Renée Douville, University of Manitoba

Research

Read how they describe their research on their University of Manitoba profile.

Bioinformatics Endogenous retrovirus (ERV)Human genome Insertional polymorphism Long terminal repeat (LTR)Molecular biology Provirus Transcription factors

Latest papers

Implications of virus-induced stress granules in tauopathies
Figshare · 2026 · senior author
ERVK activity in CD8+ T cell immune cell compartment in patients with ALS
Journal of Neuroinflammation · 2026 · senior author
Additional file 1 of Implications of virus-induced stress granules in tauopathies
Figshare · 2026 · senior author

All 44 publications

Latest funding

Subcellular Protein Assembly (SPA) Platforms for Investigating Mechanisms of Neurological Disease.
CFI · 2024 · Principal investigator
$344,169
DNA damage driven motor disturbance in ALS: An ERVK integrase transgenic mouse model
BRAIN · 2023 · Principal investigator
$124,900
RetroExplorer: An Interactive Database of Endogenous Retroviruses in the Human Genome
NSERC · 2016 · Principal investigator
$279,000

All 5 grants and awards

44 publications.

01

Implications of virus-induced stress granules in tauopathies

Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville

Figshare2026Senior authorOpen Access

DOI: 10.6084/m9.figshare.c.8305211

02

ERVK activity in CD8+ T cell immune cell compartment in patients with ALS

Snigdda Sharma, Claudia Cortés-Pérez, Sasha Bird, Domenico Di Curzio, Alex Vandenakker, Kerri Schellenberg, Renée N. Douville

Journal of Neuroinflammation2026Senior authorOpen Access

DOI: 10.1186/s12974-026-03871-7 PMID: 42177561

03

Additional file 1 of Implications of virus-induced stress granules in tauopathies

Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville

Figshare2026Senior authorOpen Access

DOI: 10.6084/m9.figshare.31321508

04

Implications of virus-induced stress granules in tauopathies

Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville

Translational Neurodegeneration2026Senior authorOpen Access

DOI: 10.1186/s40035-026-00538-4 PMID: 41673769

05

Implications of virus-induced stress granules in tauopathies

Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville

Figshare2026Senior authorOpen Access

DOI: 10.6084/m9.figshare.c.8305211.v1

06

Additional file 1 of Implications of virus-induced stress granules in tauopathies

Snigdda Sharma, Alex Vandenakker, Claudia Mariana Cortes-Pérez, Sarah Milne, Renée N. Douville

Figshare2026Senior authorOpen Access

DOI: 10.6084/m9.figshare.31321508.v1

07

AI is a viable alternative to high throughput screening: a 318-target study

Wallach I, Bernard D, Nguyen K, Ho G, Morrison A, Stecula A, Rosnik A, O’Sullivan AM, Davtyan A, Samudio B

Scientific Reports2024147 citationsOpen Access

DOI: 10.1038/s41598-024-54655-z

08

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections.

Jacob S, Kapadia R, Soule T, Luo H, Schellenberg KL, Douville RN, Pfeffer G

Frontiers in neurology202221 citationsOpen Access

DOI: 10.3389/fneur.2022.914411 PMID: 35812094

09

Drosophila as a Model for Human Viral Neuroinfections.

Benoit I, Di Curzio D, Civetta A, Douville RN

Cells20229 citationsSenior authorOpen Access

DOI: 10.3390/cells11172685 PMID: 36078091

10

Predicted cellular interactors of the endogenous retrovirus-K protease enzyme

Samuel Narvey, Alex Vandenakker, Megan Rempel, Renée N. Douville

Frontiers in Virology20221 citationsSenior authorOpen Access

DOI: 10.3389/fviro.2022.972156

Subcellular Protein Assembly (SPA) Platforms for Investigating Mechanisms of Neurological Disease.

Principal investigatorCFI2024John R. Evans Leaders Fund: John R. Evans Leaders Fund – Funding for research infrastructure

Principal investigators: Douville, Renée

Keywords: Subcellular protein assemblies, GPCRs, Proteinopathy, Drosophila and murine models of neurodevelopment, neuropsychiatry and neurodegeneration, Behaviour Kinetics of protein assemblies, laser microdissection, behavioural analysis.

$344,169

DNA damage driven motor disturbance in ALS: An ERVK integrase transgenic mouse model

Principal investigatorBRAIN2023ALS Canada - Brain Canada Discovery Grants

Principal investigators: Douville, Renée

Keywords: ALS

$124,900

RetroExplorer: An Interactive Database of Endogenous Retroviruses in the Human Genome

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Douville, Renée

Keywords: endogenous retrovirus (erv); bioinformatics; human genome; long terminal repeat (ltr); provirus; insertional polymorphism; transcription factors; molecular biology; viral proteins; web-accessible database

$279,000

Re-activation of human endogenous retrovirus-K in Amyotrophic Lateral Sclerosis: A consequence of genetic mutations in TDP43 and Optineurin.

SupervisorCIHR2013Master's Award: Canada Graduate Scholarships

Principal investigators: Manghera, Mamneet

Keywords: Amyotrophic Lateral Sclerosis; Confocal Microscopy; Functional Polymorphisms; Human Endogenous Retrovirus-K; Inflammatory Disease; Inflammatory Transcription Factors; Innate Immunity; Interferon Response Factors; Neurovirology; Nuclear Factor-Kappa B Signaling

$17,500

Confocal Imaging the Reactivation of Endogenous Retroviruses in Neurological Disease

Principal investigatorCFI2012John R. Evans Leaders Fund: John R. Evans Leaders Fund – Funding for research infrastructure

Principal investigators: Douville, Renee

Keywords: Confocal microscope, Human Endogenous Retrovirus, Virology, Neurons, Innate Immune Response, Human Brain and Spinal Cord Tissue, Neuropathology, Neurological Disease, Amyotrophic Lateral Sclerosis (ALS)

$150,064

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Andrew Freywald and Franco Vizeacoumar: 117 shared papers
Kent HayGlass and Anita Kozyrskyj: 22 shared papers
Jason Maynes and John Coles: 22 shared papers
Deborah Anderson and Franco Vizeacoumar: 13 shared papers
Gerald Pfeffer and Kerri Schellenberg: 10 shared papers
Kent HayGlass and Renée Douville: 7 shared papers
Deborah Anderson and Andrew Freywald: 7 shared papers
Ruey-Chyi Su and Joshua Kimani: 6 shared papers
Kent HayGlass and Peter Nickerson: 5 shared papers
Kent HayGlass and Ruey-Chyi Su: 5 shared papers
Andrew Freywald and Kirk McManus: 3 shared papers
Anita Kozyrskyj and Ruey-Chyi Su: 3 shared papers
Ruey-Chyi Su and Renée Douville: 3 shared papers
Franco Vizeacoumar and Kirk McManus: 3 shared papers
Franco Vizeacoumar and Gary Eitzen: 3 shared papers
Jeffrey Dickhout and Deborah Anderson: 2 shared papers
Jeffrey Dickhout and Leah Cowen: 2 shared papers
Jeffrey Dickhout and Andrew Freywald: 2 shared papers
Jeffrey Dickhout and Gergely Lukacs: 2 shared papers
Jeffrey Dickhout and Jason Maynes: 2 shared papers
Jeffrey Dickhout and John Pascal: 2 shared papers
Jeffrey Dickhout and John Coles: 2 shared papers
Jeffrey Dickhout and Kirk McManus: 2 shared papers
Jeffrey Dickhout and Gary Eitzen: 2 shared papers
Jeffrey Dickhout and Michael Mowat: 2 shared papers
Jeffrey Dickhout and Daniel Chen: 2 shared papers
Kent HayGlass and Kevin Coombs: 2 shared papers
Deborah Anderson and Leah Cowen: 2 shared papers
Deborah Anderson and Gergely Lukacs: 2 shared papers
Deborah Anderson and Jason Maynes: 2 shared papers
Deborah Anderson and John Pascal: 2 shared papers
Deborah Anderson and John Coles: 2 shared papers
Deborah Anderson and Gary Eitzen: 2 shared papers
Deborah Anderson and Michael Mowat: 2 shared papers
Deborah Anderson and Daniel Chen: 2 shared papers
Leah Cowen and Andrew Freywald: 2 shared papers
Leah Cowen and Gergely Lukacs: 2 shared papers
Leah Cowen and John Pascal: 2 shared papers
Leah Cowen and Michael Mowat: 2 shared papers
Leah Cowen and Daniel Chen: 2 shared papers
Rongtuan Lin and Renée Douville: 2 shared papers
Kevin Coombs and Renée Douville: 2 shared papers
Anita Kozyrskyj and Renée Douville: 2 shared papers
Joshua Kimani and Renée Douville: 2 shared papers
Kerri Schellenberg and Renée Douville: 2 shared papers
Jeffrey Dickhout and Renée Douville: 1 shared paper
Deborah Anderson and Renée Douville: 1 shared paper
Honglin Luo and Kevin Coombs: 1 shared paper
Honglin Luo and Gerald Pfeffer: 1 shared paper
Honglin Luo and Kerri Schellenberg: 1 shared paper
Honglin Luo and Renée Douville: 1 shared paper
Leah Cowen and Renée Douville: 1 shared paper
Peter Nickerson and Kevin Coombs: 1 shared paper
Peter Nickerson and Renée Douville: 1 shared paper
Andrew Freywald and Renée Douville: 1 shared paper
Gergely Lukacs and Renée Douville: 1 shared paper
Jason Maynes and Renée Douville: 1 shared paper
John Pascal and Renée Douville: 1 shared paper
Franco Vizeacoumar and Renée Douville: 1 shared paper
John Coles and Renée Douville: 1 shared paper
Kirk McManus and Renée Douville: 1 shared paper
Gerald Pfeffer and Renée Douville: 1 shared paper
Gary Eitzen and Renée Douville: 1 shared paper
Alberto Civetta and Renée Douville: 1 shared paper
Renée Douville and Michael Mowat: 1 shared paper
Renée Douville and Daniel Chen: 1 shared paper

Department of Medicine
Department of Oncology
Pediatrics Dept
Department of Medical Microbiology and Infectious Diseases
Department of Clinical Neurosciences
Biology
Pathology and Laboratory Medicine
Other

Applying for

Paper to mentionMention their CFI grant from 2024

Subject: Prospective PhD student: Bioinformatics Dear Professor Douville, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Implications of virus-induced stress granules in tauopathies" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CFI-funded project "Subcellular Protein Assembly (SPA) Platforms for Investigating Mechanisms of Neurological Disease." (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]