Faculty profile

Gil Privé

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ProfessorDepartment of BiochemistryUniversity of Toronto

Gil Privé

Professor

Department of Biochemistry

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
40 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.

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Academic metrics

176

Publications

11,697

Citations

Collaborators

Publications by year

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

The E3-ome gene-centric compendium reveals the human E3 ligase landscape
Cell · 2026
Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.
Bioorganic & medicinal chemistry · 2026
Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.
Bioorganic & medicinal chemistry letters · 2026

All 176 publications

From the 150 most recent of 176 publications.

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

Ngee Kiat Chua, Tania J. González-Robles, Cameron J. Reddington, Jane Dudley-Fraser, Richard W. Birkinshaw, Jiru Han, Ashleigh N. Solano, Soon Wei Wong, Tomasz Kochańczyk, Joshua J. Peter, Mark A. Nakasone, Florian Aust, Jacob E. Munro, Yeh Huei Tong, Julie Iskander, Waruni Abeysekera, Alex Garnham, Hannah Huckstep, Matthew E. Ritchie, Ingrid E. Wertz, Sarah Hymowitz, Sharad Kumar, Ron C. Conaway, Gilbert G. Privé, Alex N. Bullock, Jeffrey J. Babon, Rachel E. Klevit, Sonja Lorenz, Alessio Ciulli, Eric S. Fischer, et al. (47 authors)

Cell202618 citationsOpen Access

DOI: 10.1016/j.cell.2026.01.029 PMID: 41864206

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Watson IDG, Morin JA, Subramanian PR, Chau AM, Prakesch MA, Wilson BJ, Morshed MM, Joseph BB, Uehling DE, Poda G, Abibi A, Chan M, Cheung H, Griffin C, Mao V, Marcellus R, Strathdee C, Subramaniam R, Thériault BL, Winston J, Aman A, Kiyota T, Undzys E, Kuntz DA, Pomroy NC, Mamai A, Privé GG, Al-Awar R, Isaac MB

Bioorganic & medicinal chemistry20261 citations

DOI: 10.1016/j.bmc.2026.118575 PMID: 41621194

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Mamai A, Morshed MM, Prakesch M, Poda G, Subramanian P, Chau AM, Watson IDG, Joseph B, Wilson B, Morin JA, Marcellus R, Theriault B, Mohammed M, Abibi A, Chan M, Kiyota T, Aman A, Subramaniam R, Strathdee C, Winston J, O'Meara J, Kuntz D, Pomroy NC, Uehling D, Isaac M, Privé GG, Al-Awar R

Bioorganic & medicinal chemistry letters2026

DOI: 10.1016/j.bmcl.2025.130471 PMID: 41241078

Derivation and characterization of ubiquitin-specific protease 18 inhibitors

Blessing O. Ogunlade, Kevin N. Dalby, Samuel C. Okpechi, Eun Jeong Cho, Liliya Tyutyunyk‐Massey, Zibo Chen, Xiuxia Liu, Joseph Ivanic, Brian Luke, Shyamal D. Desai, Yair Alfaro, Ashwini K. Devkota, Rae M. Sammons, Gilbert G. Privé, Xi Liu, Ethan Dmitrovsky

JCI Insight2026Open Access

DOI: 10.1172/jci.insight.202853 PMID: 42154529

Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.

Feng Y, Goncalves MM, Jitkova Y, Keszei AFA, Yan Y, Sarathy C, St-Germain J, Kenney TMG, Tcheng M, Trudel V, Mancini RS, Upadhyay R, Hurren R, Gronda M, Schultz M, Soriano K, Lees K, Pomroy NC, Currie SQW, Privé GG, Reed MA, Yudin AK, Penn LZ, Arrowsmith CH, Raught B, Mazhab-Jafari MT, Vahidi S, Schimmer AD

Proceedings of the National Academy of Sciences of the United States of America202513 citationsOpen Access

DOI: 10.1073/pnas.2422447122 PMID: 39879245

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors

Ahmed Mamai, M. Monzur Morshed, Michael A. Prakesch, Gennady I. Poda, Subramanian Pandiaraju, Anh M. Chau, Iain D. G. Watson, Babu Joseph, Brian C. Wilson, Justin A. Morin, Richard C. Marcellus, Brigitte L. Thériault, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Taira Kiyota, Ahmed M. Aman, Ratheesh Subramaniam, Craig A. Strathdee, Jeffrey T. Winston, Jeff A. O’Meara, D.A. Kuntz, Neil C. Pomroy, David Uehling, Methvin B. Isaac, Gilbert G. Privé, Rima Al‐awar

SSRN Electronic Journal2025Open Access

DOI: 10.2139/ssrn.5691563

Abstract 5425: Human mitochondrial ClpXP protease degrades serine phosphorylated substrates

Yue Feng, Monica M. Goncalves, Yulia Jitkova, Alexander F. A. Keszei, Yongran Yan, Chaitra Sarathy, Jonathan St-Germain, Tristan M. G. Kenney, Matthew Tcheng, Vincent Trudel, Ross S. Mancini, Rahul D. Upadhyay, Rose Hurren, Marcela Gronda, Matthew Schultz, Kaylen Soriano, Kaitlin Lees, Neil C. Pomroy, Susan Currie, Gilbert G. Privé, Mark A. Reed, Andrei K. Yudin, Linda Z. Penn, C.H. Arrowsmith, Brian Raught, Mohammad T. Mazhab‐Jafari, Siavash Vahidi, Aaron David Schimmer

Cancer Research2025

DOI: 10.1158/1538-7445.am2025-5425

Discovery of Pyrrolopyrimidinone Inhibitors of the BCL6-SMRT Corepressor Interaction

Methvin Isaac, Iain D. G. Watson, Justin A. Morin, Pandiaraju R. Subramanian, Anh M. Chau, Michael A. Prakesch, Brian C. Wilson, M. Monzur Morshed, Babu Joseph, David Uehling, Gennady I. Poda, Ayome Abibi, Manuel Chan, Herman S. Cheung, Carly Griffin, Victor Y. Mao, Richard C. Marcellus, Craig A. Strathdee, Ratheesh Subramaniam, Brigitte L. Thériault, Jeffrey T. Winston, Ahmed M. Aman, Taira Kiyota, Elijus Undzys, D.A. Kuntz, Neil C. Pomroy, Ahmed Mamai, Gilbert G. Privé

SSRN Electronic Journal2025Senior authorOpen Access

DOI: 10.2139/ssrn.5933255

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Mabanglo MF, Wilson B, Noureldin M, Kimani SW, Mamai A, Krausser C, González-Álvarez H, Srivastava S, Mohammed M, Hoffer L, Chan M, Avrumutsoae J, Li ASM, Hajian T, Tucker S, Green S, Szewczyk M, Barsyte-Lovejoy D, Santhakumar V, Ackloo S, Loppnau P, Li Y, Seitova A, Kiyota T, Wang JG, Privé GG, Kuntz DA, Patel B, Rathod V, Vala A, Rout B, Aman A, Poda G, Uehling D, Ramnauth J, Halabelian L, Marcellus R, Al-Awar R, Vedadi M

Nature communications202439 citationsOpen Access

DOI: 10.1038/s41467-024-54500-x PMID: 39580491

Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Duc Minh Nguyen, Deanna H. Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X. Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, D.A. Kuntz, M. Mian, Neil C. Pomroy, Alexander F. A. Keszei, Samir Benlekbir, Mohammad T. Mazhab‐Jafari, John L. Rubinstein, Terence E. Hébert, Gilbert G. Privé

Proceedings of the National Academy of Sciences202419 citationsSenior authorOpen Access

DOI: 10.1073/pnas.2315018121 PMID: 38625940

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Gil Privé

Research

Latest papers

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

Discovery of pyrrolopyrimidinone inhibitors of the BCL6-SMRT corepressor interaction.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Derivation and characterization of ubiquitin-specific protease 18 inhibitors

Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors

Abstract 5425: Human mitochondrial ClpXP protease degrades serine phosphorylated substrates

Discovery of Pyrrolopyrimidinone Inhibitors of the BCL6-SMRT Corepressor Interaction

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Frequent collaborators

Gilbert Privé

David Scott

Christian Steidl

Housheng He

Rodger Tiedemann

Robert Kridel

Brian Raught

Régis Pomès

Ahmed Aman

Russell Bishop

David Uehling

Gennady Poda

Brian Wilson

John Klassen

Peter Hwang

Rima Al-awar

John Rubinstein

Cheryl Arrowsmith

Lewis Kay

Mohammad Mazhab-Jafari

Christopher Cairo

Razq Hakem

Levon Halabelian

Masoud Vedadi