowship

Principal investigators: Spinella, Jean-François

Keywords: Acute Myeloid Leukemia; Biomarkers; Cancer; Differential Splicing; Genomic; Machine Learning; Rna-Sequencing; Structural Variants

$135,000

A functional surfaceome map of human hematopoietic stem and progenitor cells

Co-investigatorCIHR2016Project Grant

Principal investigators: Roux, Philippe

Keywords: Cell Surface Molecules; Cord Blood; Hematopoietic Stem Cells; Leukemia; Stem Cell Markers; Surfaceome; Transplantation; Um171

$1,044,225

Assessing the therapeutic potential of E4F1, a new protein of the DNA damage response, in cancer treatment.

SupervisorCIHR2015CIHR Fellowship

Principal investigators: Moison, Céline

Keywords: Cancer Therapy; Chk1; Confocal Microscopy; Dna Damage Pathway; E4f1; Leukemia; Primary Tumor Samples; Proteomics

$82,500

Clinical application of a novel molecule that expands human cord blood stem cells

Principal investigatorCIHR2014Operating Grant

Principal investigators: Roy, Jean; Cohen, Sandra; Sauvageau, Guy

Keywords: Cord Blood Transplantation; Fed Batch Culture System; Hematopoietic Stem Cell Expansion; Novel Agonist Of Stem Cell Renewal; Phase I Clinical Study

$1,013,167

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Guy Sauvageau

Research

Latest papers

Latest funding

CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Comparison of Outcomes after UM171-Expanded Cord Blood and Six Conventional Donor Source Transplants: A Matched Analysis from the EBMT Registry.

Replication of a GWAS signal near HLA-DQA2 with AML using a disease-only cohort and external population-based controls.

DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition.

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes.

IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia.

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis.

UM171 enhances fitness and engraftment of gene-modified hematopoietic stem cells from patients with sickle cell disease.

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML.

Frequent collaborators

Sandra Cohen

Jean Roy

Claude Perreault

Denis-Claude Roy

Anne Marinier

Lambert Busque

Martin Sauvageau

Pierre Thibault

Sonia Cellot

Sylvain Meloche

Trang Hoang

Julie Lessard

Jean-Yves Masson

David Ogez

Ivan Topisirovic

Marc Therrien

Damien D'Amours

Ivan Topisirovic

Francis Rodier

Sylvie Mader

Guillaume Lettre

Brian Raught

Kolja Eppert

Etienne Gagnon

Vincent Archambault

Frank Sicheri

Michael Sebag

Carl Hansen

Sylvie Mader

Alain Verreault