Faculty profile

Benoit Coulombe

Back to faculty

ProfessorDépartement de biochimie et médecine moléculaireUniversité de Montréal

Benoit Coulombe

Professor

Département de biochimie et médecine moléculaire

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
8 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 2 research grants (1 CFI, 1 NSERC), most recently in 2009.
Supervisor on 1 trainee award (1 CIHR), most recently in 2008.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,085

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

University Profile Google Scholar

Search on ResearchGate

iDORCID OpenAlex

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their Université de Montréal profile.

COVID-19 COVID19

Latest papers

Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease.
The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
AI-Powered Identification of Human Cell Surface Protein Interactors of the Hemagglutinin Glycoprotein of High-Pandemic-Risk H5N1 Influenza Virus.
Viruses · 2025 · senior author
ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
Genome biology · 2024

All 21 publications

Latest funding

Neuroligin-1 and neuroligin-2 as blood biomarkers of prodromal Alzheimer's disease
CIHR · 2025 · Co-investigator
$879,750
Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies
CIHR · 2019 · Co-investigator
$1,113,075
Reducing the activity of the phosphatase STEP to improve memory performance during aging
CIHR · 2019 · Co-investigator
$100,000

All 12 grants and awards

21 publications.

Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease.

Fernandes MGF, Pinard M, Sokullu E, Tremblay C, Gagnon JF, Calon F, Coulombe B, Brouillette J

The journals of gerontology. Series A, Biological sciences and medical sciences20261 citationsOpen Access

DOI: 10.1093/gerona/glag009 PMID: 41639022

AI-Powered Identification of Human Cell Surface Protein Interactors of the Hemagglutinin Glycoprotein of High-Pandemic-Risk H5N1 Influenza Virus.

Poitras C, Coulombe B

Viruses2025Senior author

DOI: 10.3390/v17121638 PMID: 41472307

ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.

Luo H, Lao L, Au KS, Northrup H, He X, Forget D, Gauthier MS, Coulombe B, Bourdeau I, Shi W, Gagliardi L, Fragoso MCBV, Peng J, Wu J

Genome biology202418 citationsOpen Access

DOI: 10.1186/s13059-023-03147-w PMID: 38225631

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

Chofflet N, Naito Y, Pastore AJ, Padmanabhan N, Nguyen PT, Poitras C, Feller B, Yi N, Van Prooijen J, Khaled H, Coulombe B, Clapcote SJ, Bourgault S, Siddiqui TJ, Rudenko G, Takahashi H

Frontiers in molecular neuroscience20248 citationsOpen Access

DOI: 10.3389/fnmol.2024.1371145 PMID: 38571813

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

Benoit Coulombe, Thomas M. Durcan, Geneviève Bernard, Asmae Moursli, Christian Poitras, Denis Faubert, Maxime Pinard

Molecular Brain20242 citationsFirst authorOpen Access

DOI: 10.1186/s13041-024-01088-4 PMID: 38605409

Biallelic pathogenic variants in POLR3D alter tRNA transcription and cause a hypomyelinating leukodystrophy: A case report

Julia Macintosh, Stefanie Perrier, Maxime Pinard, Luan T. Tran, Kether Guerrero, Chitra Prasad, Asuri Narayan Prasad, Tomi Pastinen, Isabelle Thiffault, Benoit Coulombe, Geneviève Bernard

Frontiers in Neurology202313 citationsOpen Access

DOI: 10.3389/fneur.2023.1254140 PMID: 37915380

Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy

Mackenzie A. Michell‐Robinson, Kristin E. Noack Watt, Vladimir Grouza, Julia Macintosh, Maxime Pinard, Marius Tuznik, Xiaoru Chen, Lama Darbelli, Chia‐Lun Wu, Stefanie Perrier, Daryan Chitsaz, Nonthué A. Uccelli, Hanwen Liu, Timothy C. Cox, Christoph W. Müller, Timothy E. Kennedy, Benoit Coulombe, David A. Rudko, Paul A. Trainor, Geneviève Bernard

Brain202312 citationsOpen Access

DOI: 10.1093/brain/awad249 PMID: 37635302

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Linjiang Lao, Isabelle Bourdeau, Lucia Gagliardi, Xiao He, Wei Shi, Bingbing Hao, Minjia Tan, Yan Helen Hu, Junzheng Peng, Benoit Coulombe, David James Torpy, Hamish S. Scott, André Lacroix, Hongyu Luo, Jiangping Wu

Nucleic Acids Research202250 citationsOpen Access

DOI: 10.1093/nar/gkac483 PMID: 35687106

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.

Gaspar VP, Ramos AC, Cloutier P, Pattaro Junior JR, Duarte Junior FF, Bouchard A, Seixas FAV, Coulombe B, Fernandez MA

Current issues in molecular biology2021

DOI: 10.3390/cimb43020056 PMID: 34449532

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).

Ben Djoudi Ouadda A, Gauthier MS, Susan-Resiga D, Girard E, Essalmani R, Black M, Marcinkiewicz J, Forget D, Hamelin J, Evagelidis A, Ly K, Day R, Galarneau L, Corbin F, Coulombe B, Çaku A, Tagliabracci VS, Seidah NG

Arteriosclerosis, thrombosis, and vascular biology201956 citationsOpen Access

DOI: 10.1161/atvbaha.119.313247 PMID: 31553664

Neuroligin-1 and neuroligin-2 as blood biomarkers of prodromal Alzheimer's disease

Co-investigatorCIHR2025Project Grant

Principal investigators: Brouillette, Jonathan

Keywords: Alzheimer'S Disease; Blood Biomarker; Mass Spectrometry; Mild Cognitive Impairment (Mci); Neuroligins

$879,750

Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies

Co-investigatorCIHR2019Project Grant

Principal investigators: Bernard, Geneviève

Keywords: Eprs1-Related Leukodystrophy; Gene Discovery; Hypomyelinating Leukodystrophies; Induced Pluripotent Stem Cells; Myelination Studies; Next Generation Sequencing; Oligodendrocyte Progenitor Cells / Oligodendrocytes; Polr3-Related Leukodystrophy; Proteomics; Rare Diseases

$1,113,075

Reducing the activity of the phosphatase STEP to improve memory performance during aging

Co-investigatorCIHR2019Project Grant - PA: Neurosciences, Mental Health and Addiction

Principal investigators: Brouillette, Jonathan

Keywords: Animal Model; Hippocampus; Memory Deficits; Molecular Biology; Phosphatase Step

$100,000

A patient-derived iPSC platform of disease relevant cell models for biological studies

Co-investigatorBRAIN2017ALS Arthur J. Hudson Translational Team Grant

Principal investigators: Rouleau, Guy; Puymirat, Jack

Keywords: Neurodegeneration; ALS

$2,203,120

Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies

Co-investigatorCIHR2016Project Grant

Principal investigators: Bernard, Geneviève

Keywords: 4h Leukodystrophy; Genomics; Hypomyelinating Leukodystrophies; Leukodystrophies; Pathophysiology; Proteomics; Trna Synthetases

$563,959

POLR3-related leukodystrophy: From bench to bedside

Co-investigatorCIHR2015Operating Grant

Principal investigators: Bernard, Geneviève

Keywords: 4h Leukodystrophy; Hypomyelination; Magnetic Resonance Imaging; Mouse Model; Natural History Study; Next Generation Sequencing; Pathophysiological Mechanisms; Polr3-Related Leukodystrophy; Polymerase Iii; Rna Sequenging

$100,000

Clinical, molecular and pathophysiological characterization of Pol III-related leukodystrophies

Co-investigatorCIHR2012Operating Grant

Principal investigators: Bernard, Geneviève

Keywords: Clinical Characterization; Exome Sequencing; Hypomyelination; Magnetic Resonance Imaging; Mouse Model; Pathophysiological Mechanisms; Pol Iii-Related Leukodystrophies; Polymerase Iii; Rna Expression Array

$453,883

THE MONTREAL CARDIOMETABOLIC BIOMARKER AND DRUG DISCOVERY CONSORTIUM (BIOcMET)

Co-investigatorCFI2012Innovation Fund: Leading Edge Fund (2012 competition)

Principal investigators: Prentki, Marc

Keywords: Diabetes, obesity, metabolic syndrome, dyslipidemia, metabolomics, interactomics, bioinformatics, biomarkers, drug discovery LCMSMS, HPLC, PCR, rodent and human phenotyping, servers

$2,312,056

NSERC CREATE Training Program in Cellular dynamics of macromolelecular complexes

Co-investigatorNSERC2010Collaborative Research and Training Experience

Principal investigators: Baron, Christian

$1,600,000

A Multi-Site, Integrated National Technology Platform for Mapping Protein Interaction Networks in Health and Disease

Principal investigatorCFI2009Innovation Fund: Leading Edge Fund 2009

Principal investigators: COULOMBE, Benoit

Keywords: systems biology, proteomics, protein interaction networks, mass spectrometers, cell biology, functional genomics, bioinformatics

$9,161,648

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

Something wrong or missing on this profile? Suggest a correction

Benoit Coulombe

Research

Latest papers

Latest funding

Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease.

AI-Powered Identification of Human Cell Surface Protein Interactors of the Hemagglutinin Glycoprotein of High-Pandemic-Risk H5N1 Influenza Virus.

ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.

Structural and functional characterization of the IgSF21-neurexin2&#x3b1; complex and its related signaling pathways in the regulation of inhibitory synapse organization.

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

Biallelic pathogenic variants in POLR3D alter tRNA transcription and cause a hypomyelinating leukodystrophy: A case report

Hypomyelination, hypodontia and craniofacial abnormalities in a Polr3b mouse model of leukodystrophy

ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia

Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein.

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).

Neuroligin-1 and neuroligin-2 as blood biomarkers of prodromal Alzheimer's disease

Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies

Reducing the activity of the phosphatase STEP to improve memory performance during aging

A patient-derived iPSC platform of disease relevant cell models for biological studies

Unraveling the molecular basis of novel forms of hypomyelinating leukodystrophies

POLR3-related leukodystrophy: From bench to bedside

Clinical, molecular and pathophysiological characterization of Pol III-related leukodystrophies

THE MONTREAL CARDIOMETABOLIC BIOMARKER AND DRUG DISCOVERY CONSORTIUM (BIOcMET)

NSERC CREATE Training Program in Cellular dynamics of macromolelecular complexes

A Multi-Site, Integrated National Technology Platform for Mapping Protein Interaction Networks in Health and Disease

Frequent collaborators

Geneviève Bernard

Mathieu Blanchette

Mathieu Lavallée-Adam

Vincent Ferretti

Guy Poirier

Jiangping Wu

Hongyu Luo

Frédéric Calon

Timothy Kennedy

Jacques Archambault

Tomi Pastinen

Rémi Rabasa-Lhoret

Hideto Takahashi

Steve Bourgault

Benoît Chabot

Tabrez Siddiqui

Bernard Brais

Amélie Fradet-Turcotte

Jacques Archambault

Robert Day

Thomas Durcan

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.