Faculty profile

Miroslaw Cygler

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Professor EmeritusDepartment of Biochemistry, Microbiology and ImmunologyUniversity of Saskatchewan

Miroslaw Cygler

Professor Emeritus

Department of Biochemistry, Microbiology and Immunology

College of Medicine

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Supervision signals

Emeritus professors are retired and rarely take new students.
11 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CFI), most recently in 2015.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

296

Publications

17,296

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Saskatchewan profile.

Host-Pathogen interactions, Synthesis and degradation of Glycosaminoglycans

Latest papers

Structure and Assembly of the Calcium-Binding Domains of Calpain
2026 · senior author
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
Nature Metabolism · 2025
Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.
Nature communications · 2025

All 296 publications

Latest funding

Toward Cutting Edge Science: Establishing Advanced Micro-beam Capability for Macromolecular Crystallography at the CLS
CFI · 2015 · Principal investigator
$3,483,565
Biomolecular Research Facilities: Supporting Agricultural, Health & Environmental Sciences
CFI · 2012 · Co-investigator
$1,599,798
Equipment for Research in Advanced Protein Structural Biology
CFI · 2011 · Principal investigator
$399,997

All 3 grants and awards

From the 150 most recent of 296 publications.

Structure and Assembly of the Calcium-Binding Domains of Calpain

Sthanam V. L. Narayana, John S. Elce, Debasish Chattopadhyay, Guang-da Lin, Mike Carson, Helen Blanchard, Pawel Grochulski, Mirosław Cygler

2026Senior author

DOI: 10.1201/9781003760368-4

d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1

Joséphine Zangari, Oliver Stehling, Sven‐Andreas Freibert, Kaushik Bhattacharya, Florian Rouaud, Véronique Serre‐Beinier, Kinsey Maundrell, Sylvie Montessuit, Sabrina Ferré, Evangelia Vartholomaiou, Vinzent Schulz, Karim Zuhra, Víctor González‐Ruiz, Sahra Hanschke, Takashi Tsukamoto, Michaël Cerezo, Csaba Szabó, Serge L. Rudaz, Michal T. Boniecki, Mirosław Cygler, Roland Lill, Jean‐Claude Martinou

Nature Metabolism202514 citationsOpen Access

DOI: 10.1038/s42255-025-01339-1 PMID: 40797101

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

Zhu H, Sydor AM, Yan BR, Li R, Boniecki MT, Lyons C, Cygler M, Muise AM, Maxson ME, Grinstein S, Raught B, Brumell JH

Nature communications20258 citationsOpen Access

DOI: 10.1038/s41467-025-57453-x PMID: 40057496

The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations

Laure Ségurel, Thirumalai Selvi Ulaganathan, Sophie Mathieu, Mélanie Loiodice, Laurent Poulet, Sophie Drouillard, Mirosław Cygler, William Helbert

PLoS ONE20252 citationsOpen Access

DOI: 10.1371/journal.pone.0329457 PMID: 40748897

Structural Changes at the Zinc Active Site of ACE2 on Binding the SARS-CoV-2 Spike Protein Receptor Binding Domain

Natalia V. Dolgova, Muhammad Qureshi, Matthew J. Latimer, Andrey M. Grishin, Mirosław Cygler, Linda Vogt, Julien J. H. Cotelesage, Dimosthenis Sokaras, Thomas Kröll, Ingrid J. Pickering, Graham Neil George

Inorganic Chemistry20252 citations

DOI: 10.1021/acs.inorgchem.4c04974 PMID: 39962897

The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin

Monica Rolando, Ivy Yeuk Wah Chung, Caishuang Xu, Laura Gómez-Valero, Patrick England, Mirosław Cygler, Carmen Buchrieser

mBio202316 citationsOpen Access

DOI: 10.1128/mbio.01655-23 PMID: 37795993

D-cysteine inhibits iron-sulfur cluster assembly and impairs tumour growth

Jean‐Claude Martinou, Joséphine Zangari, Oliver Stehling, Sven‐Andreas Freibert, Florian Rouaud, Véronique Serre‐Beinier, Kinsey Maundrell, Sylvie Montessuit, Sabrina Ferré, Evangelia Vartholomaiou, Vinzent Schulz, Karim Zuhra, Víctor González‐Ruiz, Sarah Hanschke, Takashi Tsukamoto, Csaba Szabó, Serge L. Rudaz, Michal T. Boniecki, Mirosław Cygler, Roland Lill

Research Square20231 citationsOpen Access

DOI: 10.21203/rs.3.rs-3355970/v1

The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations

Laure Ségurel, Thirumalai Selvi Ulaganathan, Sophie Mathieu, Mélanie Touvrey, Laurent Poulet, Sophie Drouillard, Mirosław Cygler, William Helbert

bioRxiv (Cold Spring Harbor Laboratory)20231 citationsOpen Access

DOI: 10.1101/2023.03.30.534863

Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen.

Grishin AM, Dolgova NV, Landreth S, Fisette O, Pickering IJ, George GN, Falzarano D, Cygler M

Journal of molecular biology202267 citationsSenior authorOpen Access

DOI: 10.1016/j.jmb.2021.167357 PMID: 34780781

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli

Georgina L. Pollock, Andrey M. Grishin, Cristina Giogha, Jiyao Gan, Clare V. L. Oates, Paul J. McMillan, Isabella Gaeta, Matthew J. Tyska, Jaclyn S. Pearson, Nichollas E. Scott, Mirosław Cygler, Elizabeth Louise Hartland

Proceedings of the National Academy of Sciences202211 citationsOpen Access

DOI: 10.1073/pnas.2204332119 PMID: 35976880

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Miroslaw Cygler

Research

Latest papers

Latest funding

Structure and Assembly of the Calcium-Binding Domains of Calpain

d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations

Structural Changes at the Zinc Active Site of ACE2 on Binding the SARS-CoV-2 Spike Protein Receptor Binding Domain

The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin

D-cysteine inhibits iron-sulfur cluster assembly and impairs tumour growth

The porphyran degradation system is complete, phylogenetically and geographically diverse across the gut microbiota of East Asian populations

Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen.

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli

Toward Cutting Edge Science: Establishing Advanced Micro-beam Capability for Macromolecular Crystallography at the CLS

Biomolecular Research Facilities: Supporting Agricultural, Health & Environmental Sciences

Equipment for Research in Advanced Protein Structural Biology

Frequent collaborators

Mirek Cygler

Rong Shi

Kalle Gehring

David Thomas

Zongchao Jia

Michael Sacher

John Bergeron

Jean-François Trempe

Alla Gagarinova

Mohan Babu

Deborah Anderson

Gerard Wright

Sergio Grinstein

John Brumell

Graham George

Ingrid Pickering

Gary Shaw

Brian Shilton

Malcolm Whiteway

David Rose

Brian Raught