Faculty profile
Mike Tyers
Back to facultyResearch
Read how they describe their research on their University of Toronto profile.
Latest papers
A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation
Disease Models & Mechanisms · 2026 · senior author
CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.
Environmental research · 2026
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026 · senior author
26 publications.
A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation
Palou R, van der Sloot AM, Fiebig AA, Zangara MT, Sangwan N, Sánchez-Osuna M, Ilyas B, Zubyk H, Cook M, Wright GD
CRISPR screen uncovers SLC26A2 as a modulator of tungsten toxicity in endochondral ossification.
Bakadlag R, Li S, Guilbert C, Huard C, Bertomeu T, Coulombe-Huntington J, Jackson BP, Grant MP, Iskandarani L, Paganini C, Rossi A, Mwale F, Tyers M, Hales BF, Mann KK
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.
Papadopoli D, Palia R, Jovanovic P, Tabariès S, Ciccolini E, Sabourin V, Igelmann S, McLaughlan S, Zhan L, Kim H, Chekkal N, Szkop KJ, Bertomeu T, Zeng J, Vassalakis J, Afzali F, Mzoughi S, Guccione E, Tyers M, Avizonis D, Larsson O, Postovit LM, Djuranovic S, Ursini-Siegel J, Siegel PM, Pollak M, Topisirovic I
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Mader P, Liu L, Vallée F, Denis F, Pau V, Mao D, Caldwell L, Chan K, Kurinov I, Mamane Y, Parikh P, Zhang Z, Gallant M, Tyers M, Black WC, Zinda M, Durocher D, Wrana J, Zimmermann M, Sicheri F
The scaffold protein PRR14L is linked to mitotic fidelity and sensitivity to MPS1 inhibition.
Liu AZ, Narkar A, Li K, Bertomeu T, Johnson BA, Coulombe-Huntington J, Dong Y, Zhu J, Tyers M, Li R
De novo design of potent inhibitors of clostridial family toxins.
Ragotte RJ, Liang H, Tam J, Miletic S, Berman JM, Palou R, Weidle C, Li Z, Glögl M, Beilhartz GL, Carr KD, Borst AJ, Coventry B, Wang X, Rubinstein JL, Tyers M, Schramek D, Melnyk RA, Baker D
Engineered spermidine-secreting Saccharomyces boulardii ameliorates colitis and colon cancer in mice
Mohaqiq M, Palou R, Li R, Zhang G, Vaishnav H, Parweez F, Moyana T, Carragher D, Cameron DW, Ramsay T
Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster.
Parweez F, Palou R, Li R, Kadhim L, MacMillan H, Tyers M, Liu XJ
The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.
Liu AZ, Narkar A, Li K, Bertomeu T, Johnson BA, Coulombe-Huntington J, Dong Y, Zhu J, Tyers M, Li R
Frequent collaborators
- Peter Dirks and Daniel Schramek: 263 shared papers
- Brenda Andrews and Charles Boone: 163 shared papers
- Corey Nislow and Guri Giaever: 163 shared papers
- Frank Sicheri and Daniel Durocher: 30 shared papers
- Peter Dirks and Gary Bader: 29 shared papers
- Charles Boone and Gary Bader: 25 shared papers
- Charles Boone and Corey Nislow: 22 shared papers
- Charles Boone and Guri Giaever: 18 shared papers
- Gary Bader and Daniel Schramek: 18 shared papers
- Brenda Andrews and Corey Nislow: 17 shared papers
- Brenda Andrews and Gary Bader: 14 shared papers
- Brian Coombes and Gerard Wright: 13 shared papers
- Brenda Andrews and Guri Giaever: 12 shared papers
- Brian Raught and Gary Bader: 9 shared papers
- Brenda Andrews and Brian Raught: 6 shared papers
- Charles Boone and Brian Raught: 6 shared papers
- Frank Sicheri and Daniela Rotin: 5 shared papers
- Frank Sicheri and Brian Raught: 5 shared papers
- Frank Sicheri and Anne Marinier: 5 shared papers
- Frank Sicheri and Mike Tyers: 5 shared papers
- Daniela Rotin and Brian Raught: 5 shared papers
- Gerard Wright and Charles Boone: 4 shared papers
- Charles Boone and Daniel Durocher: 4 shared papers
- Peter Dirks and Phedias Diamandis: 4 shared papers
- Frank Sicheri and Daniel Schramek: 3 shared papers
- Brenda Andrews and Daniel Durocher: 3 shared papers
- Daniel Durocher and Mike Tyers: 3 shared papers
- Peter Dirks and Adrian Sacher: 3 shared papers
- Peter Dirks and Mike Tyers: 3 shared papers
- Anne Marinier and Brian Wilhelm: 3 shared papers
- Phedias Diamandis and Adrian Sacher: 3 shared papers
- Brian Coombes and Mike Tyers: 2 shared papers
- Frank Sicheri and John Rohde: 2 shared papers
- Daniel Durocher and Daniela Rotin: 2 shared papers
- Brian Raught and Mike Tyers: 2 shared papers
- Corey Nislow and Mike Tyers: 2 shared papers
- Ivan Topisirovic and Brian Wilhelm: 2 shared papers
- Ivan Topisirovic and Mike Tyers: 2 shared papers
- Phedias Diamandis and Mike Tyers: 2 shared papers
- Adrian Sacher and Mike Tyers: 2 shared papers
- Xingquan Liu and Mike Tyers: 2 shared papers
- Guri Giaever and Mike Tyers: 2 shared papers
- John Rohde and Mike Tyers: 2 shared papers
- Brian Coombes and Xingquan Liu: 1 shared paper
- Gerard Wright and Frank Sicheri: 1 shared paper
- Gerard Wright and Mike Tyers: 1 shared paper
- Frank Sicheri and Alain Verreault: 1 shared paper
- Frank Sicheri and Ivan Topisirovic: 1 shared paper
- Frank Sicheri and Damien D'Amours: 1 shared paper
- Frank Sicheri and Brian Wilhelm: 1 shared paper
- Brenda Andrews and Mike Tyers: 1 shared paper
- Charles Boone and Mike Tyers: 1 shared paper
- Alain Verreault and Brian Raught: 1 shared paper
- Alain Verreault and Peter Dirks: 1 shared paper
- Alain Verreault and Anne Marinier: 1 shared paper
- Alain Verreault and Damien D'Amours: 1 shared paper
- Alain Verreault and Mike Tyers: 1 shared paper
- Daniela Rotin and Mike Tyers: 1 shared paper
- Brian Raught and Damien D'Amours: 1 shared paper
- Gary Bader and Mike Tyers: 1 shared paper
- Corey Nislow and John Rohde: 1 shared paper
- Daniel Schramek and Mike Tyers: 1 shared paper
- Barbara Hales and Fackson Mwale: 1 shared paper
- Barbara Hales and Mike Tyers: 1 shared paper
- Fackson Mwale and Mike Tyers: 1 shared paper
- Anne Marinier and Mike Tyers: 1 shared paper
- Damien D'Amours and Mike Tyers: 1 shared paper
- Brian Wilhelm and Mike Tyers: 1 shared paper
- Department of Molecular Genetics
- Department of Biochemistry and Biomedical Sciences
- Department of Biochemistry
- Department of Surgery
- Department of Medicine
- Department of Medical Biophysics
- Department of Microbiology & Immunology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Frank Sicheri
Department of Molecular Genetics
5 shared papers, latest 2026
Daniel Durocher
Department of Molecular Genetics
3 shared papers, latest 2026
Peter Dirks
Department of Surgery
3 shared papers, latest 2026
Adrian Sacher
Department of Medicine
2 shared papers, latest 2009
Brian Coombes
Department of Biochemistry and Biomedical Sciences
2 shared papers, latest 2026
Xingquan Liu
Obstetrics and Gynecology
2 shared papers, latest 2025
Guri Giaever
Faculty
2 shared papers, latest 2010
Brian Raught
Department of Medical Biophysics
2 shared papers, latest 2026
Corey Nislow
Faculty
2 shared papers, latest 2010
John Rohde
Department of Microbiology & Immunology
2 shared papers, latest 2012
Ivan Topisirovic
Department of Biochemistry
2 shared papers, latest 2026
Phedias Diamandis
Department of Laboratory Medicine & Pathobiology
2 shared papers, latest 2009
Masoud Vedadi
Department of Pharmacology and Toxicology
1 shared papers, latest 2013
Daniela Rotin
Department of Biochemistry
1 shared papers, latest 2013
Peter Roy
Department of Molecular Genetics
1 shared papers, latest 2010
John Rubinstein
Department of Biochemistry
1 shared papers, latest 2025
Peter Siegel
Goodman Cancer Institute
1 shared papers, latest 2026
Sachdev Sidhu
Donnelly Centre
1 shared papers, latest 2013
Guy Sauvageau
Département de pharmacologie et physiologie
1 shared papers, latest 2026
Jeffrey Wrana
Department of Molecular Genetics
1 shared papers, latest 2026
Gary Bader
Terrence Donnelly Centre for Cellular and Biomolecular Research
1 shared papers, latest 2010
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.
Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.