Faculty profile

Marc Therrien

ResearcherUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Marc Therrien

Researcher

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (10 CIHR, 1 NSERC), most recently in 2024.
Supervised 4 trainees who won CIHR awards, most recently in 2012.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Structural Biology Cell Signalling Kinases Ras-Erk Signalling Crc Signal Transduction Cell-Based Signalling Assays Cryo-Em

Latest papers

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
RAS signaling gets granular.
Nature chemical biology · 2025 · senior author
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nature structural & molecular biology · 2024 · senior author

All 24 publications

Latest funding

Structure-function analysis of RAF-containing complexes
CIHR · 2024 · Nominated PI
$875,925
Characterization of human CNK and KSR proteins in cancer cell motility
CIHR · 2024 · Nominated PI
$1,081,918
Canada Research Chair - Tier 1
CIHR · 2023 · Nominated PI
$1,400,000

All 17 grants and awards

24 publications.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

RAS signaling gets granular.

Lavoie H, Therrien M

Nature chemical biology2025Senior author

DOI: 10.1038/s41589-025-01851-1 PMID: 40038477

The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.

Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrançois M, Kurinov I, Fronzes R, Sicheri F, Therrien M

Nature structural & molecular biology2024Senior author

DOI: 10.1038/s41594-024-01233-6 PMID: 38388830

CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.

Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, Saba-El-Leil MK, Meloche S, Emery G, Therrien M

Nature communications2023Senior author

DOI: 10.1038/s41467-023-39281-z PMID: 37322019

Functional characterization of a PROTAC directed against BRAF mutant V600E.

Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F

Nature chemical biology2020

DOI: 10.1038/s41589-020-0609-7 PMID: 32778845

ERK signalling: a master regulator of cell behaviour, life and fate.

Lavoie H, Gagnon J, Therrien M

Nature reviews. Molecular cell biology2020Senior author

DOI: 10.1038/s41580-020-0255-7 PMID: 32576977

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F

American journal of medical genetics. Part A2018

DOI: 10.1002/ajmg.a.40632 PMID: 30302932

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.

Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB

Nature communications2018

DOI: 10.1038/s41467-018-06854-2 PMID: 30349006

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Jin T, Lavoie H, Sahmi M, David M, Hilt C, Hammell A, Therrien M

Nature communications2017Senior author

DOI: 10.1038/s41467-017-01274-0 PMID: 29084939

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.

Kubiniok P, Lavoie H, Therrien M, Thibault P

Molecular & cellular proteomics : MCP2017

DOI: 10.1074/mcp.m116.065128 PMID: 28188228

Structure-function analysis of RAF-containing complexes

Nominated PICIHR2024Project Grant

Principal investigators: Therrien, Marc

Keywords: Cell Signalling; Cell-Based Signalling Assays; Cryo-Em; Gtpases; Kinases; Ras-Erk Signalling; Structural Biology

$875,925

Characterization of human CNK and KSR proteins in cancer cell motility

Nominated PICIHR2024Project Grant

Principal investigators: Therrien, Marc

Keywords: Cell Migration And Invasion; Cell Signalling; Kinases; Mechanisms Of Celllular Metastasis; Ras-Erk Signalling; Rho Signalling; Rtk Signalling; Scaffolding Proteins; Small Gtpases

$1,081,918

Canada Research Chair - Tier 1

Nominated PICIHR2023Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Therrien, Marc

Keywords: Crc

$1,400,000

Control of MAPK levels in Drosophila

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Therrien, Marc

$360,000

RAS-MAPK signal transduction in normal and cancer cells

Nominated PICIHR2017Foundation Grant

Principal investigators: Therrien, Marc

Keywords: Signal Transduction

$3,273,064

Canada Research Chair - Tier 1

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Therrien, Marc

Keywords: Crc

$1,400,000

Development of small molecule modulators of Ras signaling

Co-investigatorCIHR2016Project Grant

Principal investigators: Marinier, Anne

Keywords: Computer-Assisted Drug Design; Macrocyclic Peptidomimetics; Protein-Protein Interactions; Ras Signaling; Ras-Erk Pathway; Ras-Raf Interaction; Small Molecule Inhibitors

$860,625

Intra and intermolecular interactions regulating RAF family members

Nominated PICIHR2016Project Grant

Principal investigators: Therrien, Marc

Keywords: Allosteric Regulation; Ksr; Molecular Biology; Protein Kinase; Protein-Protein Interaction; Raf; Ras-Erk Signaling; Signal Transduction; Structural Biology

$856,800

Implication of CNK in the regulation of RAS/MAPK pathway

SupervisorCIHR2012Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Bergeron-Labrecque, Fanny

Keywords: Cancer; Ksr; Protein Interaction; Raf; Ras/Mapk; Signalisation

$105,000

A systems-level study of the mechanisms leading to RAF dimerization and activation

SupervisorCIHR2012CIHR Fellowship

Principal investigators: Lavoie, Hugo

Keywords: Bioluminescence; Cancer Therapies; Fluorescence; High-Throughput Screening; Molecular Biology; Pharmacology; Protein-Protein Interactions

$90,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Marc Therrien

Research

Latest papers

Latest funding

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

RAS signaling gets granular.

The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.

CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.

Functional characterization of a PROTAC directed against BRAF mutant V600E.

ERK signalling: a master regulator of cell behaviour, life and fate.

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.

Control of MAPK levels in Drosophila

Frequent collaborators

Frank Sicheri

Pierre Thibault

Sylvain Meloche

Trang Hoang

Damien D'Amours

Ivan Topisirovic

Etienne Caron

Ahmed Aman

Anne Marinier

David Uehling

Ian Shrier

Anne-Claude Gingras

Sylvie Mader

Alain Verreault

Claude Perreault

Hubert Labelle

Sylvie Mader

Vincent Archambault

Jean-Yves Masson

Daniel Durocher

Mitsuhiko Ikura

Brian Raught

Guy Sauvageau

Mikko Taipale

Ivan Topisirovic