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Masoud Vedadi

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ProfessorDepartment of Pharmacology and ToxicologyUniversity of Toronto

Masoud Vedadi

Professor

Department of Pharmacology and Toxicology

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
38 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

149

Publications

10,499

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Roles and appointments

Senior Scientific Advisor

Profiles and links

University Profile

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.
Protein science : a publication of the Protein Society · 2026 · senior author
Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.
Journal of medicinal chemistry · 2026 · senior author
S‑Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.
ACS medicinal chemistry letters · 2026

All 149 publications

Latest funding

Enabling the rapid evaluation of the WDR family of proteins as human drug targets
CFI · 2022 · Co-investigator
$778,545
Development of open-access research tools for epigenetics
CFI · 2012 · Co-investigator
$2,402,926
Structural Genomics Consortium: Structural chemistry of proteins of relevance to human health.
CFI · 2006 · Co-investigator
$3,219,885

All 3 grants and awards

149 publications.

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M

Protein science : a publication of the Protein Society2026Senior authorOpen Access

DOI: 10.1002/pro.70428 PMID: 41432309

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

Mabanglo MF, Srivastava S, Matsui Y, Li Z, Noureldin M, Pogmore JP, Hoffer L, Taherian F, Hajian T, Tucker S, Mamai A, Kiyota T, Aman A, Al-Awar R, Marcellus R, Uehling DE, Ott M, Ramnauth J, Vedadi M

Journal of medicinal chemistry2026Senior authorOpen Access

DOI: 10.1021/acs.jmedchem.6c00126 PMID: 42150007

S‑Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.

Rosas-Lemus M, Athe S, Minasov G, Pattie JA, Brunzelle JS, Chau I, Li F, Vedadi M, Ma H, Ramanathan A, Becker ME, Hope TJ, Abdelkarim H, Grudzien P, Gaponenko V, Montgomery JE, Moellering RE, Rawal VH, Satchell KJF

ACS medicinal chemistry letters2026

DOI: 10.1021/acsmedchemlett.5c00510 PMID: 41568342

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Kim A, Pan B, Yu X, Gao X, Khudaverdyan N, Taherian F, Xu C, Zhong H, Xiong Y, Kaniskan HÜ, Vedadi M, Song J, Jin J, Cai L, Wang GG

Nature cell biology2026

DOI: 10.1038/s41556-026-02048-x PMID: 42601451

Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-l-methionine.

Zhou J, Deng Y, Yu D, Hajian T, Vedadi M, Zhang X, Blumenthal RM, Huang R, Cheng X

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.08.13.670177 PMID: 41669157

Inhibition of Clostridioides difficile-Specific DNA Adenine Methyltransferase CamA by Analogs of S‑Adenosyl‑l‑methionine.

Zhou J, Deng Y, Yu D, Hajian T, Vedadi M, Zhang X, Blumenthal RM, Huang R, Cheng X

ACS omega2025

DOI: 10.1021/acsomega.5c09571 PMID: 41358085

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Mabanglo MF, Wilson B, Noureldin M, Kimani SW, Mamai A, Krausser C, González-Álvarez H, Srivastava S, Mohammed M, Hoffer L, Chan M, Avrumutsoae J, Li ASM, Hajian T, Tucker S, Green S, Szewczyk M, Barsyte-Lovejoy D, Santhakumar V, Ackloo S, Loppnau P, Li Y, Seitova A, Kiyota T, Wang JG, Privé GG, Kuntz DA, Patel B, Rathod V, Vala A, Rout B, Aman A, Poda G, Uehling D, Ramnauth J, Halabelian L, Marcellus R, Al-Awar R, Vedadi M

Nature communications202439 citationsSenior authorOpen Access

DOI: 10.1038/s41467-024-54500-x PMID: 39580491

A chemical probe to modulate human GID4 Pro/N-degron interactions.

Owens DDG, Maitland MER, Khalili Yazdi A, Song X, Reber V, Schwalm MP, Machado RAC, Bauer N, Wang X, Szewczyk MM, Dong C, Dong A, Loppnau P, Calabrese MF, Dowling MS, Lee J, Montgomery JI, O'Connell TN, Subramanyam C, Wang F, Adamson EC, Schapira M, Gstaiger M, Knapp S, Vedadi M, Min J, Lajoie GA, Barsyte-Lovejoy D, Owen DR, Schild-Poulter C, Arrowsmith CH

Nature chemical biology202429 citations

DOI: 10.1038/s41589-024-01618-0 PMID: 38773330

Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.

Yazdi AK, Perveen S, Dong C, Song X, Dong A, Szewczyk MM, Calabrese MF, Casimiro-Garcia A, Chakrapani S, Dowling MS, Ficici E, Lee J, Montgomery JI, O'Connell TN, Skrzypek GJ, Tran TP, Troutman MD, Wang F, Young JA, Min J, Barsyte-Lovejoy D, Brown PJ, Santhakumar V, Arrowsmith CH, Vedadi M, Owen DR

RSC medicinal chemistry202415 citationsOpen Access

DOI: 10.1039/d3md00633f PMID: 38516600

Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor

Yan Xiong, Holger Greschik, C. Johansson, Ludwig Seifert, Vicki Gamble, Kwang‐Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, C.H. Arrowsmith, Paul E. Brennan, O. Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo C. T. Oppermann, Roland Schüle, Jian Jun Jin

Journal of Medicinal Chemistry20244 citationsOpen Access

DOI: 10.1021/acs.jmedchem.4c00121 PMID: 38533580

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Masoud Vedadi

Research

Latest papers

Latest funding

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

S‑Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-l-methionine.

Inhibition of Clostridioides difficile-Specific DNA Adenine Methyltransferase CamA by Analogs of S‑Adenosyl‑l‑methionine.

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

A chemical probe to modulate human GID4 Pro/N-degron interactions.

Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.

Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor

Enabling the rapid evaluation of the WDR family of proteins as human drug targets

Development of open-access research tools for epigenetics

Structural Genomics Consortium: Structural chemistry of proteins of relevance to human health.

Frequent collaborators

Cheryl Arrowsmith

Matthieu Schapira

Dalia Barsyte-Lovejoy

Jinrong Min

Rima Al-awar

Levon Halabelian

Ahmed Aman

Aled Edwards

Yuri Bolshan

Gennady Poda

Borhane Annabi

David Uehling

Alexandre Gagnon

Rachel Harding

Anne-Claude Gingras

Colby Zaph

Stéphane Richard

Jack Greenblatt

Jason Moffat

Steven Laplante

Sachdev Sidhu

Masoud Vedadi

Research

Latest papers

Latest funding

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities.

Self-Dimerization Induced Proximity Targeting Chimeras (SDIPTAC) Lead to DCAF1 Loss of Function and Inhibition of HIV Replication.

S&#x2011;Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.

An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis.

Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-l-methionine.

Inhibition of Clostridioides difficile-Specific DNA Adenine Methyltransferase CamA by Analogs of S&#x2011;Adenosyl&#x2011;l&#x2011;methionine.

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

A chemical probe to modulate human GID4 Pro/N-degron interactions.

Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.

Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor

Enabling the rapid evaluation of the WDR family of proteins as human drug targets

Development of open-access research tools for epigenetics

Structural Genomics Consortium: Structural chemistry of proteins of relevance to human health.

Frequent collaborators

Cheryl Arrowsmith

Matthieu Schapira

Dalia Barsyte-Lovejoy

Jinrong Min

Rima Al-awar

Levon Halabelian

Ahmed Aman

Aled Edwards

Yuri Bolshan

Gennady Poda

Borhane Annabi

David Uehling

Alexandre Gagnon

Rachel Harding

Anne-Claude Gingras

Colby Zaph

Stéphane Richard

Jack Greenblatt

Jason Moffat

Steven Laplante

Sachdev Sidhu

S‑Adenosylhomocysteine Analogs Selectively Suppress Pan-Coronavirus Replication by Inhibition of nsp14 Methyltransferase.

Inhibition of Clostridioides difficile-Specific DNA Adenine Methyltransferase CamA by Analogs of S‑Adenosyl‑l‑methionine.