Faculty profile

Jack Antel

ResearcherBiomedical EngineeringMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Jack Antel

Researcher

Biomedical Engineering

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
17 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2013.
Supervised 1 trainee who won CIHR awards, most recently in 2008.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Bdnf/Igf-1 Or Nt-3 Delivery Biomedical Engineering 1102 Biomedical Materials 1902 Biomedical Technology 1901 Chitosan Guanosine 5'-Diphosphate (Gdp)-Crosslinked Sponge Contused Spinal Cord In A Mouse Model Injectable Sponge Life Sciences 1201

Latest papers

A novel small molecule remyelination therapy for multiple sclerosis.
npj drug discovery · 2026
Toward a Neuroimaging Consensus for the Work-up of Adult Genetic Leukoencephalopathies on Behalf of the White Matter Rounds Network: State of Practice.
AJNR. American journal of neuroradiology · 2026
In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.
Science translational medicine · 2026

All 75 publications

Latest funding

Could mitotic senescence in NG2-glia explain the remyelination deficit in MS?
CIHR · 2020 · Co-investigator
$837,675
Could mitotic exhaustion of NG2-glia explain the remyelination deficit in MS?
CIHR · 2019 · Co-investigator
$100,000
Rapidly-Gelling, Guanosine 5' Diphosphate-Crosslinked Injectable Chitosan Sponges to Promote Oligodendrocyte Progenitor Cells' Differentiation Post-Spinal Cord Injuries
NSERC · 2014 · Co-investigator
$277,441

All 8 grants and awards

75 publications.

A novel small molecule remyelination therapy for multiple sclerosis.

Yang Y, Bai B, Knutsen LJS, Hamlyn RJ, Cui QL, Antel J, Macklin W, Medicetty S, Trapp BD

npj drug discovery2026

DOI: 10.1038/s44386-026-00060-7 PMID: 42493540

Toward a Neuroimaging Consensus for the Work-up of Adult Genetic Leukoencephalopathies on Behalf of the White Matter Rounds Network: State of Practice.

Wong AD, Airas L, Alvarez E, Antel J, Araujo D, Bernard G, Boudjani H, Brais B, Cocozza S, Corboy JR, Fadda G, Imitola J, Lacasse MC, Longbrake EE, Macaron G, Narayanan S, Orthmann-Murphy J, Ortiz J, Shor N, Uggetti C, Venkateswaran S, Wilson N, Miller E, La Piana R, White Matter (WM) Rounds Network

AJNR. American journal of neuroradiology2026

DOI: 10.3174/ajnr.a9127 PMID: 41371978

In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.

Gacem N, Bezukladova S, Windener F, Karam T, Ottoboni L, Brambilla E, Ruffini F, Soman K, Garcia-Diaz B, Levy MJF, Cui QL, Formato A, Deboux C, Chazot J, Panic R, Albrecht S, Yilmaz EN, González RG, Eberini I, Olla S, Bresciani A, Goebels N, Zipp F, Agresti C, Antel J, Evercooren AB, Kuhlmann T, Baranzini SE, Panina-Bordignon P, Nait-Oumesmar B, Martino G

Science translational medicine2026

DOI: 10.1126/scitranslmed.ads0633 PMID: 41564155

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS.

Windener F, Grewing L, Thomas C, Dorion MF, Otteken M, Kular L, Jagodic M, Antel J, Albrecht S, Kuhlmann T

Acta neuropathologica2024

DOI: 10.1007/s00401-024-02733-x PMID: 38722375

Identity and nature of neural stem cells in the adult human subventricular zone.

Baig S, Nadaf J, Allache R, Le PU, Luo M, Djedid A, Nkili-Meyong A, Safisamghabadi M, Prat A, Antel J, Guiot MC, Petrecca K

iScience2024

DOI: 10.1016/j.isci.2024.109342 PMID: 38495819

ALCAM on human oligodendrocytes mediates CD4 T cell adhesion.

Jamann H, Desu HL, Cui QL, Halaweh A, Tastet O, Klement W, Zandee S, Pernin F, Mamane VH, Ouédraogo O, Daigneault A, Sidibé H, Millette F, Peelen E, Dhaeze T, Hoornaert C, Rébillard RM, Thai K, Grasmuck C, Vande Velde C, Prat A, Arbour N, Stratton JA, Antel J, Larochelle C

Brain : a journal of neurology2024

DOI: 10.1093/brain/awad286 PMID: 37640028

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion MF, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR

Nature communications2023

DOI: 10.1038/s41467-023-40937-z PMID: 37640701

Clinical course, imaging, and pathological features of 45 adult and pediatric cases of myelin oligodendrocyte glycoprotein antibody-associated disease.

Boudjani H, Fadda G, Dufort G, Antel J, Giacomini P, Levesque-Roy M, Oskoui M, Duquette P, Prat A, Girard M, Rebillard RM, Meijer I, Pinchefsky E, Nguyen CE, Rossignol E, Rouleau J, Blanchard O, Khairallah N, Beauchemin P, Trudelle AM, Lapointe E, Saveriano A, Larochelle C

Multiple sclerosis and related disorders2023

DOI: 10.1016/j.msard.2023.104787 PMID: 37320939

Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing.

Yaqubi M, Groh AMR, Dorion MF, Afanasiev E, Luo JXX, Hashemi H, Sinha S, Kieran NW, Blain M, Cui QL, Biernaskie J, Srour M, Dudley R, Hall JA, Sonnen JA, Arbour N, Prat A, Stratton JA, Antel J, Healy LM

Journal of neuroinflammation2023

DOI: 10.1186/s12974-023-02809-7 PMID: 37254100

Inflammation in multiple sclerosis: consequences for remyelination and disease progression.

Klotz L, Antel J, Kuhlmann T

Nature reviews. Neurology2023

DOI: 10.1038/s41582-023-00801-6 PMID: 37059811

Could mitotic senescence in NG2-glia explain the remyelination deficit in MS?

Co-investigatorCIHR2020Project Grant

Principal investigators: Kokoeva, Maia

Keywords: Demyelination; Multiple Sclerosis; Ng2-Glia; Oligodendrocyte Precursor Cells (Opcs); Remyelination

$837,675

Could mitotic exhaustion of NG2-glia explain the remyelination deficit in MS?

Co-investigatorCIHR2019Project Grant - PA: Neurosciences, Mental Health and Addiction

Principal investigators: Kokoeva, Maia

Keywords: Demyelination; Multiple Sclerosis; Myelin; Ng2-Glia; Oligodendrocyte Precursor Cells (Opcs); Remyelination

$100,000

Rapidly-Gelling, Guanosine 5' Diphosphate-Crosslinked Injectable Chitosan Sponges to Promote Oligodendrocyte Progenitor Cells' Differentiation Post-Spinal Cord Injuries

Co-investigatorNSERC2014Collaborative Health Research Projects

Principal investigators: Tabrizian, Maryam

$277,441

Rapidly-Gelling, Guanosine 5' Diphosphate-Crosslinked Injectable Chitosan Sponges to Promote Oligodendrocyte Progenitor Cells' Differentiation Post-Spinal Cord Injuries

Principal investigatorCIHR2013Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Tabrizian, Maryam; Antel, Jack P

Keywords: Bdnf/Igf-1 Or Nt-3 Delivery; Biomedical Engineering 1102; Biomedical Materials 1902; Biomedical Technology 1901; Chitosan Guanosine 5'-Diphosphate (Gdp)-Crosslinked Sponge; Contused Spinal Cord In A Mouse Model; Injectable Sponge; Life Sciences 1201; Rat & Human Oligodendrocyte Progenitor Cells Differentiation; Remyelination Post-Spinal Cord Injury

$277,440

The Canadian Atherosclerosis Inflammation Research Initiative (CAIRI), A novel Trans-disciplinary team approach for the Evaluation of the Immune Risk Phenotype as the underlying shared mechanism of accelerated cardiovascular pathology in chronic inflammatory diseases.

Co-investigatorCIHR2012Team Grant: Health Challenges in Chronic Inflammation Initiative (LOI)

Principal investigators: Tsoukas, Christos M

Keywords: Carotid Magnetic Resonance Imaging; Cd4+Cd28-; Common Variable Immune Deficiency; Cytomegalovirus; Human Immunodeficiency Virus; Immune Risk Phenotype; Immunopathology Of Atherosclerosis; Multi-Parametric Flow Cytometry; Multiple Sclerosis; Systemic Lupus Erythematosus

$15,600

Effects of S1P receptor directed pharmaceutical agents on central nervous system myelination

Nominated PICIHR2010Operating Grant: Industry-partnered Collaborative Research - Rx&D partner

Principal investigators: Antel, Jack P

Keywords: Central Nervous System; Multiple Sclerosis; Myelin; Oligodendrocytes; S1p Receptors

$178,125

The role of netrin in regulating immune cell passage into the brain and blood brain barrier function.

SupervisorCIHR2008Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Podjaski, Cornelia

Keywords: Adhesion; Blood Brain Barrier; Boyden Chamber Assay; Chemoattraction /-Repulsion; Immune Cells; Multiple Sclerosis; Netrin; Netrin Receptors; Transendothelial Migration; Transendothelial Permeability

$105,000

CIHR Integrated Training Program in Basic and Clinical Aspects of Neuroinflammation

Co-investigatorCIHR2008Training Grant

Principal investigators: David, Samuel

Keywords: Cns - Immune Interactions; Cns Inflammation; Multidisciplinary; Multiple Sclerosis; Spinal Cord Injury

$1,950,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jack Antel

Research

Latest papers

Latest funding

A novel small molecule remyelination therapy for multiple sclerosis.

Toward a Neuroimaging Consensus for the Work-up of Adult Genetic Leukoencephalopathies on Behalf of the White Matter Rounds Network: State of Practice.

In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS.

Identity and nature of neural stem cells in the adult human subventricular zone.

ALCAM on human oligodendrocytes mediates CD4 T cell adhesion.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.

Clinical course, imaging, and pathological features of 45 adult and pediatric cases of myelin oligodendrocyte glycoprotein antibody-associated disease.

Analysis of the microglia transcriptome across the human lifespan using single cell RNA sequencing.

Inflammation in multiple sclerosis: consequences for remyelination and disease progression.

Could mitotic senescence in NG2-glia explain the remyelination deficit in MS?

Could mitotic exhaustion of NG2-glia explain the remyelination deficit in MS?

Rapidly-Gelling, Guanosine 5' Diphosphate-Crosslinked Injectable Chitosan Sponges to Promote Oligodendrocyte Progenitor Cells' Differentiation Post-Spinal Cord Injuries

Rapidly-Gelling, Guanosine 5' Diphosphate-Crosslinked Injectable Chitosan Sponges to Promote Oligodendrocyte Progenitor Cells' Differentiation Post-Spinal Cord Injuries

The Canadian Atherosclerosis Inflammation Research Initiative (CAIRI), A novel Trans-disciplinary team approach for the Evaluation of the Immune Risk Phenotype as the underlying shared mechanism of accelerated cardiovascular pathology in chronic inflammatory diseases.

Effects of S1P receptor directed pharmaceutical agents on central nervous system myelination

The role of netrin in regulating immune cell passage into the brain and blood brain barrier function.

CIHR Integrated Training Program in Basic and Clinical Aspects of Neuroinflammation

Frequent collaborators

Amit Bar-Or

Alexandre Prat

Nathalie Arbour

Catherine Larochelle

Kevin Petrecca

Kevin Petrecca

Bratislav Misic

Giulia Fadda

Guillaume Bourque

Bernard Brais

Dusica Maysinger

Roberta La Piana

Elana Pinchefsky

David Langlais

Myriam Srour

Pierre Duquette

Roy Dudley

Myriam Srour

Claudia Martinez-Rios

Nagwa Wilson

Subburaj Ilangumaran

Elsa Rossignol

Christine Vande Velde

Nicolas Bisson

Karen Mossman

Mark Lathrop

Douglas Arnold

Chen Liang

Samuel David

Philippe Gros

Jennifer Gommerman