Faculty profile

E Michelakis

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ProfessorMedicine DeptUniversity of Alberta

E Michelakis

Professor

Medicine Dept

Faculty of Medicine & Dentistry

University of Alberta

Edmonton, Alberta, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
37 publications in the last five years, latest in 2026.
Senior (last) author on 15 recent papers, a sign of leading a research group.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

280

Publications

23,473

Citations

Collaborators

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Alberta profile.

Latest papers

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.
Science translational medicine · 2026
Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.
Nature communications · 2026 · senior author
Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.
Circulation · 2026 · senior author

All 280 publications

From the 150 most recent of 280 publications.

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Lorenzana-Carrillo MA, Tejay S, Huang G, Nanoa J, Zhao YY, Wagg C, Eaton F, Mendiola Pla M, Bowles DE, Kinnaird A, Michelakis ED, Tabatabaei Dakhili SA, Ussher JR, Sutendra G

Science translational medicine20262 citations

DOI: 10.1126/scitranslmed.adz7727 PMID: 41984928

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Piao J, Zhang Y, Zhao YY, Hanington P, Hambrook J, Liu Y, Ussher JR, Tabatabaei Dakhili SA, Sutendra G, Michelakis ED

Nature communications20261 citationsSenior authorOpen Access

DOI: 10.1038/s41467-026-74208-4 PMID: 42271149

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Zhang Y, Bonnet S, Provencher S, Piao J, Haromy A, Liu Y, Zhao YY, Breuils-Bonnet S, Lemay SE, Bowles DE, Mendiola Pla M, Sutendra G, Michelakis ED

Circulation20261 citationsSenior authorOpen Access

DOI: 10.1161/circulationaha.125.078674 PMID: 41797703

An inducer of snail hibernation causes quiescence and hibernation-like cardioprotection, through metabolic rewiring and autophagy, in mice hearts

Jiyuan Piao, Yongneng Zhang, Yuanyuan Zhao, Patrick C. Hanington, Jacob R. Hambrook, Yongsheng Liu, John Ussher, Amir Tabatabaei Dakhili, Gopinath Sutendra, Evangelos D. Michelakis

bioRxiv (Cold Spring Harbor Laboratory)2026Senior authorOpen Access

DOI: 10.64898/2026.01.08.698452

Pharmacologic Targeting of ZNF281 Suppresses Metastatic Prostate Cancer Beyond Androgen Receptor Dependence

Guocheng Huang, Maria Areli Lorenzana Carrillo, Hua Chen, Runtai Chen, Saba Abbasi Dezfouli, Joseph Nanoa, Dania Rimawi, Alois Haromy, Yuanyuan Zhao, Rohan Mittal, John Lewis, John Ussher, Evangelos D. Michelakis, Ronald Moore, Amir Tabatabaei Dakhili, Gopinath Sutendra, Adam Kinnaird

bioRxiv (Cold Spring Harbor Laboratory)2026Open Access

DOI: 10.64898/2026.09.03.749302

Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial

Georgios Tavoulareas, Olga Kontakou-Zoniou, Antonakos Nikolaos, Elisavet Tasouli, George Adamis, Nikolaos Kakavoulis, Evangelos D. Michelakis, Ilias Skopelitis, Konstantina Dakou, Christos Psarrakis, Panagiotis Koufargyris, Myrto Astriti, Styliani Sympardi, Evangelos J. Giamarellos-Bourboulis

The Lancet Regional Health - Europe20258 citationsOpen Access

DOI: 10.1016/j.lanepe.2025.101573 PMID: 41552367

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation.

Chen R, Tabatabaei Dakhili SA, Gerulskis R, Zhao YY, Lockhart S, Tonoyan L, Siraki AG, Huang G, Kinnaird A, Freed DH, Minteer SD, Michelakis ED, Ussher JR, Sutendra G

The Journal of biological chemistry20258 citationsOpen Access

DOI: 10.1016/j.jbc.2025.110555 PMID: 40752580

Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.

Darwesh AM, Fang L, Altamimi TR, Jamieson KL, Bassiouni W, Valencia R, Huang A, Wang F, Zhang H, Ahmed M, Gopal K, Zhang Y, Michelakis ED, Ussher JR, Edin ML, Zeldin DC, Barakat K, Oudit GY, Kassiri Z, Lopaschuk GD, Seubert JM

Cardiovascular research20257 citationsOpen Access

DOI: 10.1093/cvr/cvae252 PMID: 39658136

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Tejay S, Lorenzana-Carrillo MA, Huang G, Tabatabaei Dakhili SA, Zhao Y-, Eaton F, Mendiola Pla M, Bowles DE, Kinnaird A, Paterson DI, Pituskin E, Ussher JR, Michelakis ED, Sutendra G

Nature communications20253 citationsOpen Access

DOI: 10.1038/s41467-025-62172-4 PMID: 40715150

Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI.

Huang G, Albers P, Mookerji N, Pfanner T, Hui A, Mittal R, Broomfield S, Dean L, St Martin B, Jacobsen NE, Evans H, Gao Y, Hung R, Abele J, Dromparis P, Lima JF, Bismar TA, Michelakis E, Sutendra G, Wuest F, Tu W, Adam BA, Fung C, Ghosh S, Tamm A, Kinnaird A, Next Generation Trial Investigators

European journal of nuclear medicine and molecular imaging20252 citationsOpen Access

DOI: 10.1007/s00259-024-07021-0 PMID: 39725694

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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E Michelakis

Research

Latest papers

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

An inducer of snail hibernation causes quiescence and hibernation-like cardioprotection, through metabolic rewiring and autophagy, in mice hearts

Pharmacologic Targeting of ZNF281 Suppresses Metastatic Prostate Cancer Beyond Androgen Receptor Dependence

Efficacy of anakinra in reducing progression to organ dysfunction in patients with pneumonia (INSPIRE): a randomised, double-blind, placebo-controlled, phase IIa trial

Cysteine oxidation of a redox hub within complex I can facilitate electron transport chain supercomplex formation.

Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3.

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Three-dimensional spatial localization and volume estimation of prostate tumors using 18F-PSMA-1007 PET/CT versus multiparametric MRI.

Frequent collaborators

Evangelos Michelakis

Gopinath Sutendra

Stephen Archer

Sébastien Bonnet

Roxane Paulin

Jason Dyck

Steeve Provencher

Michael McMurtry

Bernard Thébaud

Adam Kinnaird

Darren Freed

John Ussher

Ian Paterson

Gary Lopaschuk

Francois Potus

Jayan Nagendran

Gavin Oudit

Richard Thompson

Frank Wuest

Spencer Proctor

Duncan Stewart

Shawn Winer

Dan Winer

Jocelyn Dupuis