Vincent Archambault

Research

Drosophila Mitosis Genetics Phosphatase Cell Biology Cell Division Kinase Cancer

Latest papers

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis.
eLife · 2025 · senior author
Studying Mitotic Phosphorylation in Drosophila.
Methods in molecular biology (Clifton, N.J.) · 2025 · senior author

All 15 publications

Latest funding

Deciphering Mitotic Functions of Phosphoprotein Phosphatases in Drosophila
CIHR · 2024 · Nominated PI
$918,000
Live cell imaging platform for the mechanistic analysis of cell differentiation, migration and division
NSERC · 2024 · Co-investigator
$150,000
The 18th Canadian Drosophila Research Conference - CanFly2025
CIHR · 2024 · Co-investigator
$10,000

All 14 grants and awards

15 publications.

01

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

02

Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis.

Li J, Wang X, Jordana L, Bonneil É, Ginestet V, Ahmed M, Bourouh M, Pascariu CM, Schmeing TM, Thibault P, Archambault V

eLife2025Senior author

DOI: 10.7554/elife.104233 PMID: 39964262

03

Studying Mitotic Phosphorylation in Drosophila.

Bonneil É, Larouche M, Emond-Fraser V, Kubiniok P, Pascariu CM, Thibault P, Archambault V

Methods in molecular biology (Clifton, N.J.)2025Senior author

DOI: 10.1007/978-1-0716-4236-8_14 PMID: 39614055

04

PP2A-Tws dephosphorylates Map205, is required for Polo localization to microtubules and promotes cytokinesis in Drosophila.

Guelle M, Emond-Fraser V, Archambault V

Cell division2024Senior author

DOI: 10.1186/s13008-024-00141-x PMID: 39732709

05

Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.

Li J, Jordana L, Mehsen H, Wang X, Archambault V

PLoS biology2024Senior author

DOI: 10.1371/journal.pbio.3002780 PMID: 39186808

06

Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression.

Larouche M, Kachaner D, Wang P, Normandin K, Garrido D, Yao C, Cormier M, Johansen KM, Johansen J, Archambault V

The Journal of cell biology2021Senior author

DOI: 10.1083/jcb.202008145 PMID: 33836042

07

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

Garrido D, Bourouh M, Bonneil É, Thibault P, Swan A, Archambault V

PLoS genetics2020Senior author

DOI: 10.1371/journal.pgen.1009184 PMID: 33137813

08

PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila.

Mehsen H, Boudreau V, Garrido D, Bourouh M, Larouche M, Maddox PS, Swan A, Archambault V

The Journal of cell biology2018Senior author

DOI: 10.1083/jcb.201804018 PMID: 30309980

09

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.

Yao C, Wang C, Li Y, Zavortink M, Archambault V, Girton J, Johansen KM, Johansen J

PloS one2018

DOI: 10.1371/journal.pone.0208022 PMID: 30485354

10

A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key.

Pintard L, Archambault V

Open biology2018Senior author

DOI: 10.1098/rsob.180114 PMID: 30135239

Deciphering Mitotic Functions of Phosphoprotein Phosphatases in Drosophila

Nominated PICIHR2024Project Grant

Principal investigators: Archambault, Vincent

Keywords: Cell Biology; Cell Division; Drosophila; Genetics; Microscopy; Mitosis; Phosphatase; Phosphorylation; Protein Interactions; Proteomics

$918,000

Live cell imaging platform for the mechanistic analysis of cell differentiation, migration and division

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Mader, Sylvie

Keywords: Biosensors; Cell differentiation; Cell division; Cell migration; Fluorescence; Live cell imaging; Morphogensis; Protein expression; Protein stability; Subcellular localization of proteins

$150,000

The 18th Canadian Drosophila Research Conference - CanFly2025

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hipfner, David R

Keywords: Cell Biology; Disease Models; Drosophila; Evolution; Genetics; Genomics; Molecular Biology; Neurobiology; Physiology; Sex Differences

$10,000

Molecular dissection of mitotic kinase functions using chemogenomics

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Archambault, Vincent

$102,000

Tracking collective cell migration by confocal microscopy

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Emery, Gregory

$58,573

Understanding Nuclear Envelope Reformation after Mitosis using Drosophila

Nominated PICIHR2020Project Grant

Principal investigators: Archambault, Vincent

Keywords: Cell Biology; Cell Division; Drosophila; Kinase; Micronuclei; Mitosis; Nuclear Envelope; Phosphatase

$761,175

Understanding the triggers of mitotic exit using Drosophila

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Archambault, Vincent

$32,000

Mechanisms Coordinating Polo Kinase Activity and Localization in Cell Division

Nominated PICIHR2016Project Grant

Principal investigators: Archambault, Vincent

Keywords: Cancer; Cell Division; Chemogenomics; Crispr; Cytokinesis; Drosophila; Genetics; Human Cells; Mitosis; Polo Kinase

$906,525

Cell Cycle Control by the PP2A-B55 Module

Nominated PICIHR2013Operating Grant

Principal investigators: Archambault, Vincent

Keywords: Cancer; Cell Biology; Cell Cycle; Drosophila; Genetics; Kinase; Mitosis; Mitotic Entry; Mitotic Exit; Phosphatase

$662,018

Molecular Dissection of Mitotic Exit

Nominated PICIHR2012Operating Grant - PA: Cancer Research (bridge funding)

Principal investigators: Archambault, Vincent

Keywords: Cancer; Cell Cycle; Drosophila; Genetics; Human Cells; Kinase; Mitosis; Mitotic Exit; Molecular Biology; Phosphatase

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Institut de recherche en immunologie et cancer
Biochimie et médecine moléculaire
Chemistry
Research Institute
Cellular and Molecular Medicine
Lunenfeld-Tanenbaum Research Institute
Lady Davis Institute for Medical Research
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Pierre Thibault

Faculty

3 shared papers, latest 2026

Guy Sauvageau

Institut de recherche en immunologie et cancer

1 shared papers, latest 2026

Ivan Topisirovic

Lady Davis Institute for Medical Research

1 shared papers, latest 2026

Marc Therrien

Faculty

1 shared papers, latest 2026

Anne Marinier

Chemistry

1 shared papers, latest 2026

Brian Raught

Research Institute

1 shared papers, latest 2026

Trang Hoang

Pharmacology

1 shared papers, latest 2026

Damien D'Amours

Cellular and Molecular Medicine

1 shared papers, latest 2026

Ivan Topisirovic

Faculty

1 shared papers, latest 2026

Sylvain Meloche

Institut de recherche en immunologie et cancer

1 shared papers, latest 2026

Frank Sicheri

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2026

Sylvie Mader

Biochimie et médecine moléculaire

1 shared papers, latest 2026

Alain Verreault

Institut de recherche en immunologie et cancer

1 shared papers, latest 2026

Sylvie Mader

Chemical Engineering

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Drosophila Dear Professor Archambault, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Deciphering Mitotic Functions of Phosphoprotein Phosphatases in Drosophila" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]