Faculty profile

Michel Grandbois

ResearcherPharmacologie-PhysiologieUniversité de Sherbrooke

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Sherbrooke directory, so their courses may be missing. Find their university profile.

Michel Grandbois

Researcher

Pharmacologie-Physiologie

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 8 research grants (7 NSERC, 1 CIHR), most recently in 2020.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Atomic force microscopy Cardiomyocyte contraction Force spectroscopy Protein glycation Sarcomere Single molecule experiments Super-resolution microscopy Titin

Latest papers

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.
Journal of medicinal chemistry · 2026
A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.
Acta pharmaceutica Sinica. B · 2026
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.
Pharmacological research · 2025

All 48 publications

Latest funding

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates
NSERC · 2025 · Co-investigator
$150,000
Macrocyclic Inhibitors of the SARS-CoV-2 / ACE-2 Interaction in COVID-19
NSERC · 2020 · Principal investigator
$50,000
Peptide Diversity Generation Apparatus to Elucidate Cell-Molecules Interactions
NSERC · 2019 · Co-investigator
$149,980

All 14 grants and awards

48 publications.

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Ferková S, Fayolle A, Boisvert O, Froehlich U, Nepveu-Traversy MÉ, Lavigne P, Grandbois M, Sarret P, Boudreault PL

Journal of medicinal chemistry2026

DOI: 10.1021/acs.jmedchem.5c03450 PMID: 42289940

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Brouillette RL, Lussier F, Breault É, Meneboo N, Hassanzadeh M, Tremblay V, Chartier M, Midavaine É, Ulrich L, Côté J, Blais V, Mona CE, Longpré JM, Grandbois M, Boudreault PL, Audet M, Besserer-Offroy É, Sarret P

Acta pharmaceutica Sinica. B2026

DOI: 10.1016/j.apsb.2025.12.043 PMID: 42039273

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

Brouillette RL, Mona CE, Desgagné M, Hassanzedeh M, Breault É, Lussier F, Belleville K, Longpré JM, Grandbois M, Boudreault PL, Besserer-Offroy É, Sarret P

Pharmacological research2025

DOI: 10.1016/j.phrs.2025.107597 PMID: 39800176

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Ferková S, Froehlich U, Nepveu-Traversy MÉ, Murza A, Azad T, Grandbois M, Sarret P, Lavigne P, Boudreault PL

International journal of molecular sciences2023

DOI: 10.3390/ijms25010166 PMID: 38203338

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

L'Exact M, Comeau C, Bourhis A, Boisvert O, Fröhlich U, Létourneau D, Marsault É, Lavigne P, Grandbois M, Boudreault PL

Biochimica et biophysica acta. Biomembranes2023

DOI: 10.1016/j.bbamem.2023.184196 PMID: 37400050

Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.

Schüler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF

Frontiers in cell and developmental biology2022

DOI: 10.3389/fcell.2022.1056523 PMID: 36523505

Surface micropatterning for the formation of an in vitro functional endothelial model for cell-based biosensors.

Khadir Z, Schmidt V, Chabot K, Bryche JF, Froehlich U, Moreau J, Canva M, Charette P, Grandbois M

Biosensors & bioelectronics2022Senior author

DOI: 10.1016/j.bios.2022.114481 PMID: 35779408

Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.

Comeau C, Ries B, Stadelmann T, Tremblay J, Poulet S, Fröhlich U, Côté J, Boudreault PL, Derbali RM, Sarret P, Grandbois M, Leclair G, Riniker S, Marsault É

Journal of medicinal chemistry2021

DOI: 10.1021/acs.jmedchem.0c02036 PMID: 33750117

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.

Brouillette RL, Besserer-Offroy É, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P

Pharmacological research2020

DOI: 10.1016/j.phrs.2020.104750 PMID: 32151680

Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben.

Awwad F, Bertrand G, Grandbois M, Beaudoin N

BMC plant biology2019

DOI: 10.1186/s12870-019-2130-2 PMID: 31752698

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates

Co-investigatorNSERC2025Research Tools and Instruments

Principal investigators: Bentzinger, Florian

Keywords: hydrogels; 3d stem cell culture; skeletal muscle tissue; decellularization; extracellular matrix; mechanical testing; elasticity; shear stress; torsion; multiple-well tests

$150,000

Macrocyclic Inhibitors of the SARS-CoV-2 / ACE-2 Interaction in COVID-19

Principal investigatorNSERC2020Alliance Grants

Principal investigators: Grandbois, Michel

$50,000

Peptide Diversity Generation Apparatus to Elucidate Cell-Molecules Interactions

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Marsault, Eric

$149,980

Impact of titin post-translational modifications on muscle contractile function

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Grandbois, Michel

Keywords: Atomic force microscopy; Cardiomyocyte contraction; Force spectroscopy; Protein glycation; Sarcomere; Single molecule experiments; Super-resolution microscopy; Titin

$252,000

Treating chronic pain with pepducins derived from neurotensin receptor type 1 (NTS1)

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Brouillette, Rebecca

Keywords: Allostery; Chronic Pain; Drug Discovery; G Protein-Coupled Receptor (Gpcr); Neurotensin Receptor Type 1 (Nts1); Pepducin

$105,000

Validation of cell impedance sensing as a high-throughput approach for toxicity evaluation in vitro

Principal investigatorNSERC2017Engage Grants Program

Principal investigators: Grandbois, Michel

$25,000

Mechanical characterization of cell signaling mechanisms.

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Grandbois, Michel

$205,000

Application de la résonance des plasmons de surface pour la caractérisation de processus de signalisation cellulaire

SupervisorCIHR2012Master's Award: Canada Graduate Scholarships

Principal investigators: Maltais, Jean-Sébastien

Keywords: Apoptose; Morphologie Cellulaire; Redistribution De Masse; Récepteurs Couplés Aux Protéines G; Récepteurs Tyrosine Kinase; Résonance Des Plasmons De Surface; Signalisation Intracellulaire

$17,500

Label-free Monitoring of Cellular Signals by Surface Plasmon Resonance

Principal investigatorNSERC2010Collaborative Health Research Projects

Principal investigators: Grandbois, Michel

$236,590

Structural determinants for the activation of the chemokine receptor CXCR4

Co-investigatorCIHR2009Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding)

Principal investigators: Escher, Emanuel

Keywords: Cxcl12; Cxcr4; Methionine Proximity Assay; Peptide Synthesis; Photoaffinity Labelling; Sdf1; Site-Directed Mutagenesis

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Michel Grandbois

Research

Latest papers

Latest funding

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.

Surface micropatterning for the formation of an in vitro functional endothelial model for cell-based biosensors.

Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.

Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben.

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates

Macrocyclic Inhibitors of the SARS-CoV-2 / ACE-2 Interaction in COVID-19

Peptide Diversity Generation Apparatus to Elucidate Cell-Molecules Interactions

Impact of titin post-translational modifications on muscle contractile function

Treating chronic pain with pepducins derived from neurotensin receptor type 1 (NTS1)

Validation of cell impedance sensing as a high-throughput approach for toxicity evaluation in vitro

Mechanical characterization of cell signaling mechanisms.

Application de la résonance des plasmons de surface pour la caractérisation de processus de signalisation cellulaire

Label-free Monitoring of Cellular Signals by Surface Plasmon Resonance

Structural determinants for the activation of the chemokine receptor CXCR4

Frequent collaborators

Philippe Sarret

Pierre-Luc Boudreault

Michael CANVA

Pierre Lavigne

Vincent Aimez

Louis Gendron

Jean-Bernard Denault

Richard Leduc

Robert Dumaine

Taha Azad

Mathieu Robert

Paul Charette

Graciela Pineyro

Martin Audet

Ghassan Bkaily

Michel Grandbois

Research

Latest papers

Latest funding

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new &#x3b2;-arrestin inhibitor.

Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System.

Beyond Rule-of-five: Permeability Assessment of Semipeptidic Macrocycles.

Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.

Surface micropatterning for the formation of an in vitro functional endothelial model for cell-based biosensors.

Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.

Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.

Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben.

Biomechanical Optimization of 3D Muscle Stem Cell Culture in Elastic Substrates

Macrocyclic Inhibitors of the SARS-CoV-2 / ACE-2 Interaction in COVID-19

Peptide Diversity Generation Apparatus to Elucidate Cell-Molecules Interactions

Impact of titin post-translational modifications on muscle contractile function

Treating chronic pain with pepducins derived from neurotensin receptor type 1 (NTS1)

Validation of cell impedance sensing as a high-throughput approach for toxicity evaluation in vitro

Mechanical characterization of cell signaling mechanisms.

Application de la résonance des plasmons de surface pour la caractérisation de processus de signalisation cellulaire

Label-free Monitoring of Cellular Signals by Surface Plasmon Resonance

Structural determinants for the activation of the chemokine receptor CXCR4

Frequent collaborators

Philippe Sarret

Pierre-Luc Boudreault

Michael CANVA

Pierre Lavigne

Vincent Aimez

Louis Gendron

Jean-Bernard Denault

Richard Leduc

Robert Dumaine

Taha Azad

Mathieu Robert

Paul Charette

Graciela Pineyro

Martin Audet

Ghassan Bkaily

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.